Abstract：
:Similar to other types of neuronal degeneration, Parkinson's disease (PD) is characterized by the aggregation of a pathological protein, α-synuclein. The endoplasmic reticulum (ER) is the principal site of protein synthesis, quality control and degradation. Genetic mutants, environmental insults and other factors disturb ER balance and induce the accumulation of misfolded/unfolded proteins, which initiate ER stress and disturb normal cell function. ER stress perturbs Ca2+ homeostasis and initiates the activation of autophagy and inflammasomes, which have been identified as risk factors for the development of PD. However, the mechanisms by which ER stress contributes to the processed of PD pathogenesis and development remain unclear. This review summarizes current knowledge of ER stress and highlights the principal role of ER stress in PD pathogenesis which may help reveal novel sight to illustrate the pathomechanism of PD.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Mou Z,Yuan YH,Zhang Z,Song LK,Chen NHdoi
10.1016/j.toxlet.2020.01.019subject
Has Abstractpub_date
2020-05-15 00:00:00pages
20-29eissn
0378-4274issn
1879-3169pii
S0378-4274(20)30027-8journal_volume
324pub_type
杂志文章,评审abstract：:Ethylene (ET) is the largest volume organic chemical. Mammals metabolize the olefin to ethylene oxide (EO), another important industrial chemical. The epoxide alkylates macromolecules and has mutagenic and carcinogenic properties. In order to estimate the EO burden in mice, rats, and humans resulting from inhalation e...
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journal_title：Toxicology letters
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pub_type： 杂志文章,评审
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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pub_type： 杂志文章
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1996-12-01 00:00:00
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journal_title：Toxicology letters
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更新日期：2001-03-31 00:00:00
