The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in Caco-2 cells.

abstract：:Evaluating myelotoxicity is essential for ensuring the safety of novel drugs before they are approved for clinical applications. Although in vivo prediction of the maximum tolerated doses (MTDs) of anticancer drugs is usually performed in rodents, the results are not always applicable to clinical treatment because dru...

journal_title：Toxicology letters

authors： Ito R,Nagai D,Igo N,Okuda Y,Sekine K,Ichimura E,Katano I,Mizushima T,Goto M,Ohnishi Y,Ito M,Okamoto K

更新日期：2017-11-05 00:00:00

abstract：:To help minimize errors and confusion in the scientific literature, a few principles can be followed. The original intent and hypothesis of each study should be made clear, and deviations from the initial purpose should be stated. The hypothesis-testing portions of the research need to be clearly differentiated from t...

journal_title：Toxicology letters

authors： Maurissen JP

更新日期：1995-12-01 00:00:00

abstract：:In the present study experiments are described, which indicate that the exposure of normal human skin fibroblasts (HSFs) to a low-frequency electromagnetic field of 20 Hz and 7-8 mT does induce terminal differentiation within 14 days of daily exposure of 12 h. As demonstrated by the analysis of the expression level of...

journal_title：Toxicology letters

authors： Löschinger M,Thumm S,Hämmerle H,Rodemann HP

更新日期：1998-08-01 00:00:00

abstract：:The effect of copper (Cu) deficiency on antioxidant status of liver and heart and its effect on adriamycin toxicity was assessed. Weanling rats were fed Cu-adequate (+Cu) and Cu-deficient (-Cu) diets for 3 weeks and then injected intraperitoneally once with saline or adriamycin (8 mg/kg). All -Cu rats had increased he...

journal_title：Toxicology letters

authors： Fischer J,Johnson MA,Tackett RL

更新日期：1991-07-01 00:00:00

abstract：:The fast growing applications of ZnO nanoparticles (NPs) in food sector and other fields enhance the exposure possibility of human beings to ZnO NPs including via oral administration route. Although the oral toxicity of ZnO NPs has been studied, most of the research was performed on the normal animal models. Therefore...

journal_title：Toxicology letters

authors： Du LJ,Xiang K,Liu JH,Song ZM,Liu Y,Cao A,Wang H

更新日期：2018-10-01 00:00:00

abstract：:The polychlorinated biphenyls (PCBs) have been demonstrated to be inducers of hepatic microsomal enzymes and some of their effects such as hormonal imbalance, and alteration of lipid and porphyrin metabolism could be ascribed to this mechanism. For this reason, the urinary excretion of D-glucaric acid (DGA), an indire...

journal_title：Toxicology letters

authors： Apostoli P,Mangili A,Carasi S,Manno M

更新日期：2003-09-15 00:00:00

abstract：:Pulmonary fibrosis is a serious adverse effect of radiotherapy for thoracic tumor, which is believed to be a process that is tightly regulated by the phenotype of the developing Th response after radiation. Here, we will investigate whether CpG-oligodeoxynucleotides (ODN) prevent radiation-induced pulmonary fibrosis b...

journal_title：Toxicology letters

authors： Zhang C,Zhao H,Li BL,Fu-Gao,Liu H,Cai JM,Zheng M

更新日期：2018-08-01 00:00:00

abstract：:Chemical-peptide conjugation is the molecular initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatography/ultraviolet (HPLC/UV) detection method to quantify chemical-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two sy...

journal_title：Toxicology letters

authors： Wei Z,Fang Y,Gosztyla ML,Li AJ,Huang W,LeClair CA,Simeonov A,Tao D,Xia M

更新日期：2021-03-01 00:00:00

abstract：:In Europe and the USA the prevalence of certain forms of allergic disease is rising; an increase that can not be reconciled simply on the basis of changes in diagnostic fashion. The changes observed have been too rapid to be explained by alterations in the gene pool and, as a consequence, there has been a growing inte...

journal_title：Toxicology letters

authors： Kimber I

更新日期：1998-12-28 00:00:00

abstract：:To test the hypothesis that 3-7 ring polycyclic aromatic hydrocarbons (PAHs) are responsible for the prenatal developmental toxicity (PDT) as observed with some petroleum substances (PS), the present study evaluates the PDT potency of DMSO-extracts of 7 heavy fuel oils (HFO), varying in their PAH content, and 1 highly...

journal_title：Toxicology letters

authors： Kamelia L,de Haan L,Ketelslegers HB,Rietjens IMCM,Boogaard PJ

更新日期：2019-10-15 00:00:00

abstract：:As a recreational drug of abuse and an injectable anesthetic, ketamine has been shown to cause cognitive dysfunction and induce psychotic states. Although the specific mechanism is still unclear, it may be linked to synaptic receptors, including the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor...

