Detection of chemically induced renal injury: the cascade of degenerative morphological and functional changes that follow the primary nephrotoxic insult and evaluation of these changes by in-vitro methods.

Abstract:

:A diversity of chemicals cause discrete lesions in the kidney by a number of different mechanisms, and similar types of chemicals may give rise to more than one target cell injury. Screening for these lesions in vivo may be unreliable if a single noninvasive or invasive criterion is used. Instead, evidence of nephrotoxicity must be based on an array of tests, applied over a period of time. These should include biochemical, pathological and histochemical tests conducted in tandem. A primary toxic injury to the kidney may give rise to recovery, to permanently altered functional reserve or to a clinically identifiable effect, such as acute or chronic renal failure or malignancy. These clinical effects occur as a result of a cascade of degenerative changes which are a consequence of a primary lesion but also affect other parts of the kidney. A number of factors can modulate the progression of the primary insult to the end-effect. In-vitro nephrotoxicity screening is also difficult, but a rational approach can be based on current understanding of how chemicals target for and damage cells in anatomically well-defined regions of the kidney. In-vitro techniques can provide answers to specific questions about the mechanisms by which chemicals damage these discrete cell types. It is essential that a number of different in-vitro systems be developed in parallel to address the mechanistic aspects and screening of nephrotoxicity properly. Data generated in vitro must be related to the situation in vivo and used to devise reliable noninvasive tests for assessing nephrotoxicity in man.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Bach PH

doi

10.1016/0378-4274(89)90132-x

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

237-49

issue

1-3

eissn

0378-4274

issn

1879-3169

pii

0378-4274(89)90132-X

journal_volume

46

pub_type

杂志文章,评审
  • The effect of α-synuclein and Tau in methamphetamine induced neurotoxicity in vivo and in vitro.

    abstract::The upregulated α-synuclein (α-syn) and Tau co-occur in methamphetamine (METH) abusers' brains. Here, we designed experiments mainly to investigate whether α-syn and Tau interact in METH exposure. We detected the expression of α-syn, total Tau, and phosphorylation of Tau at Serine 396 (pSer396 Tau) under in vitro and ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.11.028

    authors: Ding J,Lian Y,Meng Y,He Y,Fan H,Li C,Qiu P

    更新日期:2020-02-01 00:00:00

  • Ovarian toxicity of cigarette smoke exposure during pregnancy in mice.

    abstract::Pregnant mice of C57BL/6 and DBA/2 inbred strains were exposed to cigarette smoke during days 1-18 of pregnancy. Both mothers and offspring were killed at the age of 21-22 weeks, and ovaries were studied with respect to the number of primordial follicles and small primary follicles. In additional studies, 7,12-dimethy...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(85)90103-1

    authors: Vähäkangas K,Rajaniemi H,Pelkonen O

    更新日期:1985-04-01 00:00:00

  • Intestinal absorption of 5 chromium compounds in young black ducks (Anas rubripes).

    abstract::An in vivo intestinal perfusion technique was used to measure the absorption rates of five Cr compounds in black ducks. Cr was absorbed from saline solutions of KCr(SO4)2 and CrO3 at a rate about 1.5 to 2.0 times greater than from solutions of Cr, Cr(NO3)3, and Cr(C5H7O2)3. These results suggest the ionic form of Cr i...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(80)90191-5

    authors: Eastin WC Jr,Haseltine SD,Murray HC

    更新日期:1980-08-01 00:00:00

  • Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in pigs.

    abstract::Plants can metabolize the Fusarium mycotoxin deoxynivalenol (DON) by forming the masked mycotoxin deoxynivalenol-3-β-D-glucoside (D3G). D3G might be cleaved during digestion, thus increasing the total DON burden of an individual. Due to a lack of in vivo data, D3G has not been included in the various regulatory limits...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2014.06.032

    authors: Nagl V,Woechtl B,Schwartz-Zimmermann HE,Hennig-Pauka I,Moll WD,Adam G,Berthiller F

    更新日期:2014-08-17 00:00:00

  • Prolonged phenobarbital pretreatment abolishes the early oxidative stress component induced in the liver by acute lindane intoxication.

    abstract::Lindane administration to rats (60 mg/kg b.w.) led to an enhancement in the oxidative stress status of the liver at 4 h after treatment, characterized by increases in hepatic thiobarbituric acid reactants (TBARS) formation and chemiluminescence, reduced glutathione (GSH) depletion, and diminution in the biliary conten...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(00)00172-7

    authors: Videla LA,Arisi AC,Fuzaro AP,Koch OR,Junqueira VB

    更新日期:2000-04-10 00:00:00

  • Importance of species differences in experimental pulmonary carcinogenicity of inhaled cadmium for extrapolation to humans.

