The accumulation and histological effects of organometallic fungicides Propineb and Maneb in the kidneys of fetus and female rats during pregnancy.

abstract：:Butylated hydroxytoluene (BHT) was administered to mice, from 5 weeks of age of the F0 generation to the weaning of the F2 generation, in the diet at levels of 0 (control), 0.015, 0.045, 0.135, and 0.405%, and some reproductive and neurobehavioural parameters were measured. There was no consistent significant effect o...

journal_title：Toxicology letters

authors： Tanaka T,Oishi S,Takahashi O

更新日期：1993-03-01 00:00:00

abstract：:The U.S. EPA first signalled its intention to use benchmark dose risk techniques in 1991. Subsequently, publication of draft Guidelines for the Risk Assessment of Reproductive Toxicity data indicated the Agency's intention for wide use of the technique. In developmental toxicity experiments, a number of factors need t...

journal_title：Toxicology letters

authors： Foster PM,Auton TR

更新日期：1995-12-01 00:00:00

abstract：:Since cell death by apoptosis is achieved through complex interactions between numerous molecular components, cells may fail to die when stimulated because of molecular abnormalities in the apoptosis pathway or in its control mechanisms. Such inappropriate cell survival is well established when apoptosis is suppressed...

journal_title：Toxicology letters

authors： Williams GT,Critchlow MR,Hedge VL,O'Hare KB

更新日期：1998-12-28 00:00:00

abstract：:In August 2003, 44 victims were poisoned by chemical warfare agents (CWAs) leaked from five drums that were excavated at a construction site in Qiqihar, Northeast China. The drums were abandoned by the former Japanese imperial army during World War II and contained a mixture of Sulfur mustard (SM) and Lewisite. We car...

journal_title：Toxicology letters

authors： Isono O,Kituda A,Fujii M,Yoshinaka T,Nakagawa G,Suzuki Y

更新日期：2018-09-01 00:00:00

abstract：:Inflammation and microRNAs are involved in human skin cancer; however, their molecular mechanisms remain unclear. Further, a concern in skin cancer research is the identification of biomarkers for early diagnosis and accurate prognosis. To explore new biomarkers of chemical exposure in risk assessment of chemical carc...

journal_title：Toxicology letters

authors： Lu X,Luo F,Liu Y,Zhang A,Li J,Wang B,Xu W,Shi L,Liu X,Lu L,Liu Q

更新日期：2015-09-17 00:00:00

abstract：:The effect of two herbicides (paraquat and 2,4-dichlorophenoxybutyric acid) and two fungicides (mancozeb and captafol) was studied on the growth of Flagellospora penicillioides, Lunulospora curvula and Phalangispora constricta using the poisoned-food technique. The pesticides did not produce any inhibition of growth a...

journal_title：Toxicology letters

authors： Chandrashekar KR,Kaveriappa KM

更新日期：1989-09-01 00:00:00

abstract：:An atomic absorption spectrophotometric (AAS) method was successfully applied to analysis of urine for arsenic (As) as a measure of biological monitoring of occupational exposure to As in Vietnam. The application of the method to urine samples from 75 non-exposed control urbanites (after 2-day abstinence from sea food...

journal_title：Toxicology letters

authors： Dang TM,Tran QT,Vu KV

更新日期：1999-09-05 00:00:00

abstract：:Recently, we reported that silver nanoparticles (AgNPs) induced reactive oxygen species (ROS) generation and the resultant oxidative stress contributes to the cell damage associated with AgNPs. 8-Oxoguanine (8-oxoG) is sensitive marker of ROS-induced DNA damage. 8-Oxoguanine DNA glycosylase 1 (OGG1) is an important DN...

journal_title：Toxicology letters

authors： Piao MJ,Kim KC,Choi JY,Choi J,Hyun JW

更新日期：2011-11-30 00:00:00

abstract：:Drug-induced liver injury (DILI) is a major problem in drug development. Although some in vitro methods assessing DILI risk that utilize hepatic cell death or cellular stress as markers have been developed, the predictive ability of these tests is low. In this study, we sought to develop a novel cell-based assay for t...

journal_title：Toxicology letters

authors： Oda S,Matsuo K,Nakajima A,Yokoi T

更新日期：2016-01-22 00:00:00

abstract：:Single doses of primaquine did not produce methemoglobinemia in beagle bitches. Repeated daily administration for 12 days produced a gradually rising level of methemoglobin over that time period, unaccompanied by depletion of erythrocytic reduced glutathione. Primaquine was mutagenic in the Ames test in Salmonella typ...

journal_title：Toxicology letters

authors： Marrs TC,Bright JE,Morris BC

更新日期：1987-05-01 00:00:00

abstract：:Lead (Pb) is a toxic heavy metal widespreadly used in industrial field. Prior studies showed that Pb exposure had detrimental effects on osteoblasts. The mechanisms underlying Pb-induced damage are complex. Autophagy can protect cells from various cytotoxic stimuli. In the present study, the aim of our research was to...

