Methemoglobinogenic potential of primaquine and its mutagenicity in the Ames test.

abstract：:Ethylene (ET) is the largest volume organic chemical. Mammals metabolize the olefin to ethylene oxide (EO), another important industrial chemical. The epoxide alkylates macromolecules and has mutagenic and carcinogenic properties. In order to estimate the EO burden in mice, rats, and humans resulting from inhalation e...

journal_title：Toxicology letters

authors： Filser JG,Klein D

更新日期：2018-04-01 00:00:00

abstract：:The grazing trial at Kidston Gold Mine, North Queensland, was aimed specifically to assess the uptake of metals from the tailing and the potential for unacceptable contamination of saleable meat. Further aims included estimating metal dose rates and identifying potential exposure pathways including plant uptake of hea...

journal_title：Toxicology letters

authors： Bruce SL,Noller BN,Grigg AH,Mullen BF,Mulligan DR,Ritchie PJ,Currey N,Ng JC

更新日期：2003-01-31 00:00:00

abstract：:The mutagenic potential of fluphenazine hydrochloride was tested on male germ cells of Drosophila melanogaster. The criterion used was sex-linked recessive lethal mutations. Oregon-K males of D. melanogaster, reared on a medium containing 0.01, 0.02 and 0.03 mg/ml of the drug, were screened for sex-linked recessive le...

journal_title：Toxicology letters

authors： Rao KP,Rao MS

更新日期：1980-12-01 00:00:00

abstract：:Exposure to polychlorinated biphenyls (PCBs) induce a broad spectrum of toxic effects in various organs including bone. The most susceptible age-groups to the toxic effects of PCBs are foetuses and infants. The aim of the present study was to quantitatively evaluate changes in bone geometry, mineral density and biomec...

journal_title：Toxicology letters

authors： Elabbas LE,Herlin M,Finnilä MA,Rendel F,Stern N,Trossvik C,Bowers WJ,Nakai J,Tuukkanen J,Viluksela M,Heimeier RA,Akesson A,Håkansson H

更新日期：2011-11-10 00:00:00

abstract：:The transition metal cadmium (Cd) is an environmental pollutant which damages the kidneys. Chronic Cd exposure may induce renal fibrosis and/or cancer, but the signaling pathways involved are not understood. The Wnt pathway is a key signaling cascade responsible for renal development, fibrosis and cancer. Hence the ef...

journal_title：Toxicology letters

authors： Chakraborty PK,Scharner B,Jurasovic J,Messner B,Bernhard D,Thévenod F

更新日期：2010-09-15 00:00:00

abstract：:Apoptosis has been described as programmed active cell death. Overexpression of the c-Myc gene has been shown to induce apoptosis in Rat1A/Myc-ER cells when combined with a growth blocking agent. In the present study, we tested whether 4-Hydroxynonenal (HNE) or N-acetyl-L-cysteine (LNAC) affect apoptotic death in seru...

journal_title：Toxicology letters

authors： Yildiz D,Erçal N,Frank RL,Matthews RH

更新日期：1996-12-31 00:00:00

abstract：:Isolated hepatocytes form thiobarbituric acid (TBA)-reactants, a parameter of lipid peroxidation (LPO), when exposed to cadmium (Cd). Paracetamol (Para) inhibits this response, dependent on time and concentration. Cd-induced SH-group decline, however, and enhanced plasma membrane permeability to Trypan Blue (TB) were ...

journal_title：Toxicology letters

authors： Müller L

更新日期：1983-02-01 00:00:00

abstract：:Although the interest is growing towards glyoxalases and methylglyoxal, their role in metabolism is still an enigma. In this paper, the effects of methylglyoxal in both in vivo and in vitro mammalian systems are reviewed and correlated with its interaction with macromolecules (nucleic acids, proteins). The theories on...

journal_title：Toxicology letters

authors： Kalapos MP

更新日期：1994-07-01 00:00:00

abstract：:Butylated hydroxytoluene (BHT) was administered to mice, from 5 weeks of age of the F0 generation to the weaning of the F2 generation, in the diet at levels of 0 (control), 0.015, 0.045, 0.135, and 0.405%, and some reproductive and neurobehavioural parameters were measured. There was no consistent significant effect o...

journal_title：Toxicology letters

authors： Tanaka T,Oishi S,Takahashi O

更新日期：1993-03-01 00:00:00

abstract：:Deoxynivalenol (DON) is a type B trichothecene mycotoxin that exerts multiple toxic effects on plants, animals and humans. Several reports have shown that DON leads to G2/M cell cycle arrest. However, its molecular mechanism is still unclear. In this study, we showed that DON induced strong G2/M cell cycle arrest in H...

