Ozone-induced human respiratory dysfunction and disease.


:Exercising volunteers exposed in chambers to as little as 80 ppb O3 for several hours exhibit impaired lung function and irritative lower airway symptoms. Comparable changes occur among children and young adults exposed to summer smog containing O3. Intensity of the response is reproducible but varies widely among individuals. The (reversible) decrements in vital capacity are due to involuntary inhibition of deep inspiration probably mediated by nociceptive bronchial C-fibers that may be stimulated by local prostaglandin release, and can be modulated by appropriate pharmacologic agents. A second characteristic response to low O3 levels is mucosal neutrophilic inflammation probably mediated by phospholipid-derived products and by epithelial cell-derived chemokines and cytokines, but poorly correlated with lung function changes. Fluctuations in ambient O3 levels are associated with acute respiratory health effects in exposed populations but concomitant acid aerosol pollution is an important confounder. Whether irreversible impairment of lung function occurs among residents of chronically high ozone-pollution areas is debated.


Toxicol Lett


Toxicology letters


Bromberg PA,Koren HS




Has Abstract


1995-12-01 00:00:00












  • Activation-induced cell death signalling in CD4+ T cells by staphylococcal enterotoxin A.

    abstract::Staphylococcal enterotoxin A (SEA) is a potent stimulator of CD4+ and CD8+ T cells, the immunotoxic action of which remains unclear. We investigated the in vitro effects of SEA on freshly isolated human peripheral blood lymphocytes depleted of CD8+ T cells. Proliferation and flow cytometry analysis indicated that SEA ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Porichis F,Morou A,Baritaki S,Spandidos DA,Krambovitis E

    更新日期:2008-01-04 00:00:00

  • The uncoupling effect of flavoglaucin, a quinol pigment from Aspergillus chevalieri (Mangin), on mitochondrial respiration.

    abstract::The effects of flavoglaucin from Aspergillus chevalieri (Mangin) Thom et Church on mitochondrial reactions have been investigated to obtain insight into the mode of actions on biomembranes by means of isolated rat liver mitochondria. It was found that flavoglaucin exhibited a strong uncoupling effect on oxidative phos...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kawai K,Mori H,Kitamura J

    更新日期:1983-12-01 00:00:00

  • Effect of the cephalosporin cefepime on hepatic drug metabolising enzyme activity in rats.

    abstract::Oral doses of the new cephalosporin cefepime administered to rats for 14 days (40 mg/kg/day) did not affect the activities of the hepatic drug metabolising enzymes measured. By contrast there were highly statistically significant increases in all measured parameters in rats treated with phenobarbitone (80 mg/kg/day), ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Jordan MC,Waller AR,Chasseaud LF,Barbhaiya RH

    更新日期:1994-03-01 00:00:00

  • Gene expression profile and cytotoxicity of human bronchial epithelial cells exposed to crotonaldehyde.

    abstract::Crotonaldehyde is an environment pollutant and lipid peroxidation product. Crotonaldehyde produces adverse effects to humans and serves as a risk factor for human pulmonary diseases. Like acrolein and 4-hydroxynonenal, crotonaldehyde seems likely to alter many cell signaling cascades, including inflammatory responses....

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Liu XY,Yang ZH,Pan XJ,Zhu MX,Xie JP

    更新日期:2010-08-16 00:00:00

  • Poly-l-aspartic acid protects cultured human proximal tubule cells against aminoglycoside-induced electrophysiological alterations.

    abstract::Cultured human proximal tubule cell monolayers maintained on permeable supports were treated simultaneously with the aminoglycoside antibiotic, gentamicin, and poly-L-aspartic acid (PAA), an inhibitor of aminoglycoside nephrotoxicity. Following 4 days of exposure, cell monolayers were placed into Ussing chambers to al...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Todd JH,Hottendorf GH

    更新日期:1997-02-07 00:00:00

  • Initiation/promotion assay for chemical carcinogens in rat liver.