journal_title：Toxicology letters

authors： Lv XH,Zhao DH,Cai SZ,Luo SY,You T,Xu BL,Chen K

更新日期：2015-12-03 00:00:00

abstract：:Benzo(a)pyrene (B(a)P), a potent environmental procarcinogen, has been shown to cause cell cycle alternation. However, the mechanisms involved in this effect are not well understood yet. Our current results demonstrated that B(a)P exposure led to cell proliferation and a 33.5% increase in S phase cells as well as a 26...

journal_title：Toxicology letters

authors： Gao A,Liu B,Shi X,Jia X,Ye M,Jiao S,You B,Huang C

更新日期：2007-04-05 00:00:00

abstract：RATIONALE:The popularity of new and emerging tobacco products such as E-cigarettes (E-cigs) is rapidly expanding worldwide. However, uncertainties surrounding the potential health consequences due to the use of such products exist and warrant further study. METHODS:Cultured A549 and Calu-3 airway epithelia were expose...

journal_title：Toxicology letters

authors： Zhang R,Jones MM,Dornsife RE,Wu T,Sivaraman V,Tarran R,Onyenwoke RU

更新日期：2021-02-01 00:00:00

abstract：:At the present work, different groups of rainbow trouts have been intraperitoneally treated with a polychlorinated biphenyls commercial mixture (Arochlor-1254) at three doses (5, 20 and 70 mg PCBs/ kg body weight) and they have been sampled at 0 (injection moment), 3, 6 and 9 weeks after xenobiotic exposure. Purificat...

journal_title：Toxicology letters

authors： Pérez-López M,Nóvoa-Valiñas MC,Melgar-Riol MJ

更新日期：2002-12-15 00:00:00

abstract：:Small molecular weight chemicals may irritate tissues via the induction of the production of various proinflammatory and chemotactic molecules. The structure of these irritants is heterogenous, as is the pattern of their effects. Chemicals are potentially allergenic (i.e. haptens) when they are able to bind proteins s...

journal_title：Toxicology letters

authors： Kapsenberg ML

更新日期：1996-08-01 00:00:00

abstract：:Spontaneous neoplasms in untreated control CD-1 mice (725 males and 725 females) used in carcinogenicity studies were evaluated and tabulated. The most common neoplasms in male mice were alveolar-bronchiolar adenomas (19.3%) followed by hepatocellular adenomas (11.0%), lymphoreticular neoplasms (6.8%), hepatocellular ...

journal_title：Toxicology letters

authors： Chandra M,Frith CH

更新日期：1992-06-01 00:00:00

abstract：:A low-Mr copper (Cu) and zinc (Zn)-binding protein was present in the liver of a control water lizard Triturus pyrrhogaster. Cadmium (Cd) accumulated in the liver of the animals after intramuscular injections of Cd salt and was bound to Cu- and Zn-binding protein of a single isoform that had properties characteristic ...

journal_title：Toxicology letters

authors： Suzuki KT,Akitomi H,Kawamura R

更新日期：1984-05-01 00:00:00

abstract：:Aluminum phosphide (AlP), a widely used fumigant and rodenticide leads to high mortality if ingested. Its toxicity is due to phosphine liberated when it comes in contact with moisture. The exact mechanism of action of phosphine is not known. In this study male Wistar rats were used. The animals received a single dose ...

journal_title：Toxicology letters

authors： Anand R,Kumari P,Kaushal A,Bal A,Wani WY,Sunkaria A,Dua R,Singh S,Bhalla A,Gill KD

更新日期：2012-11-23 00:00:00

abstract：:Benzidine dihydrochloride administered in water at 0, 30, 60, 120, 200 or 400 ppm to 1664 mice induced a total of 368 hepatocellular carcinomas, of which 34 or 9.2% metastasized to the lungs. Liver tumors which were larger and heavier were more prone to metastasize and all that metastasized contained areas of prominen...

journal_title：Toxicology letters

authors： Frith CH,Baetcke KP,Nelson CJ,Schieferstein G

更新日期：1980-12-01 00:00:00

abstract：:Fusarenon-X (FX), a type B trichothecene mycotoxin, is mainly produced by Fusarium crookwellense, which occurs naturally in agricultural commodities, such as wheat and barley. FX has been shown to exert a variety of toxic effects on multiple targets in vitro. However, the embryonic toxicity of FX in vivo remains uncle...

journal_title：Toxicology letters

authors： Sutjarit S,Nakayama SM,Ikenaka Y,Ishizuka M,Banlunara W,Rerkamnuaychoke W,Kumagai S,Poapolathep A