journal_title：Toxicology letters

authors： Li Y,Ding R,Ren X,Wen G,Dong Z,Yao H,Tan Y,Yu H,Wang X,Zhan X,Yao J,Lu Y,Zhang G,Wu X

更新日期：2019-10-15 00:00:00

abstract：:Gastrointestinal tract is one of the main targets of cadmium (Cd), an important food and drinking water contaminant. In the present study, the effect of subchronic (30 days) oral (in water) intake of 5ppm and 50ppm of cadmium on immune responses in the gut was examined in rats. Cadmium consumption resulted in reductio...

journal_title：Toxicology letters

authors： Ninkov M,Popov Aleksandrov A,Demenesku J,Mirkov I,Mileusnic D,Petrovic A,Grigorov I,Zolotarevski L,Tolinacki M,Kataranovski D,Brceski I,Kataranovski M

更新日期：2015-09-02 00:00:00

abstract：:The genotoxicity of polycyclic aromatic hydrocarbons (PAHs) and nitrated PAHs may be influenced by the interaction of the compounds. In this study, our data showed that benzo[a]pyrene (BaP)-DNA adduct levels were decreased in a dose-dependent manner when the human hepatoma cell line HepG2 simultaneously treated with B...

journal_title：Toxicology letters

authors： Cherng SH,Hsu SL,Yang JL,Yu CT,Lee H

更新日期：2006-03-01 00:00:00

abstract：:Identification of genetic polymorphisms responsible for reduced DNA repair capacity may allow better cancer prevention. We examined whether variations in genes involved in base-excision (hOGG1, XRCC1) and double strand break (XRCC3) DNA repair contribute to inter-individual differences in genotoxic effects induced in ...

journal_title：Toxicology letters

authors： Mateuca R,Aka PV,De Boeck M,Hauspie R,Kirsch-Volders M,Lison D

更新日期：2005-04-10 00:00:00

abstract：:Mouse neuroblastoma cells exposed to 2.5 and 5.0 microM methylmercury for 24 h appeared rounded with the loss of processes. Immunohistochemical staining directed against beta-tubulin revealed severe alterations in microtubular architecture. Non-membrane-bound condensation product was visualized ultrastructurally in th...

journal_title：Toxicology letters

authors： Kromidas L,Trombetta LD,Jamall IS

更新日期：1990-03-01 00:00:00

abstract：:Intraperitoneal injection of the iron-complex, ferric-nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage associated with oxidative damage in vivo. Fe-NTA induced a time-dependent decrease of several polyunsaturated fatty acids (PUFA), together with increased conjugated diene values and decreased cellula...

journal_title：Toxicology letters

authors： Deiana M,Aruoma OI,Rosa A,Crobu V,Casu V,Piga R,Dessi MA

更新日期：2001-09-15 00:00:00

abstract：:This work studies the potential subacute toxicological effects of the aqueous extract of Baccharis genistelloides (AEBg) and demonstrates a new anti-arthritic therapeutic effect. The treatment of the collagen-induced arthritis (CIA) group with 4.2 mg/kg AEBg induced an important decrease (75%) in CIA severity in all a...

journal_title：Toxicology letters

authors： Coelho MG,Reis PA,Gava VB,Marques PR,Gayer CR,Laranja GA,Felzenswalb I,Sabino KC

更新日期：2004-12-01 00:00:00

abstract：:In this study, the action of 3-nitropropionic acid (3-NP) on the parameters of the cortical and peripheral evoked potentials was investigated in rats in different administration schemes (20 mg/kg i.p. during recording or 24 h before, and 5x 15 mg/kg daily 28 days before recording) to elucidate some neurophysiological ...

journal_title：Toxicology letters

authors： Szabó A,Papp A,Nagymajtényi L,Vezér T

更新日期：2006-01-25 00:00:00

abstract：:An atomic absorption spectrophotometric (AAS) method was successfully applied to analysis of urine for arsenic (As) as a measure of biological monitoring of occupational exposure to As in Vietnam. The application of the method to urine samples from 75 non-exposed control urbanites (after 2-day abstinence from sea food...

journal_title：Toxicology letters

authors： Dang TM,Tran QT,Vu KV

更新日期：1999-09-05 00:00:00

abstract：:Intraperitoneal (i.p.) and intravenous (i.v.) injection of 44Ti in a chloride solution into mice produced no detectable translocation in body fluids. There was no obvious interorgan exchange up to 16 days after injection. The whole body biological retention half-lives had a mean of 642 days for both routes, another in...

