Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats.

Abstract:

:Subchronic oral toxicity of turmeric and ethanolic turmeric extract was studied in female Swiss mice and Wistar rats fed turmeric (0, 1 and 5%) and ethanolic turmeric extract (0, 0.05 and 0.25%) through diet for 14 and/or 90 days. The administration of a high dose of turmeric (5%) for longer duration (90 days) showed a significant reduction in body weight gain, alterations in absolute and/or relative liver weights, and hepatotoxicity i.e. focal necrosis or focal necrosis with regeneration both in mice and rats. In mice lower doses of turmeric i.e 0.2 or 1% for 14 days also showed hepatotoxicity and they were found to be more vulnerable to turmeric-induced hepatotoxicity than rats.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Deshpande SS,Lalitha VS,Ingle AD,Raste AS,Gadre SG,Maru GB

doi

10.1016/s0378-4274(98)00035-6

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

183-93

issue

3

eissn

0378-4274

issn

1879-3169

pii

S0378427498000356

journal_volume

95

pub_type

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