Abstract：
:After toxicological studies with nitrate/nitrite in rats it was observed with nuclear magnetic resonance that N-methylnicotinamide (NMN), a metabolite of tryptophan was increased. The use of NMN as a biomarker for nitrate/nitrite exposure was investigated further in additional experiments with rats and in a human study with volunteers. Rats have been exposed to 36 mmol KCl, KNO2 or KNO3 per 1 tap water for 13 weeks. In general, the animals receiving KNO2 showed a statistically significant (P < 0.01) 2-fold increase in NMN compared with the KCl group. This increase was observed after a relatively high exposure (about 800 mg/kg body wt./day). It was also noticed that the initial increase in urinary NMN concentrations decreased after prolonged exposure for 12 weeks. To investigate the induction of urinary NMN in humans, an experiment has been performed in which 8 volunteers received a single oral dose of sodium nitrate, corresponding with 10 mg NaNO3/kg body wt./day (2 times the acceptable daily intake for nitrate). A rapid increase of urinary NMN (up to 6-fold) was observed in 4 volunteers. In the other 4 volunteers the urinary NMN concentration did hardly react. When the experiment was repeated with the same volunteers, it was remarkable to see that in this experiment all volunteers showed the same individual response on urinary NMN as in the first experiment. It is concluded that NMN can possibly be a good biomarker for the internal nitrite exposure of humans, but further studies are necessary to assess its value.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Jansen EH,van den Berg RH,Boink AB,Hegger C,Meulenbelt Jdoi
10.1016/0378-4274(95)03306-8subject
Has Abstractpub_date
1995-05-01 00:00:00pages
265-9issue
1-3eissn
0378-4274issn
1879-3169pii
0378-4274(95)03306-8journal_volume
77pub_type
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journal_title：Toxicology letters
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更新日期：1982-12-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1982-11-01 00:00:00
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journal_title：Toxicology letters
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doi：10.1016/0378-4274(95)03624-5
更新日期：1995-12-01 00:00:00
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journal_title：Toxicology letters
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pub_type： 杂志文章,评审
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更新日期：1998-12-28 00:00:00
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journal_title：Toxicology letters
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pub_type： 杂志文章
doi：10.1016/0378-4274(91)90117-o
更新日期：1991-06-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.05.643
更新日期：2013-07-31 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.toxlet.2017.12.023
更新日期：2018-03-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.toxlet.2003.12.012
更新日期：2004-03-14 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.11.009
更新日期：2017-01-04 00:00:00
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pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章,多中心研究
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更新日期：2019-10-10 00:00:00
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journal_title：Toxicology letters
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pub_type： 杂志文章
doi：10.1016/j.toxlet.2019.03.012
更新日期：2019-09-15 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1992-11-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.01.034
更新日期：2014-04-07 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2019.02.002
更新日期：2019-05-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.11.031
更新日期：2015-01-22 00:00:00
abstract：:Benzene is an occupational and environmental toxicant. The major health concern for humans is acute myelogenous leukemia. To exert its toxic effects, benzene must be metabolized by cytochrome P450 to phenol and subsequently to catechol and hydroquinone. Previous research has implicated CYP2E1 in the metabolism of phen...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(01)00441-6
更新日期：2001-12-15 00:00:00
abstract：:A comparison of the effects produced by size-fractionated tire particles (TP10 and TP2.5) and similar-sized urban particulate matter (PM10 and PM2.5), collected in Milan in 2007, on the lungs of mice has been performed. The focus is on early acute lung responses following intratracheal instillation of aerosolized part...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2010.07.002
更新日期：2010-10-05 00:00:00
abstract：:It has reported that many environmental compounds may display estrogenic actions and these findings led to researchers to associate breast cancer risk with the use of some pesticides. The aim of this work was to investigate the effect of chlorpyrifos (CPF) on cell proliferation and the ERα-dependence of this action em...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2012.06.017
更新日期：2012-09-03 00:00:00