    abstract::There is sufficient evidence for pulmonary carcinogenicity of inhaled cadmium (Cd) compounds in rats whereas no such evidence was found in mice and hamsters, indicating significant species differences in the pulmonary response to inhaled Cd. We hypothesized that expression of metallothionein (MT) protein in the lung a...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)90046-9

    authors: Oberdörster G,Cherian MG,Baggs RB

    更新日期:1994-06-01 00:00:00

  • Comparison of the toxic mechanism of T-2 toxin and deoxynivalenol on human chondrocytes by microarray and bioinformatics analysis.

    abstract::T-2 toxin and deoxynivalenol (DON) are two representative mycotoxins that are commonly found in cereals and agricultural products. As T-2 toxin and DON are considered the cause of Kashin-Beck disease, a special osteoarticular disease, chondrocytes would be a vital target site for these toxins. To fully understand the ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.12.024

    authors: Yang L,Wang S,Zhao G,Wang X,Guo X

    更新日期:2020-03-15 00:00:00

  • Interlaboratory evaluation of a cow's milk allergy mouse model to assess the allergenicity of hydrolysed cow's milk based infant formulas.

    abstract::This study describes two phases of a multi-phase project aiming to validate a mouse model for cow's milk allergy to assess the potential allergenicity of hydrolysed cow's milk based infant formulas (claim support EC-directive 2006/141/E). The transferability and the discriminatory power of this model was evaluated in ...

    journal_title:Toxicology letters

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.toxlet.2013.04.008

    authors: van Esch BC,van Bilsen JH,Jeurink PV,Garssen J,Penninks AH,Smit JJ,Pieters RH,Knippels LM

    更新日期:2013-06-20 00:00:00

  • In vitro effect of aflatoxin B1 on rat liver macrophages (Kuffer cells).

    abstract::The effect of aflatoxin B1 on the uptake and incorporation of [3H]leucine and [3H]uridine and on phagocytosis of latex particles was studied using cultures of rat liver macrophages (Kuffer cells). Aflatoxin B1 inhibited the incorporation of both isotopes, but inhibition of uridine incorporation was greater than that o...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(85)90039-6

    authors: Mohapatra NK,Roberts JF

    更新日期:1985-12-01 00:00:00

  • AZT-induction of micronuclei in human lymphocyte subpopulations.

    abstract::Micronucleus (MN) induction by azidothymidine (AZT) in B and T lymphocytes was analyzed by a recently developed MAC (morphology-antibody-chromosome) method which allows the immunologic identification of different cell lineages. An increased frequency of MN in AZT-treated cultures compared with controls was observed. C...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)90167-8

    authors: Stern M,Cid MG,Larripa I,Slavutsky I

    更新日期:1994-02-01 00:00:00

  • The effect of cyclohexylamine on the embryo following oral administration to mice and rats.

    abstract::The possible embryotoxic effects of cyclohexylamine hydrochloride doses (expressed as free base) of 10, 30 and 100 mg/kg of body weight per day administered orally in water to mice and rats from the 6th to 15th day post-coitum were investigated. Treatment with daily doses of up to 100 mg/kg of body weight to mice and ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(83)90049-8

    authors: Lorke D,Machemer L

    更新日期:1983-06-01 00:00:00

  • Differential effects on the cyanogenic glycoside content of fermenting cassava root pulp by beta-glucosidase and microbial activities.

    abstract::The degradation of cyanogenic glycosides was studied in spontaneously fermenting cassava root pulp and in fresh pulp samples pretreated to prevent either endogenous beta-glycosidase activity, fermentation, or both. The rate of disappearance of the glycosides, as measured by hydrocyanic acid (HCN) production in situ, i...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(83)90153-4

    authors: Maduagwu EN

    更新日期:1983-03-01 00:00:00

  • Toxicokinetics and toxicodynamics of iron poisoning.

    abstract::Iron is a unique poison because it is not a xenobiotic. It is an essential element and highly reactive. Because of the critical dependence upon iron and its potential to damage tissues, elaborate mechanisms have evolved for its efficient absorption, transport, cellular uptake, storage and conservation. These are incom...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(98)00279-3

    authors: Tenenbein M

    更新日期:1998-12-28 00:00:00

  • 3,4,3',4'-Tetrachlorobiphenyl given to mice prenatally produces long-term decreases in striatal dopamine and receptor binding sites in the caudate nucleus.

