Methylglyoxal toxicity in mammals.

abstract：:Tetrachlorobenzyltoluene (TCBT) (Ugilec 141) was investigated in induction experiments in male and female Wistar rats with long-term (50, 100 and 300 mg/kg p.o. daily for 28 days) and short-term administration (300 mg/kg once and 100 mg/kg daily for 4 days). The increase in total cytochrome P-450 did not exceed the fa...

journal_title：Toxicology letters

authors： von Meyerinck L,Hufnagel B,Schmoldt A,Benthe HF

更新日期：1990-04-01 00:00:00

abstract：:Ochratoxin A (OTA) is one of the most frequent mycotoxins detected in human blood worldwide. Apart from its well known nephrotoxicity, OTA-induced teratogenicity and carcinogenicity proven in animals are potential effects also in humans. Pregnant women have been exposed to this food contaminant via dietary exposure in...

journal_title：Toxicology letters

authors： Woo CS,Partanen H,Myllynen P,Vähäkangas K,El-Nezami H

更新日期：2012-01-05 00:00:00

abstract：:Nonylphenol (NP) is a representative endocrine disruptor that has an adverse effect on male reproduction and posses direct hazard to Sertoli cells, but the mechanism remains incompletely elucidated. In the present study, based on the structural comparability and high affinity between NP and membrane phospholipid molec...

journal_title：Toxicology letters

authors： Gong Y,Pan X,Huang Y,Gao Z,Yu H,Han X

更新日期：2008-12-15 00:00:00

abstract：:Upon entering the body, nerve agents can bind active amino acid residues to form phosphonylated adducts. Tabun derivatives (O-alkyl-N,N-dialkyl phosphoroamidocyanidates) have strikingly different structural features from other G-series nerve agents, such as sarin and soman. Here, we investigate the binding mechanism f...

journal_title：Toxicology letters

authors： Fu F,Liu H,Gao R,Zhao P,Lu X,Zhang R,Wang L,Wang H,Pei C

更新日期：2020-03-15 00:00:00

abstract：:Oral doses of the new cephalosporin cefepime administered to rats for 14 days (40 mg/kg/day) did not affect the activities of the hepatic drug metabolising enzymes measured. By contrast there were highly statistically significant increases in all measured parameters in rats treated with phenobarbitone (80 mg/kg/day), ...

journal_title：Toxicology letters

authors： Jordan MC,Waller AR,Chasseaud LF,Barbhaiya RH

更新日期：1994-03-01 00:00:00

abstract：:We have analysed liver angiosarcomas from individuals having been occupationally exposed to vinyl chloride (VC) to identify, in cancer-related genes, lesions which could be VC-specific. Two genetic alterations have been identified: the first one is a GGC --> GAT (Gly --> Asp, Asp13p21) mutation at codon 13 in the Ki-r...

journal_title：Toxicology letters

authors： Marion MJ

更新日期：1998-12-28 00:00:00

abstract：:Elevated urinary trehalase activity was observed in the inhabitants of the Jinzu River basin. Urinary trehalase activity was correlated with other urinalysis components, such as beta 2-microglobulin, glucose, amino nitrogen, and cadmium, of which a high level was observed in cadmium-polluted areas as compared with the...

journal_title：Toxicology letters

authors： Nakano M,Aoshima K,Katoh T,Teranishi H,Kasuya M

更新日期：1986-12-01 00:00:00

abstract：:The deposition of excess or abnormal collagen characteristic of pulmonary fibrosis can disrupt gas exchange resulting in severe respiratory impairment. There currently are no effective pharmacologic agents available that inhibit the fibrotic process. Pirfenidone (5-methyl-1-phenyl-2-(1H)-pyridone) is an investigationa...

journal_title：Toxicology letters

authors： Kehrer JP,Margolin SB

更新日期：1997-02-07 00:00:00

abstract：:Furan, a potential human carcinogen, is formed during heat-treatment of food. Previous studies of the genotoxicity of furan have given disparate results. Hence, there is a need for complementary data to clarify the mechanism behind the carcinogenicity of furan. In this study, we have used the flow cytometer-based micr...

journal_title：Toxicology letters

authors： Durling LJ,Svensson K,Abramsson-Zetterberg L

更新日期：2007-02-28 00:00:00

abstract：:A teratological test was carried out on triphenyltin acetate (TPTA) used as a fungicide and antifouling agent. Pregnant Wistar rats were treated orally with TPTA at dose levels of 0, 1.5, 3.0, 6.0, 9.0 and 12.0 mg/kg/d during days 7-17 of gestation. Cesarean sections were performed on day 20 of gestation. In the pregn...