journal_title：Toxicology letters

authors： Thomas RG,Archuleta RF

更新日期：1980-07-01 00:00:00

abstract：:There is potential for oral exposure of humans to styrene (ST) such as from migration of residual levels in polystyrene food containers. After absorption, ST is metabolised to styrene-7,8-oxide (SO), an alkylating epoxide. Hence, a comparison of blood burdens of SO resulting from oral exposures to ST was made with SO ...

journal_title：Toxicology letters

authors： Filser JG,Gelbke HP

更新日期：2016-04-15 00:00:00

abstract：:The dose-dependent effects of sodium saccharin on the fertility and the induction of chromosomal translocations in treated mice and their F1 males were examined. C3H X 101 mice were treated with saccharin for 2 successive weeks at doses of 200 and 500 mg/kg of body wt. Data from the fertility study showed that sacchar...

journal_title：Toxicology letters

authors： Pecevski J,Vuksanović L,Savković N,Alavantić D,Radivojević D

更新日期：1983-12-01 00:00:00

abstract：:A detailed characterisation of the biotransformation pathways followed by the chemical of interest is, evidently, of primordial importance to design reliable biomonitoring programs. This short overview discusses some recent studies that are of potential interest for the development of new avenues of research. Four top...

journal_title：Toxicology letters

authors： Lison D

更新日期：1999-09-05 00:00:00

abstract：:In order to study the effect of arsenic on DNA damage, Sprague-Dawley rats were dosed with sodium arsenite (10 mg/kg) with or without 800 microg of benzo(a)pyrene (BP) by intramammilary injection. The animals were sacrificed on day 1, 3, 5, 10 and 27 and the mammary gland tissues were collected for DNA adduct measurem...

journal_title：Toxicology letters

authors： Tran HP,Prakash AS,Barnard R,Chiswell B,Ng JC

更新日期：2002-07-07 00:00:00

abstract：:In August 2003, 44 victims were poisoned by chemical warfare agents (CWAs) leaked from five drums that were excavated at a construction site in Qiqihar, Northeast China. The drums were abandoned by the former Japanese imperial army during World War II and contained a mixture of Sulfur mustard (SM) and Lewisite. We car...

journal_title：Toxicology letters

authors： Isono O,Kituda A,Fujii M,Yoshinaka T,Nakagawa G,Suzuki Y

更新日期：2018-09-01 00:00:00

abstract：:Mercury is the major component of dental amalgam restorative material, which typically has 50% pure elemental mercury. It is also used in some skin creams, and in the manufacturing of plastic, drugs and fungicides. The present study was designed to investigate the toxicity of methyl mercury (MeHg+) on isolated rat hep...

journal_title：Toxicology letters

authors： Ashour H,Abdel-Rahman M,Khodair A

更新日期：1993-07-01 00:00:00

abstract：:Treatment of pregnant C57BL/6N mice with 2,3,7,8-tetrachlorodibenzofuran (TCDF) (0, 250, 500, and 1000 micrograms/kg on gestation day 10 or 0, 10, 30, 50, and 100 micrograms/kg on gestation days 10-13) results in dose-related increases in isolated cleft palates and hydronephrotic kidneys in the offspring. TCDF is tera...

journal_title：Toxicology letters

authors： Weber H,Lamb JC,Harris MW,Moore JA

更新日期：1984-02-01 00:00:00

abstract：:Pregnant CD-1 mice were given 32 mg/kg of 3,4,3',4'-tetrachlorobiphenyl (TCB) or corn oil vehicle, by gavage, on days 10--16 of gestation. At 1 year of age, the offspring were tested for spontaneous motor activity; the mice were then killed and dopamine (DA) levels and specific DA receptor binding were measured in the...

journal_title：Toxicology letters

authors： Agrawal AK,Tilson HA,Bondy SC

更新日期：1981-03-01 00:00:00

abstract：:Transcription factor NF-E2-related factor 2 (NRF2) plays a crucial role in the cellular defense against oxidative/electrophilic stress by up-regulating multiple antioxidant genes. Numerous studies with genetically modified animals have demonstrated that Nrf2 is a sensitivity determining factor upon the exposure to env...

journal_title：Toxicology letters

authors： Jung KA,Choi BH,Nam CW,Song M,Kim ST,Lee JY,Kwak MK

更新日期：2013-03-27 00:00:00

abstract：:The repeated use of the nerve agent sarin against civilians in Syria in 2013 emphasizes the continuing threat by chemical warfare agents. Multiple studies demonstrated a limited efficacy of standard atropine-oxime treatment in nerve agent poisoning and called for the development of alternative and more effective treat...

journal_title：Toxicology letters

authors： Worek F,Thiermann H,Wille T

更新日期：2016-02-26 00:00:00