Abstract:
:Subchronic oral toxicity of turmeric and ethanolic turmeric extract was studied in female Swiss mice and Wistar rats fed turmeric (0, 1 and 5%) and ethanolic turmeric extract (0, 0.05 and 0.25%) through diet for 14 and/or 90 days. The administration of a high dose of turmeric (5%) for longer duration (90 days) showed a significant reduction in body weight gain, alterations in absolute and/or relative liver weights, and hepatotoxicity i.e. focal necrosis or focal necrosis with regeneration both in mice and rats. In mice lower doses of turmeric i.e 0.2 or 1% for 14 days also showed hepatotoxicity and they were found to be more vulnerable to turmeric-induced hepatotoxicity than rats.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Deshpande SS,Lalitha VS,Ingle AD,Raste AS,Gadre SG,Maru GBdoi
10.1016/s0378-4274(98)00035-6subject
Has Abstractpub_date
1998-05-01 00:00:00pages
183-93issue
3eissn
0378-4274issn
1879-3169pii
S0378427498000356journal_volume
95pub_type
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