journal_title：Toxicology letters

authors： Noda T,Morita S,Yamano T,Shimizu M,Yamada A

更新日期：1991-04-01 00:00:00

abstract：:Sulfur mustard (SM) is a chemical warfare agent causing blistering, inflammation and ulceration of the skin. Thiol compounds such as glutathione (GSH) and N-acetylcysteine (NAC) have been suggested as potential antidotes. We investigated SM toxicity in a human keratinocyte cell line (HaCaT) and used GSH and NAC to cou...

journal_title：Toxicology letters

authors： Balszuweit F,Menacher G,Schmidt A,Kehe K,Popp T,Worek F,Thiermann H,Steinritz D

更新日期：2016-02-26 00:00:00

abstract：:The toxicity of benz (e) acephenanthrylene (BeA) has been studied earlier with regard to the carcinogenicity of its metabolites, but its phototogenotoxicity is not well understood. Present study aimed to analyze the photodynamic response of BeA in human skin cell line (A375) under ambient environmental intensity of UV...

journal_title：Toxicology letters

authors： Ali D,Ray RS,Hans RK

更新日期：2010-11-30 00:00:00

abstract：:Conversion of hepatic stellate cells (HSCs) into hepatic myofibroblasts is a necessary event during the development of liver fibrosis. DNA methyltransferase 1 (DNMT1), which catalyzes DNA methylation and subsequently leads to the transcriptional repression of profibrotic genes, is selectively induced in myofibroblasts...

journal_title：Toxicology letters

authors： Bian EB,Huang C,Wang H,Chen XX,Zhang L,Lv XW,Li J

更新日期：2014-01-13 00:00:00

abstract：:Male C57B1/6N mice, 8-10 weeks old were given a single oral dose of 0, 1.0 or 3.0 mg/kg body weight of trimethyltin hydroxide (TMT). Levels of ornithine decarboxylase (ODC) activity were measured in several brain areas, 1, 2 and 7 days later. The lower dose of TMT produced a decrease of ODC in the caudate nucleus and ...

journal_title：Toxicology letters

authors： Ali SF,Newport GD,Slikker W Jr,Bondy SC

更新日期：1987-03-01 00:00:00

abstract：:In the olfactory epithelium the primary olfactory neurons are in contact with the environment in the nasal cavity and they are also connected to the olfactory bulbs of the brain. These neurons may therefore provide a pathway by which foreign materials may reach the brain. Inhalation of cobalt-containing dust or fumes ...

journal_title：Toxicology letters

authors： Persson E,Henriksson J,Tjälve H

更新日期：2003-11-01 00:00:00

abstract：:Although CSL box jellyfish antivenom (AV) remains the primary treatment for Chironex fleckeri envenoming, there has been considerable debate regarding its clinical effectiveness. Animal studies have shown that AV is largely ineffective in preventing C. fleckeri-induced cardiovascular collapse. This study examined the ...

journal_title：Toxicology letters

authors： Winter KL,Isbister GK,Jacoby T,Seymour JE,Hodgson WC

更新日期：2009-06-01 00:00:00

abstract：:In recent years, interesterified fat (IF) has been used to replace hydrogenated vegetable fat (HVF), rich in trans isomers, being found in processed foods. Studies involving IF have shown deleterious influences on the metabolic system, similarly to HVF, whereas no studies regarding its influence on the central nervous...

journal_title：Toxicology letters

authors： D'avila LF,Dias VT,Vey LT,Milanesi LH,Roversi K,Emanuelli T,Bürger ME,Trevizol F,Maurer HL

更新日期：2017-07-05 00:00:00

abstract：:cis-Diamminedichloroplatinum(II) (cisplatin) is one of the most effective antitumor agents currently available for cancer chemotherapy. Unfortunately, its clinical use is severely limited by its dose-dependent nephrotoxicity. Recently, it has been reported that this nephrotoxicity is associated with an increase in lip...

journal_title：Toxicology letters

authors： Sadzuka Y,Shoji T,Takino Y

更新日期：1991-07-01 00:00:00

abstract：:Cellular uptake and cytotoxicity of chenodeoxycholic acid, delivered free or encapsulated in liposomes, were compared in isolated rat hepatocytes. As quantified by leakage of cytoplasmic and lysosomal enzymes into the medium, cells exposed to free chenodeoxycholic acid displayed a dose-dependent cytotoxic response. Ce...

journal_title：Toxicology letters

authors： Salhab AS,Stacey NH,Dujovne CA

更新日期：1984-04-01 00:00:00

abstract：:The effect of salicylate, the active metabolite of aspirin (acetyl salicylic acid) in the presence of Ca2+ and phosphate on mitochondrial permeability transition (MPT) was studied. MPT is often associated with opening of a Ca2+ -induced pore. The opening of this pore leads to swelling, loss of mitochondrial membrane p...

