Abstract:
:Hexachlorobenzene (HCB) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) kinetics were compared in rats before, during and after partial starvation. Food restriction produced a drastic mobilization of the residues stored in the adipose tissue resulting in symptoms of neurotoxicity. The redistribution was reversible and did not produce a significant reduction in the chemicals body burden. HCB and p,p'-DDE, although both highly lipophilic, showed important differences in their blood transport and distribution pattern, with more HCB being transported by red blood cells and with a greater facility for HCB to reach the liver and the brain.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
To-Figueras J,Gómez-Catalán J,Rodamilans M,Corbella Jdoi
10.1016/0378-4274(88)90105-1subject
Has Abstractpub_date
1988-07-01 00:00:00pages
79-86issue
1eissn
0378-4274issn
1879-3169pii
0378-4274(88)90105-1journal_volume
42pub_type
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