Recent developments in analytical toxicology: for better or for worse.

abstract：:The purpose of the study was to investigate the neurotoxic effect of multi-walled carbon nanotubes (MWCNTs) on the properties of glutamatergic synaptic transmission in rat's hippocampal slices using whole-cell patch clamp technique. The amplitude and frequency of excitatory postsynaptic current (EPSC) were accessed on...

journal_title：Toxicology letters

authors： Chen T,Yang J,Zhang H,Ren G,Yang Z,Zhang T

更新日期：2014-09-17 00:00:00

abstract：:Mitochondrial enzymes are targets of newly synthesized drugs being tested for the treatment of neurodegenerative disorders, such as Alzheimer's disease (AD). The enzyme 17β-hydroxysteroid dehydrogenase type 10 (HSD10) is a multifunctional mitochondrial protein that is thought to play a role in the pathophysiology of A...

journal_title：Toxicology letters

authors： Fišar Z,Musílek K,Benek O,Hroch L,Vinklářová L,Schmidt M,Hroudová J,Raboch J

更新日期：2021-03-15 00:00:00

abstract：:EDTA, 1,2-cyclohexylenediamine tetra-acetic acid (CDTA), hexamethylene 1,6-diamine N,N,N',N'-tetra-acetic acid (HDTA), diethylene-triamine pentaacetic acid (DTPA) and nitrilotriacetic acid (NTA) were examined for the removal of manganese-54(54Mn) from some organs of sham-operated and partially hepatectomized rats in e...

journal_title：Toxicology letters

authors： Kaur G,Srivastava UC,Dwivedi RS,Srivastava RC

更新日期：1984-07-01 00:00:00

abstract：:Apoptosis has been described as programmed active cell death. Overexpression of the c-Myc gene has been shown to induce apoptosis in Rat1A/Myc-ER cells when combined with a growth blocking agent. In the present study, we tested whether 4-Hydroxynonenal (HNE) or N-acetyl-L-cysteine (LNAC) affect apoptotic death in seru...

journal_title：Toxicology letters

authors： Yildiz D,Erçal N,Frank RL,Matthews RH

更新日期：1996-12-31 00:00:00

abstract：:Rats (Fisher, Wistar, Donryu and Sprague-Dawley strains) were exposed to 5 approximately 3500 ppm toluene for 8 h, and urine samples were analyzed for hippuric acid and cresols. While hippuric acid increased in proportion to the exposure concentration, a sharp increase in o-cresol excretion was observed at high toluen...

journal_title：Toxicology letters

authors： Inoue O,Seiji K,Ishihara N,Kumai M,Ikeda M

更新日期：1984-11-01 00:00:00

abstract：:Effect of chrysotile dust alone or together with Candida albicans administered intratracheally in guinea pigs was studied in the genesis of pleural plaques over a period of 12 months. A significant increase of mucopolysaccharides, phosphorus, calcium and -SH content was detected in pleural fluid of animals treated wit...

journal_title：Toxicology letters

authors： Saxena KC,Srivastava L,Ali S,Dogra RK

更新日期：1982-10-01 00:00:00

abstract：:Stable and specific biomacromolecular adducts can be used to measure in vivo doses of reactive compounds. An LC/MS-MS method to measure adducts from the benzo[a]pyrene (BP) metabolite (±)-anti-BP-7,8-diol-9,10-epoxide ((±)-anti-BPDE) to His(146) in serum albumin (SA), earlier evaluated on in vitro alkylated human SA, ...

journal_title：Toxicology letters

authors： Westberg EA,Singh R,Hedebrant U,Koukouves G,Souliotis VL,Farmer PB,Segerbäck D,Kyrtopoulos S,Törnqvist MÅ

更新日期：2015-01-05 00:00:00

abstract：:Physiologically based kinetic (PBK) models for farm animals are of growing interest in food and feed safety with key applications for regulated compounds including quantification of tissue concentrations, kinetic parameters and the setting of safe exposure levels on an internal dose basis. The development and applicat...

journal_title：Toxicology letters

authors： Lautz LS,Dorne JLCM,Oldenkamp R,Hendriks AJ,Ragas AMJ

更新日期：2020-02-01 00:00:00

abstract：:The industrial solvent dioxane (1,4-diethylene dioxide) was evaluated for teratogenic potential in Sprague-Dawley rats. The compound was administered on days 6-15 of gestation by gavage (0, 0.25, 0.5 and 1.0 ml/kg/day). A slight maternal toxicity, as evidenced by reduced weight gain, was observed with 1.0 ml/kg. Anima...

journal_title：Toxicology letters

authors： Giavini E,Vismara C,Broccia ML

更新日期：1985-07-01 00:00:00

abstract：:Between 1997 and 2011, more than 200 new substances were notified through the early-warning system, with the record number of 49 novel molecules reported in 2011. The pattern of acute toxicity associated with the consumption of these new substances is generally similar to that seen with traditional drugs of abuse. Rec...

