Abstract：
:Rats (Fisher, Wistar, Donryu and Sprague-Dawley strains) were exposed to 5 approximately 3500 ppm toluene for 8 h, and urine samples were analyzed for hippuric acid and cresols. While hippuric acid increased in proportion to the exposure concentration, a sharp increase in o-cresol excretion was observed at high toluene concentrations so that the o-cresol/hippuric acid ratio was elevated after 500 approximately 3500 ppm exposures. Changes in the p-cresol: hippuric acid ratio were less marked. There were strain differences in toluene metabolism. Fisher rats were highest and Sprague-Dawley rats lowest in o-cresol excretion and in the o-cresol: hippuric acid ratio, whereas Wistar rats excreted p-cresol most abundantly.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Inoue O,Seiji K,Ishihara N,Kumai M,Ikeda Mdoi
10.1016/0378-4274(84)90134-6subject
Has Abstractpub_date
1984-11-01 00:00:00pages
249-57issue
2eissn
0378-4274issn
1879-3169pii
0378-4274(84)90134-6journal_volume
23pub_type
杂志文章abstract：:Sulphur mustard (SM) is a blistering agent that causes debilitating damage to the skin, eyes and respiratory system. In cases of severe exposure, immunodepletion can occur as well as death, due to secondary infections. The toxicity of SM is thought to be mediated in part by the alkylation of nucleic acids and proteins...
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更新日期：2015-01-05 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2017-11-05 00:00:00
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pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2003.10.002
更新日期：2004-01-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2013-04-26 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.01.016
更新日期：2016-03-14 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：2003-04-11 00:00:00
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journal_title：Toxicology letters
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更新日期：2010-10-05 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2004-10-10 00:00:00
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更新日期：1997-05-16 00:00:00
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pub_type： 杂志文章
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更新日期：2012-07-20 00:00:00
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更新日期：1998-12-28 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.02.018
更新日期：2016-04-25 00:00:00
abstract：:Trihalomethanes (THMs; chloroform, bromoform, bromodichloromethane, dibromochloromethane), formed as by-products of chlorine disinfection, are found to occur in combination in drinking water supplies. THMs are metabolized by cytochromes P-450 and are likely substrates of CYP2E1. Therefore, it is possible that mixed ex...
journal_title：Toxicology letters
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更新日期：1999-05-20 00:00:00
