Abstract：
:The assessment of human exposure to chemicals present in the diet is a rapidly developing discipline. The formulation of the "risk analysis paradigm" by the Codex Alimentarius Commission in 1994 defined the exposure assessment as an essential step of the risk assessment process. This has re-enforced demands to those joint FAO/WHO scientific bodies who evaluate the safety of chemicals in foods to estimate routinely intakes for food additives, flavors, contaminants, and residues of pesticides and veterinary drugs as part of their safety assessments. The approaches chosen by the Joint FAO/WHO Expert Committee for Food Additives (JECFA) and the Joint FAO/WHO Expert Meeting on Pesticide Residues (JMPR) for these compounds are considerably different. These differences can only be understood when considering the different risk policies of the Codex Alimentarius Committees involved. Specific problems emerge if global intake assessments are requested; lack of representative regional data for consumption patterns and insufficient knowledge about levels of chemicals occurring in foods in many countries bear the risk that exposure assessments do not provide risk managers with a true global picture. There is a need to improve the collection and dissemination of such data.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Luetzow Mdoi
10.1016/s0378-4274(03)00038-9keywords:
subject
Has Abstractpub_date
2003-04-11 00:00:00pages
419-25eissn
0378-4274issn
1879-3169pii
S0378427403000389journal_volume
140-141pub_type
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journal_title：Toxicology letters
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更新日期：1983-04-01 00:00:00
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journal_title：Toxicology letters
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更新日期：1994-01-01 00:00:00
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journal_title：Toxicology letters
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更新日期：2019-06-01 00:00:00
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更新日期：2010-12-15 00:00:00
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pub_type： 杂志文章
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更新日期：2012-08-13 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2017-05-05 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：2000-03-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2015.09.020
更新日期：2015-12-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(01)00441-6
更新日期：2001-12-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1984-06-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(89)90132-x
更新日期：1989-03-01 00:00:00
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journal_title：Toxicology letters
pub_type： 临床试验,杂志文章
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更新日期：2007-08-01 00:00:00
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更新日期：1983-12-01 00:00:00
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journal_title：Toxicology letters
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更新日期：1980-03-01 00:00:00
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更新日期：2014-08-17 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1980-10-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1983-08-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1980-02-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2011-09-10 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2009-01-10 00:00:00
abstract：:Although building constructions are a recurring part of urbanization, the health risk of particulate matters (PM) originating from such activities have seldom been subjected to detailed studies. We sought to characterize the relative risk of air borne PM collected from different heights (ground and top floor) of a bui...
journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2015-11-04 00:00:00
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更新日期：2011-09-10 00:00:00
abstract：:Betulinic acid (BA) is known to induce apoptosis in melanoma neuroectodermal and malignant brain cancer cell lines. Present report describes the role of antioxidants on the BA-induced toxicity to human cell line SK-N-MC. Hydrophilic antioxidants viz., L-ascorbic acid (VitC) and N-acetyl-L-cysteine (l-NAC) had no prote...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2004.03.027
更新日期：2004-11-02 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2010.04.004
更新日期：2010-07-01 00:00:00
abstract：:The changes in hepatic metallothionein (MT) and glutathione levels and cadmium distribution were investigated 72 hr after a subcutaneous administration of 1.5 mg Cd2+/kg as CdCl2H2O to normal and partially hepatectomized rats. Partial hepatectomy had no effect on native metallothionein content. Cadmium and MT content ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(82)90195-3
更新日期：1982-06-01 00:00:00