journal_title：Toxicology letters

authors： Coppola M,Mondola R

更新日期：2012-07-07 00:00:00

abstract：:Cadmium is a carcinogenic metal known to increase the expression of several protooncogenes in a variety of cells. although the underlying mechanisms are unknown. Renal mesangial cells are smooth muscle cells in which Ca2+ signaling pathways regulate the induction of c-fos through both cAMP-dependent and mitogen-activa...

journal_title：Toxicology letters

authors： Templeton DM,Wang Z,Miralem T

更新日期：1998-03-16 00:00:00

abstract：:Cytotoxicity in terms of haemolytic potency in vitro of eight surfactants failed to correlate with in vivo rabbit eye irritancy. Ability of the same surfactants to block spontaneous contractions of mouse and rabbit isolated ileum (especially the latter), correlated better with in vivo findings in rabbit eyes. Effectiv...

journal_title：Toxicology letters

authors： Muir CK,Flower C,Van Abbé NJ

更新日期：1983-08-01 00:00:00

abstract：:Samples of PM(2.5) were gravimetrically collected during the winter 2005/2006 in the urban area of Milan (North Italy). Samples were chemically characterized and the particles were detached from filters to determine their cytotoxic effects on the A549 cell line. Based on the potential toxicological relevance of its co...

journal_title：Toxicology letters

authors： Gualtieri M,Mantecca P,Corvaja V,Longhin E,Perrone MG,Bolzacchini E,Camatini M

更新日期：2009-07-10 00:00:00

abstract：:Oral administration of a single dose of dibutyltin dilaurate (DBTL, 80 mg/kg body wt.), 2 or 24 h after treatment, caused no significant change in the levels of diacylglycerol and phosphoinositides in rat cerebrum (forebrain), whereas daily administration of DBTL (40 or 80 mg/kg body wt.) for 3 days (24 h after the fi...

journal_title：Toxicology letters

authors： Subramoniam A,Husain R,Seth PK

更新日期：1991-08-01 00:00:00

abstract：:On chronic administration of 20 microliter of chilli extract to the cheek pouch of hamsters till death, 23% of the hamsters developed shrunken eye balls and closing of the eyelids. This effect was not observed in hamsters which received a single application of the potent carcinogen methylacetoxymethyl nitrosamine (DMN...

journal_title：Toxicology letters

authors： Agrawal RC,Sarode AV,Lalitha VS,Bhide SV

更新日期：1985-10-01 00:00:00

abstract：:In order to study the effect of arsenic on DNA damage, Sprague-Dawley rats were dosed with sodium arsenite (10 mg/kg) with or without 800 microg of benzo(a)pyrene (BP) by intramammilary injection. The animals were sacrificed on day 1, 3, 5, 10 and 27 and the mammary gland tissues were collected for DNA adduct measurem...

journal_title：Toxicology letters

authors： Tran HP,Prakash AS,Barnard R,Chiswell B,Ng JC

更新日期：2002-07-07 00:00:00

abstract：:Lead (Pb) exposure during development impairs a variety of cognitive, behavioral and neurochemical processes resulting in deficits in learning, memory, attention, impulsivity and executive function. Numerous studies have attempted to model this effect of Pb in rodents, with the majority of studies focusing on hippocam...

journal_title：Toxicology letters

authors： Anderson DW,Mettil W,Schneider JS

更新日期：2016-03-30 00:00:00

abstract：:To understand environmental causes of disease, unbiased methods are needed to characterize the human exposome, which represents all toxicants to which people are exposed from both exogenous and endogenous sources. Because they directly modify DNA and important proteins, reactive electrophiles are probably the most imp...

journal_title：Toxicology letters

authors： Rappaport SM,Li H,Grigoryan H,Funk WE,Williams ER

更新日期：2012-08-13 00:00:00

abstract：:Melamine (MA) exposure causes male reproductive toxicity, however, the mechanism remains unclear. In this study, we investigated the roles of the blood-testis barrier (BTB) in MA-induced reproductive toxicity in piglets. Male weaned piglets were exposed to MA concentrations of 0, 100, 300, and 1000 mg/kg in the diet f...

journal_title：Toxicology letters

authors： Chang L,Lu Z,Li D,Zhang L,Wang Z,Du Q,Huang Y,Zhao X,Tong D

更新日期：2018-10-15 00:00:00

abstract：:A number of zero tolerance provisions are contained in both food and animal feed law, e.g. for chemical substances whose occurrence is not permitted or is directly prohibited in food or animal feed. In the European Union, bans of this kind were introduced to give consumers and animals the greatest possible protection ...

journal_title：Toxicology letters

authors： Heberer T,Lahrssen-Wiederholt M,Schafft H,Abraham K,Pzyrembel H,Henning KJ,Schauzu M,Braeunig J,Goetz M,Niemann L,Gundert-Remy U,Luch A,Appel B,Banasiak U,Böl GF,Lampen A,Wittkowski R,Hensel A

