Abstract：
:The genotoxicity of cypermethrin, a synthetic pyrethroid insecticide, has been studied in vivo in mice. Bone marrow chromosome aberrations were not dose, time or route dependent, but most of the results differed significantly from controls except after 6 and 24 h of treatment using the i.p. and s.c. routes, respectively. In the micronucleus test, the occurrence of polychromatic erythrocytes with micronuclei increased slightly with dose, but was significantly higher than controls at all dose levels. Only a marginal difference in the incidence of sperm abnormalities was noted with the three doses of cypermethrin tested. However, all results differed significantly from the respective control values.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Bhunya SP,Pati PCdoi
10.1016/0378-4274(88)90058-6subject
Has Abstractpub_date
1988-06-01 00:00:00pages
223-30issue
3eissn
0378-4274issn
1879-3169pii
0378-4274(88)90058-6journal_volume
41pub_type
杂志文章abstract：:Sublethal exposure to the organochlorine pesticide, dieldrin, decreased the T-cell immune response in mice. Indeed, a transient inhibition of the mixed lymphocyte reactivity (MLR) was noted at 7 days after intraperitoneal exposure to 0.6 LD50 dieldrin. The present study was undertaken to further investigate the effect...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(88)90003-3
更新日期：1988-04-01 00:00:00
abstract：:The toxicity of benz (e) acephenanthrylene (BeA) has been studied earlier with regard to the carcinogenicity of its metabolites, but its phototogenotoxicity is not well understood. Present study aimed to analyze the photodynamic response of BeA in human skin cell line (A375) under ambient environmental intensity of UV...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2010.08.023
更新日期：2010-11-30 00:00:00
abstract：:The binding of bisphenol A (BPA) and its halogenated derivatives (halogenated BPAs) to mouse peroxisome proliferator-activated receptor α ligand binding domain (mPPARα-LBD) was examined by a combination of in vitro investigation and in silico simulation. Fluorescence polarization (FP) assay showed that halogenated BPA...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2017.11.004
更新日期：2018-02-01 00:00:00
abstract：:Sensitivity to chemicals is a toxicological concept, contained in the dose-response relationship. Sensitivity also includes the concept of hypersensitivity, although controversy surrounds the nature of effects from very low exposures. The term multiple chemical sensitivity has been used to describe individuals with a ...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/s0378-4274(01)00536-7
更新日期：2002-03-10 00:00:00
abstract：:Chlorpyrifos (CHP), an OP-based pesticide, induces hypothermia in the rat followed by a fever that persists for several days. The cytokine, tumor necrosis factor-alpha (TNF), is induced by lipopolysaccharide (LPS) and released during fever and has both pyrogenic and cryogenic (i.e. antipyretic) properties. Administeri...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(99)00122-8
更新日期：1999-09-20 00:00:00
abstract：:A major issue of inhalation toxicity is that of dose. An inhaled dose is more difficult to determine than the dose from other routes of administration. Via oral or parenteral routes, a discrete amount of test substance is given in a bolus. In inhalation toxicology, the delivered dose depends on the exposure concentrat...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/s0378-4274(03)00077-8
更新日期：2003-04-11 00:00:00
abstract：:Betel quid chewing, which contributes high concentration of safrole in saliva, is a popular oral habit in Taiwan. Safrole is a documented rodent hepatocarcinogen, yet its hepatocarcinogenic potential in human is not known. Here, we used LC/ESI-ITMS(n) and LC/QTOF-MS confirmed safrole-dGMP as reference standard to dete...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2008.09.013
更新日期：2008-12-15 00:00:00
abstract：:Welding fumes contain various toxic metals including chromium (Cr), nickel (Ni) and manganese (Mn). An assessment of the risk to health of local and systemic exposure to welding fumes requires the assessment of both external and internal doses. The aims of this study were to test the relevance in small and medium size...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.09.008
更新日期：2014-12-01 00:00:00