更新日期：2014-08-17 00:00:00

abstract：:The development of novel alternative testing methods is required to identify the sensitizing capacity of chemicals as a replacement for animal experimentation. We aimed to evaluate in vitro assays as screening tools for detecting skin sensitizers. The murine epidermal keratinocyte cell line HEL-30 was exposed to 16 re...

journal_title：Toxicology letters

authors： Son D,Na Y,Cho WS,Lee BH,Heo Y,Park JH,Seok SH

更新日期：2013-01-10 00:00:00

abstract：:The changes in hepatic metallothionein (MT) and glutathione levels and cadmium distribution were investigated 72 hr after a subcutaneous administration of 1.5 mg Cd2+/kg as CdCl2H2O to normal and partially hepatectomized rats. Partial hepatectomy had no effect on native metallothionein content. Cadmium and MT content ...

journal_title：Toxicology letters

authors： Asokan P

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Vitamin A is widely used in cosmetic preparations. Given that oral Vitamin A and its metabolites present a potential reproductive risk, the present study investigated the effect of topical Vitamin A on human endogenous plasma levels of Vitamin A and its metabolites. METHODS:Two groups of 14 female volunteer...

journal_title：Toxicology letters

authors： Nohynek GJ,Meuling WJ,Vaes WH,Lawrence RS,Shapiro S,Schulte S,Steiling W,Bausch J,Gerber E,Sasa H,Nau H

更新日期：2006-05-05 00:00:00

abstract：:The in vitro interactions of carbaryl and carcinogenic N-nitrosocarbaryl with rat liver microsomal monooxygenase activities are compared. The inhibitory effect of the nitroso-compound is demonstrated to be non-competitive on aminopyrine N-demethylase, p-nitroanisole O-demethylase and aniline hydroxylase. The nature of...

journal_title：Toxicology letters

authors： Beraud M,Forgue MF,Pipy B,Derache P

更新日期：1989-02-01 00:00:00

abstract：:Oxidative stress has been pointed as an important molecular mechanism for liver injury in methylmercury (MeHg) poisoning. Ebselen, a seleno-organic compound that possesses anti-oxidant properties, is a useful therapeutic agent used in clinical situations involving oxidative stress. Here, we examined the possible in vi...

journal_title：Toxicology letters

authors： Farina M,Soares FA,Zeni G,Souza DO,Rocha JB

更新日期：2004-02-02 00:00:00

abstract：:In C57BL/6 mice, aryl hydrocarbon hydroxylase (AHH) increased 1 day after treatment with 3-methylcholanthrene, and induction of UDP-glucuronyl transferases for 3-hydroxybenzo(a)pyrene, p-nitrophenol and bilirubin in the liver microsomes was observed 2 to 5 days later. In DBA/2 mice, neither AHH nor transferase activit...

journal_title：Toxicology letters

authors： Nemoto N,Takayama S

更新日期：1980-01-01 00:00:00

abstract：:Intraperitoneal (i.p.) and intravenous (i.v.) injection of 44Ti in a chloride solution into mice produced no detectable translocation in body fluids. There was no obvious interorgan exchange up to 16 days after injection. The whole body biological retention half-lives had a mean of 642 days for both routes, another in...

journal_title：Toxicology letters

authors： Thomas RG,Archuleta RF

更新日期：1980-07-01 00:00:00

abstract：:The activities of vanadium oxide (V2O3), vanadyl sulfate (VOSO4) and ammonium metavanadate (NH4VO3) in inducing sister chromatid exchange (SCE) and chromosomal aberrations (CAb) were assayed in Chinese hamster ovary cells. The toxic concentrations (TC50) for these compounds were found to be 25, 23 and 16 micrograms el...

journal_title：Toxicology letters

authors： Owusu-Yaw J,Cohen MD,Fernando SY,Wei CI

更新日期：1990-02-01 00:00:00

abstract：:Exposure of humans to xenobiotic mixtures is a continuous state during their everyday routine. However, the majority of toxicological studies assess the in vivo effects of individual substances rather than mixtures. Therefore, our main objective was to evaluate the impact of the 12- and 18-month exposure of rats to a ...

journal_title：Toxicology letters

authors： Fountoucidou P,Veskoukis AS,Kerasioti E,Docea AO,Taitzoglou IA,Liesivuori J,Tsatsakis A,Kouretas D

更新日期：2019-12-15 00:00:00

abstract：:Ambient and biological monitoring was undertaken among tobacco processors who are chronically exposed to tobacco particulates via nasopharyngeal and cutaneous routes. Ambient monitoring revealed that the inspirable dust concentration was 150-fold higher in the tobacco factory than in the control environment, and was a...

journal_title：Toxicology letters

authors： Bhisey RA,Bagwe AN,Mahimkar MB,Buch SC

更新日期：1999-09-05 00:00:00