Abstract:
:The effects of sodium tellurite 0.1 and 0.4 mg/kg were assessed in the Morris water maze. Two days after treatment rats were tested for acquisition (posttreatment days 3-6) and on seventh day on a spatial retention task. Tellurium treatment was found to cause significant impairment in retention of the spatial learning task. Locomotor disturbances were not the cause of the observed effects. Ultrastructural observations showed neuropathological changes in hippocampus subfields and prefrontal cortex with swelling of synapses, astrocytes and astrocytic processes around the vessels in the cerebral cortex neuropil. Severity of the observed changes in glial-neuronal unit was in correlation with the extent of learning impairment. A direct injury of Schwann cells with the secondary myoclasis was noted in the sciatic nerve. Our results indicate that acute treatment with sodium tellurite results in impairment of learning and spatial memory.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Widy-Tyszkiewicz E,Piechal A,Gajkowska B,Smiałek Mdoi
10.1016/s0378-4274(02)00050-4keywords:
subject
Has Abstractpub_date
2002-05-28 00:00:00pages
203-14issue
3eissn
0378-4274issn
1879-3169pii
S0378427402000504journal_volume
131pub_type
杂志文章abstract::Bisphenol A (BPA) has been acknowledged as an estrogenic chemical able to interact with human estrogen receptors (ER). Many lines of evidence reveal that BPA has an impact as an endocrine disruptor even at low doses. However, its binding to ER and hormonal activity is extremely weak, making the intrinsic significance ...
journal_title:Toxicology letters
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更新日期:2006-12-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Toxicology letters
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更新日期:1987-04-01 00:00:00
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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更新日期:2014-12-01 00:00:00
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journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章
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journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2009-09-10 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1999-09-05 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章,评审
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更新日期:1995-09-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2002-07-21 00:00:00