    abstract::A short-term initiation/promotion bioassay has been developed in rat liver using putative preneoplastic foci as the endpoint for the detection of chemical carcinogens. The two protocols of the bioassay used in this study were varied according to the time 2/3 partial hepatectomy was performed in relation to when the in...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Herren SL,Pereira MA,Britt AL,Khoury MK

    更新日期:1982-07-01 00:00:00

  • Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast.

    abstract::The phthalates di(2-ethylhexyl)phthalate (DEHP) and di-n-butyl phthalate (DBP) are environmental contaminants with significant human exposures. Both compounds are known reproductive toxins in rodents and DEHP also induces rodent hepatocarcinogenesis in a process believed to be mediated via the peroxisome proliferator-...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Venkata NG,Robinson JA,Cabot PJ,Davis B,Monteith GR,Roberts-Thomson SJ

    更新日期:2006-06-01 00:00:00

  • Salicylate-induced kidney mitochondrial permeability transition is prevented by cyclosporin A.

    abstract::The effect of salicylate, the active metabolite of aspirin (acetyl salicylic acid) in the presence of Ca2+ and phosphate on mitochondrial permeability transition (MPT) was studied. MPT is often associated with opening of a Ca2+ -induced pore. The opening of this pore leads to swelling, loss of mitochondrial membrane p...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Al-Nasser IA

    更新日期:1999-03-08 00:00:00

  • Molecular epidemiology and human risk monitoring.

    abstract::Molecular epidemiologic research involves the identification of relations between previous exposure to some putative causative agent and subsequent biological effects in a cluster of individuals in populations. There is intensive current research in the field of molecular epidemiology, and this research has a direct i...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Groopman JD,Kensler TW,Links JM

    更新日期:1995-12-01 00:00:00

  • Evaluation of selective and non-selective cyclooxygenase inhibitors on sulfur mustard-induced pro-inflammatory cytokine formation in normal human epidermal keratinocytes.

    abstract::Sulfur mustard (SM) is a highly toxic chemical warfare agent, which produces blisters after skin contact. Treatment of SM-induced adverse health effects, such as cutaneous blistering, ulceration, and inflammation remains a challenging task. Antidotes or specific therapeutic measures are lacking. Some drugs (e.g. cyclo...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Wagner S,Lang S,Popp T,Schmidt A,Thiermann H,Steinritz D,Kehe K

    更新日期:2019-09-15 00:00:00

  • Hepatic and muscle injuries in mice treated with heptachlor.

    abstract::Heptachlor is a major component of the insecticide, chlordane. It is a health hazard but is still in use in some countries of Southeast Asia. To elucidate the toxicity of heptachlor its effects on mice after oral and intraperitoneal administration were studied. A 3-day group, 92-day group and 180-day group were given ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Izushi F,Ogata M

    更新日期:1990-11-01 00:00:00

  • Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells.

    abstract::Kahweol, the coffee-specific diterpene, has been reported to have anti-carcinogenic properties. Animal data support such a chemopreventive effect of coffee. However, the precise underlying protective mechanisms are poorly understood. In this study, the apoptotic effect of kahweol in human lung adenocarcinoma A549 cell...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kim HG,Hwang YP,Jeong HG

    更新日期:2009-05-22 00:00:00

  • In vivo and in vitro effect of chelating agents on drug metabolizing enzymes of the rat.

    abstract::Rats given calcium disodium ethylenediaminetetraacetic acid (CaNa2EDTA), diethylenetriaminepentaacetic acid (DTPA), dimercaprol, p-aminosalicylic acid (PAS), or d-penicillamine (penicillamine) i.p. for 7 successive days showed a significant decrease in the activity of hepatic microsomal benzphetamine N-demethylase. Th...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Dalvi RR,McGowan C,Ademoyero A

    更新日期:1980-06-01 00:00:00

  • Doxorubicin can penetrate nitrile gloves and induces apoptosis in keratinocytes cell lines.

