Abstract:
:Micronucleus (MN) induction by azidothymidine (AZT) in B and T lymphocytes was analyzed by a recently developed MAC (morphology-antibody-chromosome) method which allows the immunologic identification of different cell lineages. An increased frequency of MN in AZT-treated cultures compared with controls was observed. CD4 cells were found to be more sensitive to AZT damage. AZT-treated cultures showed a significant decrease in the proportion of CD4 interphasic cells. Furthermore, higher MN frequencies in isolated lymphocytes than in whole blood in both control and AZT-treated cultures were observed.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Stern M,Cid MG,Larripa I,Slavutsky Idoi
10.1016/0378-4274(94)90167-8subject
Has Abstractpub_date
1994-02-01 00:00:00pages
235-42issue
2eissn
0378-4274issn
1879-3169pii
0378-4274(94)90167-8journal_volume
70pub_type
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pub_type: 杂志文章,多中心研究
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