abstract：:Serum corticosterone levels were determined at intervals after i.p. injection of 1.8 mg cadmium (Cd)/kg body weight. Thymus weight decreased significantly 3 days after injection. The effect of Cd injection on serum corticosterone levels was almost indistinguishable from that of saline injection. Further, Cd-induced th...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(82)90244-2
更新日期：1982-08-01 00:00:00
abstract：:Plants can metabolize the Fusarium mycotoxin deoxynivalenol (DON) by forming the masked mycotoxin deoxynivalenol-3-β-D-glucoside (D3G). D3G might be cleaved during digestion, thus increasing the total DON burden of an individual. Due to a lack of in vivo data, D3G has not been included in the various regulatory limits...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.06.032
更新日期：2014-08-17 00:00:00
abstract：:To clarify a possible mechanism of zinc (Zn)-induced tolerance to cadmium (Cd) toxicity on bone formation, femurs from 9-day-old chick embryos were cultured for 6 days by the roller-tube method in the presence of Cd (2, 4 or 9 microM) and/or Zn (60 microM). Zn prevented a decrease in bone growth caused by Cd at 4 and ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(88)90149-x
更新日期：1988-11-01 00:00:00
abstract：:Occupational exposure to thallium (Tl+) is known to be responsible for severe neurological manifestations in humans, including ataxia and paralysis; however, little is known yet about the precise mechanism of toxicity elicited by this heavy metal at sublethal doses and its brain distribution after chronic or subchroni...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(00)00200-9
更新日期：2000-07-27 00:00:00
abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an environmental toxin that induces apoptosis of neurons and a pro-inflammatory response in microglial cells. First, we found that TCDD induced proliferation of HAPI microglial cells in a dose- and time-dependent manner. Flow cytometry analysis showed that this proliferati...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.11.003
更新日期：2014-01-30 00:00:00
abstract：:The elution profile of urine from rats given 63Ni i.p. using a Sephadex G-25 column was studied to investigate the chemical form and pattern of nickel (Ni) excretion. Ni was excreted probably as a mixture of complexes with chemical constituents of urine (molecular weight 200-250) within 24 h after 63Ni injection. 63Ni...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(80)90064-8
更新日期：1980-03-01 00:00:00
abstract：:Aromatic amines are metabolically activated into mutagenic compounds by both animal and plant systems. The 4-nitro-o-phenylenediamine (NOP) is a well-known direct-acting mutagen whose mutagenic potential can be enhanced by plant metabolism; m-phenylenediamine (m-PDA) is converted to mutagenic products detected by the ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2004.05.011
更新日期：2004-11-02 00:00:00
abstract：:The aim of this study was to determine the toxicokinetics and some effects of 1,1,1-trifluoroethane (HFC-143a) in humans. Nine male volunteers were experimentally exposed to 500ppm HFC-143a for 2h during light physical exercise (50W) in an exposure chamber. Blood, urine and exhaled air were sampled before, during and ...
journal_title：Toxicology letters
pub_type： 临床试验,杂志文章
doi：10.1016/j.toxlet.2007.05.010
更新日期：2007-08-01 00:00:00
abstract：:We reported earlier that the activation of free-radical-mediated tumor necrosis factor-alpha (TNF-alpha) cascade is the major pathway in the inflammatory lung disease induced by 2-chloroethyl ethyl sulfide (CEES), a mustard gas analog. TNF-alpha induces activating protein 1 (AP-1) activation via phosphorylation of mit...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2008.07.005
更新日期：2008-09-26 00:00:00
abstract：:Monosodium glutamate (MSG) was administered to adult male mice for 6 d at dose levels of 2, 4 and 8 mg/g b.w. Dose levels of 4 and 8 mg/g MSG resulted in significant changes in serum total lipids, triglycerides, phospholipids, free fatty acids and blood glucose 31 d after cessation of exposure. Administration of 2 mg/...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(89)90009-x
更新日期：1989-02-01 00:00:00
abstract：:Recently, spermatogenic cell apoptosis was shown to play a key role in the induction of testicular atrophy by dibutyl phthalate (DBP), thus causing reproductive toxicology. However, the molecular events induced by DBP in apoptotic germ cells remain unclear. In the present study, the mouse spermatocyte-derived GC-2 cel...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.01.016
更新日期：2016-03-14 00:00:00