    abstract::Doxorubicin (DOXO) is an anthracycline antibiotic which is used in the treatment of human malignancies such as leukemia, lymphoma and a number of solid tumors, particularly breast cancer. Anthracyclines have been reported to contaminate chemotherapy workstation surfaces as well as other workplaces surfaces. The occupa...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Boccellino M,Pedata P,Castiglia L,La Porta R,Pieri M,Quagliuolo L,Acampora A,Sannolo N,Miraglia N

    更新日期:2010-08-16 00:00:00

  • Modifying effects of prepubertal exposure to potassium perchlorate and tetrabromobisphenol A on susceptibility to N-bis(2-hydroxypropyl)nitrosamine- and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in rats.

    abstract::Early life exposure to certain kinds of chemicals is of concern because of a possible increase in cancer risk, but relevant data are limited. In the present experiment, modifying effects of prepubertal administration of potassium perchlorate (KClO(4)) and tetrabromobisphenol A (TBBPA) on susceptibility to multi-organ ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Imai T,Takami S,Cho YM,Hirose M,Nishikawa A

    更新日期:2009-03-28 00:00:00

  • Antioxidant property of metallothionein in fasted mice.

    abstract::Metallothionein (MT) is a low-molecular-weight and sulfur-rich protein that is induced by not only heavy metals but also physiological stresses such as fasting and restraint stresses. Although MT plays a role as a radical scavenger and a regulator of metabolism of metals, the biological function of MT induced by fasti...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kondoh M,Kamada K,Kuronaga M,Higashimoto M,Takiguchi M,Watanabe Y,Sato M

    更新日期:2003-08-28 00:00:00

  • General 4-week toxicity study with EMS in the rat.

    abstract::In this subacute toxicity study, ethyl methanesulfonate (EMS) was administered daily by oral gavage to SPF-bred Wistar rats of both sexes at dose levels of 20, 60 and 180/120 mg/kg body weight (bw)/day for a period of 28 days (for 19 days in the high-dose group). A control group was treated similarly with the vehicle,...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Pfister T,Eichinger-Chapelon A

    更新日期:2009-11-12 00:00:00

  • Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways.

    abstract::In addition to evidence that inhalation of ambient particulate matter (PM) can increase cardiopulmonary morbidity and mortality, the brain may also constitute a site adversely effected by the environmental presence of airborne particulate matter. We have examined the association between exposure to PM and adverse CNS ...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kleinman MT,Araujo JA,Nel A,Sioutas C,Campbell A,Cong PQ,Li H,Bondy SC

    更新日期:2008-05-05 00:00:00

  • Hepatic cytochrome P450 and flavin-containing monooxygenase in male Nts:Mini rat, a transgenic rat carrying antisense RNA transgene for rat growth hormone.

    abstract::We investigated the characteristics of hepatic cytochrome P450s and flavin-containing monooxygenase 1 (FMO1) in male Nts:Mini rats, a Wistar/Jcl-derived transgenic rat strain showing less plasma GH concentration than the parental strain. The total hepatic P450 contents of Mini rats were significantly reduced. A suppre...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Tani Y,Yamamoto H,Kawaji A,Mizuno H,Fukushige J,Hosokawa T,Doi K

    更新日期:1999-06-01 00:00:00

  • Reduction of phosphoinositides and diacylglycerol levels in repeatedly dibutyltin-dilaurate-treated rat brain.

    abstract::Oral administration of a single dose of dibutyltin dilaurate (DBTL, 80 mg/kg body wt.), 2 or 24 h after treatment, caused no significant change in the levels of diacylglycerol and phosphoinositides in rat cerebrum (forebrain), whereas daily administration of DBTL (40 or 80 mg/kg body wt.) for 3 days (24 h after the fi...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Subramoniam A,Husain R,Seth PK

    更新日期:1991-08-01 00:00:00

  • Scoring multiple toxicological endpoints using a toxicogenomic database.

    abstract::As information regarding microarray data sets and toxicogenomic biomarkers grows rapidly, the process of analyzing data and interpreting the results is increasingly complicated. To facilitate data analysis, a simple expression ratio-based scoring method called the TGP1 score was previously proposed [Kiyosawa, N., Shiw...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kiyosawa N,Ando Y,Watanabe K,Niino N,Manabe S,Yamoto T