更新日期：2007-12-10 00:00:00

abstract：:Di-(2-ethylhexyl)-phthalate (DEHP) is a phthalate ester that binds peroxisome proliferator-activated receptor α (PPARα) to induce proliferation of peroxisomes and regulate the expression of specific target genes. The question of whether the effect of DEHP on female reproductive processes is mediated via PPARα-dependen...

journal_title：Toxicology letters

authors： Kawano M,Qin XY,Yoshida M,Fukuda T,Nansai H,Hayashi Y,Nakajima T,Sone H

更新日期：2014-08-04 00:00:00

abstract：:Subchronic oral toxicity of turmeric and ethanolic turmeric extract was studied in female Swiss mice and Wistar rats fed turmeric (0, 1 and 5%) and ethanolic turmeric extract (0, 0.05 and 0.25%) through diet for 14 and/or 90 days. The administration of a high dose of turmeric (5%) for longer duration (90 days) showed ...

journal_title：Toxicology letters

authors： Deshpande SS,Lalitha VS,Ingle AD,Raste AS,Gadre SG,Maru GB

更新日期：1998-05-01 00:00:00

abstract：:1. The oocyte of the African clawed toad (Xenopus laevis) offers a reliable, sensitive and disease resistant system to investigate recombinantly and endogenously expressed Ca2+ signaling G protein-coupled receptors and their intracellular signaling pathways. 2. To study receptor induced Ca2+ release, two-electrode vol...

journal_title：Toxicology letters

authors： Nietgen GW,Hönemann CW,Durieux ME

更新日期：1998-11-23 00:00:00

abstract：:The E-rosetting profiles of T-cells were studied in 47 subjects with a history of poly-drug and alcohol abuse, and compared with 15 normal controls. No change was evident in numbers of total rosette-forming cells (TRFC). However, there was reduction in active and high-affinity rosette-forming cells (ARFC and HARFC). T...

journal_title：Toxicology letters

authors： Nair BS,Erickson JR,Pillai R,Estrada A,Watson RR

更新日期：1991-08-01 00:00:00

abstract：:Many xenobiotics and carcinogens are oxidized in vitro by prostaglandin-H synthase (PHS) in the presence of arachidonic acid or lipid peroxides. PHS has been suggested to serve as an alternative metabolic activation enzyme to the cytochrome P-450 isoenzymes, particularly in tissues low in monooxygenase activity. This ...

journal_title：Toxicology letters

authors： Degen GH

更新日期：1993-04-01 00:00:00

abstract：:Antioxidants of the vitamin E family have protective effects against metal toxicity. We examined the protective effect of racemic LLU-alpha [2,7,8-trimethyl-2-(carboxyethyl)-6-hydroxychroman] a metabolite of gamma-tocopherol, in comparison to the effect of alpha- and gamma-tocopherol in rats treated with sodium dichro...

journal_title：Toxicology letters

authors： Appenroth D,Karge E,Kiessling G,Wechter WJ,Winnefeld K,Fleck C

更新日期：2001-07-06 00:00:00

abstract：:Sex difference was observed in the aryl hydrocarbon hydroxylase (AHH) activity of liver in the C3H/He strain of mice. Treatment with estradiol showed an increase in AHH activity in gonadectomized female mice, but not in males. Testosterone, however, lowered AHH activity in both the gonadectomized male and female. Foll...

journal_title：Toxicology letters

authors： Watanabe M,Tamura Y,Abe T

更新日期：1980-01-01 00:00:00

abstract：:Anthocyanins are plant pigments occurring in flowers and berry fruits. Since a phenomenon of food-drug interactions is increasingly emerging, we examined the effects of 21 major anthocyanins and the extracts from 3 food supplements containing anthocyanins on the aryl hydrocarbon receptor (AhR)-cytochrome P450 CYP1A1 s...

journal_title：Toxicology letters

authors： Kamenickova A,Anzenbacherova E,Pavek P,Soshilov AA,Denison MS,Zapletalova M,Anzenbacher P,Dvorak Z

更新日期：2013-07-31 00:00:00

abstract：:PFAS are man-made compounds that are highly spread in the environment. Human dietary exposure to such contaminants is of high concern as they may accumulate in the food chain. Different studies already demonstrated the importance of the fish consumption in the dietary exposure of these molecules and the potential incr...

journal_title：Toxicology letters

authors： Denys S,Fraize-Frontier S,Moussa O,Le Bizec B,Veyrand B,Volatier JL

更新日期：2014-12-01 00:00:00

abstract：:The utility of HepaRG cells as an in vitro cell-based assay system for assessing drug-induced liver injury (DILI) risk was investigated. Seventeen DILI-positive and 15 DILI-negative drugs were selected for the assay. HepaRG cells were treated with each drug for 24h at concentrations that were 1.6-, 6.3-, 25-, and 100-...

journal_title：Toxicology letters

authors： Tomida T,Okamura H,Satsukawa M,Yokoi T,Konno Y

更新日期：2015-07-02 00:00:00