journal_title：Toxicology letters

authors： Yuan L,Mu P,Huang B,Li H,Mu H,Deng Y

更新日期：2018-12-15 00:00:00

abstract：:This study was designed to compare the pulmonary cellular proliferative effects of inhaled, size-separated preparations of chrysotile asbestos fibres with similar aerosol fibre concentrations of para-aramid fibrils. Following fibre preparation, rats were exposed for 2 weeks to aerosols of p-aramid fibrils or chrysotil...

journal_title：Toxicology letters

authors： Warheit DB,Hartsky MA,Frame SR

更新日期：1996-11-01 00:00:00

abstract：:Dioxins are a class of extremely toxic environmentally persistent pollutant, comprised of halogenated dibenzo-p-dioxins, dibenzofurans and biphenyls. Despite significant human exposure via multiple routes, very little is known about toxicity induced by dibenzofuran (DF). Current study shed lights on the potential toxi...

journal_title：Toxicology letters

authors： Jaiswal PK,Srivastava S,Gupta J,Thakur IS

更新日期：2012-10-17 00:00:00

abstract：:The effect of methamphetamine cotreatment on carbon tetrachloride-induced liver toxicity was examined in male Sprague-Dawley rats. Concurrent administration of methamphetamine was found to greatly increase the extent of liver injury resulting from carbon tetrachloride treatment, as indicated both by measurement of ser...

journal_title：Toxicology letters

authors： Roberts SM,Harbison RD,Westhouse RA,James RC

更新日期：1995-02-01 00:00:00

abstract：:The effect of carbon monoxide (CO) on pulmonary glutathione-S-transferase (GST) activity was investigated using the isolated perfused rabbit lung (IPRL) preparation. CO at a concentration of 7.5% did not alter the conjugation of glutathione (GSH) with 1,2-epoxy-(p-nitrophenoxy)propane (ENP) in the IPRL. The rate of GS...

journal_title：Toxicology letters

authors： Yang CM,Carlson GP

更新日期：1990-06-01 00:00:00

abstract：:In this paper, the difficulties of genetic screening of occupationally exposed subjects for the evaluation of retrospective, and prospective, health risk assessments is illustrated with reference to glutathione S-transferase (GST) function. Individual differences in the magnitude and half-life of adduct levels, derive...

journal_title：Toxicology letters

authors： Leng G,Lewalter J

更新日期：2002-08-05 00:00:00

abstract：:Although building constructions are a recurring part of urbanization, the health risk of particulate matters (PM) originating from such activities have seldom been subjected to detailed studies. We sought to characterize the relative risk of air borne PM collected from different heights (ground and top floor) of a bui...

journal_title：Toxicology letters

authors： Li H,Fang CH,Shi W,Gurusamy S,Li S,Krishnan MN,George S

更新日期：2015-11-04 00:00:00

abstract：:Epidemiological studies have reported that humans have detectable levels of not only bisphenol A (BPA), but also its halogenated derivatives tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA), in the serum. Our previous study showed that BPA promotes ovarian cancer progression by directly inducing cell p...

journal_title：Toxicology letters

authors： Hoffmann M,Fiedor E,Ptak A

更新日期：2017-03-05 00:00:00

abstract：:N-(3,5-Dichlorophenyl)succinimide (NDPS) induces nephrotoxicity via one or more metabolites which arise from oxidation of the succinimide ring. The purpose of this study was to examine the nephrotoxic potential of N-(3,5-dichlorophenyl)-3-hydroxysuccinamic acid (3-NDHSA), a potential metabolite of NDPS and a positiona...

journal_title：Toxicology letters

authors： Rankin GO,Shih H,Teets VJ,Nicoll DW,Brown PI

更新日期：1989-09-01 00:00:00

abstract：:Monosodium glutamate (MSG) was administered to adult male mice for 6 d at dose levels of 2, 4 and 8 mg/g b.w. Dose levels of 4 and 8 mg/g MSG resulted in significant changes in serum total lipids, triglycerides, phospholipids, free fatty acids and blood glucose 31 d after cessation of exposure. Administration of 2 mg/...

journal_title：Toxicology letters

authors： Ahluwalia P,Malik VB

更新日期：1989-02-01 00:00:00

abstract：:As a main clinical feature of obstructive sleep apnea (OSA), intermittent hypoxia (IH) induces oxidative stress, leading to damage to a variety of organs, including kidney. Metallothionein (MT) is a potent antioxidant that protects kidney against oxidative damage. Our previous studies demonstrated that MT prevented IH...

journal_title：Toxicology letters

authors： Wu H,Zhou S,Kong L,Chen J,Feng W,Cai J,Miao L,Tan Y

更新日期：2015-01-22 00:00:00

abstract：:Guidelines concerning the preclinical safety assessment of therapeutic proteins are available, e.g. in the European Community (EC Notes for Guidance). Unlike rather rigidly prescribing test systems such as those known for chemical substances, it is agreed that for biotechnologically-produced products, testing may be q...

