Abstract：
:Palytoxins (PLTXs) are known seafood contaminants and their entrance into the food chain raises concern about possible effects on human health. The increasing number of analogs being identified in edible marine organisms complicates the estimation of the real hazard associated with the presence of PLTX-like compounds. So far, 42-OH-PLTX is one of the few congeners available, and the study of its toxicity represents an important step toward a better comprehension of the mechanism of action of this family of compounds. From this perspective, the aim of this work was to investigate the in vivo and in vitro effect of 42-OH-PLTX on skeletal muscle, one of the most sensitive targets for PLTXs. Our results demonstrate that 42-OH-PLTX causes damage at the skeletal muscle level with a cytotoxic potency similar to that of PLTX. 42-OH-PLTX induces cytotoxicity and cell swelling in a Na(+)-dependent manner similar to the parent compound. However, the limited Ca(2+)-dependence of the toxic insult induced by 42-OH-PLTX suggests a specific mechanism of action for this analog. Our results also suggest an impaired response to the physiological agonist acetylcholine and altered cell elasticity.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Del Favero G,Sosa S,Poli M,Tubaro A,Sbaizero O,Lorenzon Pdoi
10.1016/j.toxlet.2013.12.020subject
Has Abstractpub_date
2014-03-03 00:00:00pages
285-93issue
2eissn
0378-4274issn
1879-3169pii
S0378-4274(13)01483-5journal_volume
225pub_type
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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pub_type： 杂志文章
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pub_type： 杂志文章
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