    更新日期:2009-07-24 00:00:00

  • Study on dermal toxicity and urinary metabolites of the new insect repellent N,N-diethylphenylacetamide in rabbits.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Rao SS,Agarwal MK,Rao KM,Swamy RV

    更新日期:1989-01-01 00:00:00

  • Inhibition of glutathione S-transferase P type-positive foci development by linolic acid hydroperoxides and their secondary oxidative products in a rat in vivo mid-term test for liver carcinogens.

    abstract::The effects of linolic acid hydroperoxides (product A) and secondary oxidative products of product A (product B), were examined in an in vivo mid-term test for hepatocarcinogens or hepatopromoters in rats. The number of placental type of glutathione S-transferase (GST-P)-positive foci of the liver was significantly re...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Hirose M,Thamavit W,Asamoto M,Osawa T,Ito N

    更新日期:1986-07-01 00:00:00

  • Vinylphenylmercapturic acids in human urine as biomarkers of styrene ring oxidation.

    abstract::New metabolites of styrene, three isomeric vinylphenylmercapturic acids (2-, 3-, and 4-VPMA), were recently identified by LC-ESI-MS in the urine of mice. In this study, 4-VPMA together with traces of 2- and 3-VPMA were found also in the urine of hand-lamination workers, which were exposed to styrene vapours at concent...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Linhart I,Mráz J,Dabrowská L,Mališ M,Krouželka J,Kořínek M

    更新日期:2012-09-03 00:00:00

  • Magnetic nanogels as dual triggered anticancer drug delivery: Toxicity evaluation on isolated rat liver mitochondria.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Sadighian S,Rostamizadeh K,Hosseini MJ,Hamidi M,Hosseini-Monfared H

    更新日期:2017-08-15 00:00:00

  • Elimination of adverse effects of ethoxyquin (EQ) by methionine hydroxy analog (MHA). Protective effects of EQ and MHA for bitterweed poisoning in sheep.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Kim HL,Herrig BW,Anderson AC,Jones LP,Calhoun MC

    更新日期:1983-04-01 00:00:00

  • EMP-induced alterations of tight junction protein expression and disruption of the blood-brain barrier.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ding GR,Qiu LB,Wang XW,Li KC,Zhou YC,Zhou Y,Zhang J,Zhou JX,Li YR,Guo GZ

    更新日期:2010-07-15 00:00:00

  • Genotoxicity induced in cultured Chinese hamster cells exposed to natural or synthetic crude oils and near ultraviolet light.

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    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Strniste GF,Bingham JM,Okinaka RT,Chen DJ

    更新日期:1982-10-01 00:00:00

  • Environmental contaminants and human health in the Arctic.

    abstract::Monitoring of human exposure to persistent organic pollutants POPs and heavy metals have taken place since 1994 in a circumpolar study conducted under the Arctic monitoring and assessment programme (AMAP). The study has confirmed that Arctic populations relying on marine food (Inuit) have an exposure level of POPs and...

    journal_title:Toxicology letters

    pub_type: 杂志文章,评审


    authors: Hansen JC

    更新日期:2000-03-15 00:00:00

  • Suppression of microsomal cytochrome P450-dependent monooxygenases and mitochondrial oxidative phosphorylation by fullerenol, a polyhydroxylated fullerene C60.

    abstract::The acute toxicity of fullerenol-1 was determined using mice pretreated intraperitoneally (i.p.) with polyhydroxylated C60 derivatives. The LD50 value of fullerenol-1 was estimated to be 1.2 g/kg. Pretreatments with 0.5 and 1.0 g/kg fullerenol-1 decreased cytochromes P450 and b5 contents, and NADPH-cytochrome P450 red...

    journal_title:Toxicology letters

    pub_type: 杂志文章


    authors: Ueng TH,Kang JJ,Wang HW,Cheng YW,Chiang LY

    更新日期:1997-09-19 00:00:00