Abstract：
:The present study investigated the effects of in vitro methylmercury (MeHg) exposure on endogenous dopamine (DA) efflux from mouse striatal slices. MeHg produced a concentration-dependent increase in the spontaneous efflux of DA which was independent of the availability of Ca2+ in the superfusion medium. The Ca(2+)-dependent K(+)-evoked release of DA was significantly enhanced by 50 and 100 microM MeHg. This increase could not be solely accounted for by the MeHg-induced increased in spontaneous DA efflux. The K(+)-stimulated efflux of DA was enhanced by MeHg in both the presence and absence of Ca2+ in the superfusion medium, suggesting that under depolarizing conditions, DA efflux induced by MeHg has a Ca(2+)-independent component. The alterations in DA efflux occurred at concentrations of MeHg previously found in the CNS of animals exhibiting symptoms of MeHg intoxication suggesting that alterations in DA neurotransmission in the striatum may contribute to the symptoms of MeHg toxicity.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Kalisch BE,Racz WJdoi
10.1016/s0378-4274(96)03787-3subject
Has Abstractpub_date
1996-12-01 00:00:00pages
43-9issue
1eissn
0378-4274issn
1879-3169pii
S0378427496037873journal_volume
89pub_type
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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更新日期：2014-04-07 00:00:00
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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doi：10.1016/0378-4274(84)90203-0
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：2002-03-10 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2003.10.002
更新日期：2004-01-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/s0378-4274(98)00233-1
更新日期：1998-12-28 00:00:00
