Abstract:
:Potentiality of a protective effect of methionine against hepatotoxic action of vinyl chloride (VC) was assessed on rats, induced with phenobarbital and thereafter exposed to 50 000 ppm VC for 5 h. This extremely high dosage of VC warranted the appearance of drastic symptoms of liver injury in the course of 20 h postexposure. DL-Methionine in a dose of 1 g/kg given by gavage prior to the VC-exposure counteracted both the BC-provoked depletion of non-protein sulphydryls and destruction of cytochrome P-450 in the liver. In the methionine-pretreated rats the phenobarbital-induced synthesis of microsomal proteins in the livers was maintained during the post-exposure period, contrary to the non-pretreated animals. It may be justified to apply methionine as a prophylactic agent in cases of occupational exposure to VC.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Wisniewska-Knypl JM,Sokal JA,Klimczak J,Dajniak A,Bogdanikowa Bdoi
10.1016/0378-4274(81)90043-6subject
Has Abstractpub_date
1981-05-01 00:00:00pages
147-52issue
3eissn
0378-4274issn
1879-3169pii
0378-4274(81)90043-6journal_volume
8pub_type
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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