journal_title：Toxicology letters

authors： Bass R,Kleeberg U,Schröder H,Scheibner E

更新日期：1992-12-01 00:00:00

abstract：:Inflammation and microRNAs are involved in human skin cancer; however, their molecular mechanisms remain unclear. Further, a concern in skin cancer research is the identification of biomarkers for early diagnosis and accurate prognosis. To explore new biomarkers of chemical exposure in risk assessment of chemical carc...

journal_title：Toxicology letters

authors： Lu X,Luo F,Liu Y,Zhang A,Li J,Wang B,Xu W,Shi L,Liu X,Lu L,Liu Q

更新日期：2015-09-17 00:00:00

abstract：:Aminoglycosides have detrimental effects on the hair cells of the inner ear, yet these agents indisputably are one of the cornerstones in antibiotic therapy. Hence, there is a demand for strategies to prevent aminoglycoside-induced ototoxicity, which are not available today. In vitro data suggests that the pleiotropic...

journal_title：Toxicology letters

authors： Bächinger D,Horvath L,Eckhard A,Goosmann MM,Honegger T,Gassmann M,Vogel J,Naldi AM

更新日期：2018-07-01 00:00:00

abstract：:Lead is a toxic heavy metal with many recognized adverse health side effects. The central nervous system is the main target of lead toxicity. Although many studies on lead toxicity were conducted, the mechanism of lead toxicity remains uncertain. One possible attribution is the immature blood-brain barrier that causes...

journal_title：Toxicology letters

authors： Yang Y,Zhang X,Fu Y,Yang H

更新日期：2014-06-16 00:00:00

abstract：:Fructose-1,6-diphosphate (FDP) has a salutary effect on hemorrhagic, traumatic and endotoxic shock. The role of FDP on compound 48/80-induced shock was therefore investigated. Sprague Dawley aged male rats (448+/-7.4 gm body weight) were randomly assigned into three groups and treated intraperitoneally with diphenhydr...

journal_title：Toxicology letters

authors： Figueroa AH,Stone RH,Cohly HH,Lehan PH,Markov AK

更新日期：2001-06-20 00:00:00

abstract：:Effective treatments for esophageal squamous cell carcinoma (ESCC), one of the most common cancers in China, are lacking. Longikaurin A (LK-A), an ent-kauranoid diterpenoid isolated from Isodon ternifolius, has been shown to have potent cytotoxic effects on ESCC cells both in vivo and in vitro, mainly by inducing apop...

journal_title：Toxicology letters

authors： Che Y,Wang J,Yuan Z,Li Y,Lu Z,Zhang Z,Zhang J,Wan J,Sun H,Chen Z,Pu J,He J

更新日期：2017-10-05 00:00:00

abstract：:Intraperitoneal injection (50 mg/kg) of 2-nitropropane (2-NP) induced lipid accumulation, centrilobular necrosis, degranulation of rough endoplasmic reticulum, proliferation of smooth endoplasmic reticulum and mitochondrial abnormalities in rat liver 24 h after exposure. These pathological changes were accompanied by ...

journal_title：Toxicology letters

authors： Zitting A,Savolainen H,Nickels J

更新日期：1981-11-01 00:00:00

abstract：:Hypoxia-inducible factor-1alpha (HIF-1alpha) and aryl hydrocarbon receptor (AhR) both require dimerization with AhR nuclear translocator (ARNT) to initiate transcription of their respective target genes. It has been proposed that competition for ARNT results in decreased targeting of AhR to cytochrome P450 1A1 (CYP1A1...

journal_title：Toxicology letters

authors： Allen JW,Johnson RS,Bhatia SN

更新日期：2005-01-15 00:00:00

abstract：:Cataract is the leading cause of blindness with an estimated 16 million people affected worldwide. d-galactose (d-gal) is a reducing sugar that widely distributed in foodstuffs, and studies show that d-gal could promote cataract formation by damaging nature lens epithelial cells (LECs). However, the underlying mechani...

journal_title：Toxicology letters

authors： Xu Y,Li Y,Ma L,Xin G,Wei Z,Zeng Z,Xing Z,Li S,Niu H,Huang W

更新日期：2018-06-01 00:00:00

abstract：:Exercising volunteers exposed in chambers to as little as 80 ppb O3 for several hours exhibit impaired lung function and irritative lower airway symptoms. Comparable changes occur among children and young adults exposed to summer smog containing O3. Intensity of the response is reproducible but varies widely among ind...

journal_title：Toxicology letters

authors： Bromberg PA,Koren HS

更新日期：1995-12-01 00:00:00