    abstract::Pregnant CD-1 mice were given 32 mg/kg of 3,4,3',4'-tetrachlorobiphenyl (TCB) or corn oil vehicle, by gavage, on days 10--16 of gestation. At 1 year of age, the offspring were tested for spontaneous motor activity; the mice were then killed and dopamine (DA) levels and specific DA receptor binding were measured in the...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(81)90087-4

    authors: Agrawal AK,Tilson HA,Bondy SC

    更新日期:1981-03-01 00:00:00

  • Disturbance of cellular glucose transport by two prevalently used fluoroquinolone antibiotics ciprofloxacin and levofloxacin involves glucose transporter type 1.

    abstract::Dysglycemia and central nervous system (CNS) complications are the known adverse effects of fluoroquinolone antibiotics. Ciprofloxacin and levofloxacin are among the most prescribed antibiotics. In this study we demonstrate that ciprofloxacin and levofloxacin disturb glucose transport into HepG2 cells and such inhibit...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2008.10.017

    authors: Ge DT,Law PY,Kong SK,Ho YY

    更新日期:2009-01-30 00:00:00

  • Long-term evaluation of organophosphate toxicity and antidotal therapy in co-cultures of spinal cord and muscle tissue.

    abstract::Victims of nerve agents basically require antidotal treatment. There is need for novel antidotes and for therapeutic procedures that are specifically adapted to these patients. To cope with this challenge, in vitro test systems which are easy to handle and allow for conducting long-term studies would be of great benef...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2011.04.010

    authors: Drexler B,Seeger T,Grasshoff C,Thiermann H,Antkowiak B

    更新日期:2011-09-25 00:00:00

  • Polymorphism of glutathione S-transferases and susceptibility to acrylonitrile and dimethylsulfate in cases of intoxication.

    abstract::In this paper, the difficulties of genetic screening of occupationally exposed subjects for the evaluation of retrospective, and prospective, health risk assessments is illustrated with reference to glutathione S-transferase (GST) function. Individual differences in the magnitude and half-life of adduct levels, derive...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(02)00191-1

    authors: Leng G,Lewalter J

    更新日期:2002-08-05 00:00:00

  • Styrene: from characterisation of DNA adducts to application in styrene-exposed lamination workers.

    abstract::Styrene oxide, a metabolite of styrene, reacts with many centres in nucleosides but in DNA N-7-, N2- and O6-guanine are the main sites. A 32P-postlabelling method was developed for the detection of O6-styrene oxide DNA adducts from white blood cells. The method involved use of nuclease P1 and magnet transfer. The O6 a...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审

    doi:10.1016/0378-4274(95)03285-1

    authors: Hemminki K,Vodicka P

    更新日期:1995-05-01 00:00:00

  • A direct peptide reactivity assay using a high-throughput mass spectrometry screening platform for detection of skin sensitizers.

    abstract::Chemical-peptide conjugation is the molecular initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatography/ultraviolet (HPLC/UV) detection method to quantify chemical-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two sy...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2020.12.002

    authors: Wei Z,Fang Y,Gosztyla ML,Li AJ,Huang W,LeClair CA,Simeonov A,Tao D,Xia M

    更新日期:2021-03-01 00:00:00

  • Heavy metal-induced cytotoxicity to cultured human epidermal keratinocytes and effects of antioxidants.

    abstract::Human epidermal keratinocytes which have been cultured were treated with the heavy metal ions of cadmium, mercury, copper and zinc. Cytotoxicity was measured either by protein estimation or by using the neutral red assay. Antioxidants were added in order to find out whether heavy metal-induced cytotoxicity is related ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)90170-8

    authors: Kappus H,Reinhold C

    更新日期:1994-04-01 00:00:00

  • Role of corticosterone in ethyl carbamate-induced immunosuppression in female BALB/c mice.

    abstract::We have recently demonstrated that the antibody response to the T-cell-dependent antigen, sheep red blood cells (SRBCs), was suppressed by ethyl carbamate in female BALB/c mice. At the same doses, ethyl carbamate decreased in the numbers of splenic macrophages, B cells, total T cells, CD4(+) T cells and CD8(+) T cells...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(00)00306-4

    authors: Cha SW,Lee HJ,Cho MH,Lee MH,Koh WS,Han S,Kim J,Lee E,Nam D,Jeong TC

    更新日期:2001-03-08 00:00:00

  • Effects of zinc toxicity on thyroid function and histology in broiler chicks.

    abstract::Mechanisms of zinc (Zn) toxicity are incompletely understood and data regarding potential endocrine alterations in Zn toxicity are scarce. To examine mechanisms of Zn toxicity, day-old chicks were pair-fed diets containing 5280 ppm (Hz) or 73 ppm (CON) Zn. Impaired postnatal growth, independent of feed consumption, an...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(91)90205-k

    authors: Dean CE,Hargis BM,Hargis PS

    更新日期:1991-08-01 00:00:00

  • Lipoxygenase-mediated biotransformation of p-aminophenol in the presence of glutathione: possible conjugate formation.

