Abstract：
:The direct or indirect interference with GABA-mediated neurotransmission results in convulsive seizure activity in humans and experimental animals. When this convulsant effect is experimentally analyzed, it turns out to be a product of discrete and restricted cerebral sites of drug action. Depending upon the brain circuitry affected, different convulsant patterns are produced. Acute interference with GABA transmission in convulsant trigger sites in the forebrain evokes convulsant seizures which can be clearly distinguished from those evoked by interference with GABA transmission in the hindbrain convulsant sites. While acute alterations of forebrain seizure susceptibility do not change hindbrain seizure susceptibility, chronic or repeated exposure to seizures may cause simultaneous "kindling" of both systems. In addition to the specific convulsant sites of action of GABA antagonists in the brain there are specific sites where GABA antagonists exert an anticonvulsant action. The ability of a chemical agent to evoke a convulsive seizure by interfering with GABA transmission depends upon the relative effect of the agent on GABA transmission in different brain areas as well as its effect on other excitatory and inhibitory neurotransmitters with which GABA interacts.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Gale Kdoi
10.1016/0378-4274(92)90215-6keywords:
subject
Has Abstractpub_date
1992-12-01 00:00:00pages
417-28eissn
0378-4274issn
1879-3169pii
0378-4274(92)90215-6journal_volume
64-65 Spec Nopub_type
杂志文章,评审abstract：:Behavioral toxicology is an emerging field which is becoming increasingly important in risk assessment of exposure to neurotoxic substances, due to the high sensitivity of behavior towards neurotoxic action and the integration in behavioral functions of several underlying processes and neurofunctions, such as motor, s...
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更新日期：2012-05-05 00:00:00
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更新日期：1995-01-01 00:00:00
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更新日期：2004-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-02-26 00:00:00
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更新日期：1991-04-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1991-08-01 00:00:00
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更新日期：2003-04-04 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1994-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：1988-07-01 00:00:00
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更新日期：2019-06-01 00:00:00
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更新日期：2016-03-30 00:00:00
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更新日期：2020-01-01 00:00:00
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更新日期：2014-09-17 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：2014-12-01 00:00:00
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更新日期：1992-12-01 00:00:00
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更新日期：2018-03-15 00:00:00
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pub_type： 杂志文章
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更新日期：2013-04-26 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.toxlet.2003.10.029
更新日期：2004-03-21 00:00:00
abstract：:Methamphetamine (METH) is a widely abused psychostimulant. Lactulose is a non-absorbable sugar, which effectively decreases METH-induced neurotoxicity in rat. However, the exact mechanisms need further investigation. In this study, 5-week-old male Sprague Dawley rats received METH (15 mg/kg, 8 intraperitoneal injectio...
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pub_type： 杂志文章
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更新日期：2018-06-01 00:00:00