abstract：:Previous studies in this laboratory have demonstrated that the alpha 2-adrenergic agonist clonidine and related drugs can offer significant protection against both the acute and chronic toxicity to soman administration in rats and mice. The purpose of this study was to determine whether addition of clonidine to a stan...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(90)90042-k
更新日期：1990-08-01 00:00:00
abstract：:1,3-Dinitrobenzene (DNB) causes testicular injury, particularly to Sertoli cells, and induces apoptosis in the surrounding germinal cells in rodents; however, the mechanisms causing this toxicity are poorly understood. Our studies, using standard and molecular tools, were conducted to better understand the pathogenesi...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2012.07.010
更新日期：2012-09-03 00:00:00
abstract：:Staphylococcal enterotoxin A (SEA) is a potent stimulator of CD4+ and CD8+ T cells, the immunotoxic action of which remains unclear. We investigated the in vitro effects of SEA on freshly isolated human peripheral blood lymphocytes depleted of CD8+ T cells. Proliferation and flow cytometry analysis indicated that SEA ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2007.10.009
更新日期：2008-01-04 00:00:00
abstract：:5-Azactydine inhibits cell growth by direct cytotoxic action as well as by inhibition of DNA methyl transferase enzyme. Inhibitors of DNMT have been reported to potentiate the therapeutic activity of cisplatin in vitro. Dose dependent bone marrow toxicity, neurotoxicity and nephrotoxicity are the major side effects of...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2009.08.018
更新日期：2009-12-15 00:00:00
abstract：:In addition to evidence that inhalation of ambient particulate matter (PM) can increase cardiopulmonary morbidity and mortality, the brain may also constitute a site adversely effected by the environmental presence of airborne particulate matter. We have examined the association between exposure to PM and adverse CNS ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2008.03.001
更新日期：2008-05-05 00:00:00
abstract：OBJECTIVE:To evaluate manganese in exhaled breath condensate (Mn-EBC) as an indicator of exposure to fumes from metal inert gas welding process. METHODS:We collected EBC and urine from 17 welders and 16 unexposed control subjects after 5 days exposure. Concentrations of manganese (Mn), nickel (Ni), iron (Fe) and chrom...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.01.034
更新日期：2014-04-07 00:00:00
abstract：:Modulation of the cytochrome P450 (CYP) monooxygenase system by cadmium was investigated in male, adult DBA/2J mice treated with a single dose (16 micromol/kg body weight, i.p.) of cadmium chloride (CdCl2). Total CYP content of liver and kidney microsomes decreased maximally (56% and 85%, respectively) 24 and 18 h, re...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2003.10.029
更新日期：2004-03-21 00:00:00
abstract：:The adverse effects on the immune system resulting from acute and subchronic exposure to immunotoxic compounds can be divided into the following three categories. One is the tissue manifestations induced by either immunosuppressive or immunomodulative compounds through the interactions of the drug or its metabolites w...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(92)90177-l
更新日期：1992-12-01 00:00:00
abstract：:Similar to other types of neuronal degeneration, Parkinson's disease (PD) is characterized by the aggregation of a pathological protein, α-synuclein. The endoplasmic reticulum (ER) is the principal site of protein synthesis, quality control and degradation. Genetic mutants, environmental insults and other factors dist...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/j.toxlet.2020.01.019
更新日期：2020-05-15 00:00:00
abstract：:Traditional gold mining, using metallic mercury (Hg(0)) to form gold amalgam, followed by burning to remove the Hg(0), is widely used in South America, Africa and Asia. The gold is sold to merchants who burn it again to eliminate remaining Hg(0). In Ecuador, 200 gold miners, 37 gold merchants and 72 referents were stu...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2011.09.006
更新日期：2012-08-13 00:00:00
abstract：:New psychoactive substances (NPS) are an increasing problem in clinical and forensic toxicology. The knowledge of their metabolism is important for toxicological risk assessment and for developing toxicological urine screenings. Considering the huge numbers of NPS annually appearing on the market, metabolism studies s...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2017.07.901
更新日期：2017-10-05 00:00:00