    abstract::This study tested a hypothesis that soybean lipoxygenase (SLO), a model enzyme, may be capable of generating a glutathione (GSH) conjugate(s) from p-aminophenol (PAP). Horseradish peroxidase was employed as a positive control. GSH depletion or an increase in the absorption at 327 nm with time due to GS-PAP formation w...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(99)00188-5

    authors: Yang X,Kulkarni AP

    更新日期:2000-01-05 00:00:00

  • Curvi-linear relation between acetone in breathing zone air and acetone in urine among workers exposed to acetone vapor.

    abstract::An occupational health study was conducted on 45 acetone-exposed male workers in combination with 343 non-exposed men to examine the quantitative relationship between the intensity of acetone vapor exposure and the concentration of acetone in urine. The time-weighted average acetone concentrations were measured by mea...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(92)90081-t

    authors: Kawai T,Yasugi T,Mizunuma K,Horiguchi S,Iguchi H,Ikeda M

    更新日期:1992-08-01 00:00:00

  • Evaluation of combined toxic effects of GB/GF and efficacy of jielin injection against combined poisoning in mice.

    abstract::A computer program (Q-test) was used to evaluate the combined toxic effects of nerve agent GF and its combined form with sarin (GB/GF) in mice. Efficacy of Jielin Injection, the 2-PAM-containing antidote used successfully in China for the treatment of organophosphate pesticide poisoning, was also evaluated and compare...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(97)00057-x

    authors: Luo C,Liang J

    更新日期:1997-08-22 00:00:00

  • Bardoxolone methyl modulates efflux transporter and detoxifying enzyme expression in cisplatin-induced kidney cell injury.

    abstract::Cisplatin is prescribed for the treatment of solid tumors and elicits toxicity to kidney tubules, which limits its clinical use. Nuclear factor erythroid 2-related factor 2 (Nrf2, NFE2L2) is a critical transcription factor that has been shown to protect against kidney injury through activation of antioxidant mechanism...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2016.07.021

    authors: Atilano-Roque A,Aleksunes LM,Joy MS

    更新日期:2016-09-30 00:00:00

  • Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity.

    abstract::Inflammation is one of the factors that may increase the sensitivity of hepatic cells to acetaminophen (APAP) induced toxicity. To investigate the mechanisms, we exposed 3-dimensional (3D) Human Liver Microtissues, a co-culture of primary human hepatocytes (PHH) and Kupffer cells (KCs), to 0, 0.5 (low), 5 (median) and...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.05.004

    authors: Jiang J,Messner S,Kelm JM,van Herwijnen M,Jennen DGJ,Kleinjans JC,de Kok TM

    更新日期:2019-09-15 00:00:00

  • Hemoglobin adducts as biomarkers of estrogen homeostasis: elevation of estrogenquinones as a risk factor for developing breast cancer in Taiwanese women.

    abstract::The aim of this study was to establish a methodology to analyze estrogen quinone-derived adducts, including 17β-estradiol-2,3-quinone (E2-2,3-Q) and 17β-estradiol-3,4-quinone (E2-3,4-Q), in human hemoglobin (Hb). The methodology was then used to measure the levels of these adducts in Hb derived from female breast canc...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2014.01.004

    authors: Lin C,Hsieh WC,Chen DR,Kuo SJ,Yu WF,Hu SW,Sue HJ,Ko MH,Juan CH,Chung KS,Lin PH

    更新日期:2014-03-21 00:00:00

  • Decreased formation of ethoxyacetic acid from ethylene glycol monoethyl ether and reduced atrophy of testes in male rats upon combined administration with toluene and xylene.

    abstract::Male painters are commonly exposed to ethylene glycol monoethyl ether (EGE), a well known reproductive toxic agent causing testicular atrophy, in the form of solvent mixture containing toluene (TOL) and xylene (XYL). This study was carried out to determine the effect of exposing male rats to solvent mixture containing...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(98)00357-9

    authors: Chung WG,Yu IJ,Park CS,Lee KH,Roh HK,Cha YN

    更新日期:1999-01-11 00:00:00

  • Exposure to cyanide following a meal of cassava food.

    abstract::Exposure to cyanide from gari, a popular cassava food in West Africa, is implicated in the causation of ataxic polyneuropathy and amblyopia, but this has been questioned because cyanide was not detected in gari in a study. This study was carried out to determine if gari is a source of exposure to cyanide. Gari (150 g)...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(02)00232-1

    authors: Oluwole OS,Onabolu AO,Sowunmi A

    更新日期:2002-09-05 00:00:00