journal_title：Toxicology letters

authors： Al-Nasser IA

更新日期：1999-03-08 00:00:00

abstract：:In order to study the effect of arsenic on DNA damage, Sprague-Dawley rats were dosed with sodium arsenite (10 mg/kg) with or without 800 microg of benzo(a)pyrene (BP) by intramammilary injection. The animals were sacrificed on day 1, 3, 5, 10 and 27 and the mammary gland tissues were collected for DNA adduct measurem...

journal_title：Toxicology letters

authors： Tran HP,Prakash AS,Barnard R,Chiswell B,Ng JC

更新日期：2002-07-07 00:00:00

abstract：:This paper compares two methods for global optimization of physiologically based toxicokinetic models: Monte Carlo optimization, which searches randomly for the optimum; and the simplex method, which updates systematically an array of parameter values. Two measures of goodness-of-fit are also contrasted: criterion fun...

journal_title：Toxicology letters

authors： Woodruff TJ,Bois FY

更新日期：1993-08-01 00:00:00

abstract：:Metallothionein (MT) is inducible by various stimuli such as metals and physiological stress. Although elevated MT expression in certain type of tumors has been reported, there are few data available on the roles of MT in tumor formation. In this study, we immunohistochemically examined MT expression in gluthathione S...

journal_title：Toxicology letters

authors： Sawaki M,Enomoto K,Hattori A,Tsuzuki N,Sawada N,Mori M

更新日期：1999-07-30 00:00:00

abstract：:The behavioral effects of concurrent maternal exposure to restraint stress and perfluorooctane sulfonate (PFOS) were assessed in the offspring of mice at 3 months of age. Plug positive females were divided into two groups. Animals were given by gavage 0 and 6mg PFOS/kg/day on gestation days 12-18. One-half of the anim...

journal_title：Toxicology letters

authors： Fuentes S,Colomina MT,Vicens P,Domingo JL

更新日期：2007-07-10 00:00:00

abstract：:Alkyl hydroperoxide reductase 1 (Ahp1p) is a thioredoxin peroxidase of the peroxiredoxin family expressed by Saccharomyces cerevisiae. Recently, disruption of the AHP1 gene has shown that the gene is not essential for yeast growth on glucose medium but revealed a high sensitivity of null mutants to organic peroxides, ...

journal_title：Toxicology letters

authors： Nguyên-nhu NT,Knoops B

更新日期：2002-10-05 00:00:00

abstract：:Spontaneous neoplasms in untreated control CD-1 mice (725 males and 725 females) used in carcinogenicity studies were evaluated and tabulated. The most common neoplasms in male mice were alveolar-bronchiolar adenomas (19.3%) followed by hepatocellular adenomas (11.0%), lymphoreticular neoplasms (6.8%), hepatocellular ...

journal_title：Toxicology letters

authors： Chandra M,Frith CH

更新日期：1992-06-01 00:00:00

abstract：:Olefinic hydrocarbons are metabolized in vivo by cytochrome P450-dependent monooxygenases to the corresponding epoxides. The maximum in vivo metabolic rate, which is an important toxicokinetic parameter, has been used to define the apparent rate constant (kapp) describing in vivo metabolic reactivity of alkenes. To de...

journal_title：Toxicology letters

authors： Csandy GA,Laib RJ,Filser JG

更新日期：1995-01-01 00:00:00

abstract：:The lithocholic acid-sensitive mutant cells were isolated from CHO-9 cells mutagenized with ethylmethane sulfonate, through clonal selection on 96-well dishes. The isolated mutant cells (LSJ-11) were 3-fold more sensitive than controls in the survival to lithocholic acid and were also sensitive to other bile acids suc...

journal_title：Toxicology letters

authors： Kaneko M,Kodama M,Inoue F,Horikoshi J

更新日期：1993-03-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and often carcinogenic contaminants released into the environment during natural and anthropogenic combustion processes. Benzo[a]pyrene (B[a]P) is the prototypical carcinogenic PAH, and dibenzo[def,p]chrysene (DBC) is a less prevalent, but highly potent transplace...

journal_title：Toxicology letters

authors： Crowell SR,Hanson-Drury S,Williams DE,Corley RA

更新日期：2014-07-03 00:00:00

abstract：:Checkpoint kinase 1 (Chk1) is required for both intra-S phase and G2/M checkpoints in cell cycle, and plays critical roles in maintaining genomic stability and transducing DNA damage response. Chk1 deficiency has been shown to inhibit T-cell differentiation and resulted in severe anemia in a Chk1 heterozygous mouse mo...

journal_title：Toxicology letters

authors： Hu W,Zong Q,John-Baptiste A,Jessen B

更新日期：2011-07-28 00:00:00