Abstract：
:Exposure of C57Bl mice to 10 ppm benzene (the current occupational exposure limit) for 6 h/day, 5 days/week causes a progressive depression in the in vitro colony forming ability of one of the erythroid progenitor cells, the colony-forming unit-erythroid (CFU-E). Colony growth of cells from exposed mice was only 5% of control colony growth after 178 days of exposure. Burst-forming-cell growth was depressed to 55% of control growth after 66 days but returned to control growth values at 178 days. In addition, benzene-exposed mice exhibited depressions in the numbers of splenic nucleated red cells and in the numbers of circulating red cells and lymphocytes. These results suggest that low-level exposure to benzene may be hematotoxic.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Baarson KA,Snyder CA,Albert REdoi
10.1016/0378-4274(84)90169-3subject
Has Abstractpub_date
1984-03-01 00:00:00pages
337-42issue
3eissn
0378-4274issn
1879-3169pii
0378-4274(84)90169-3journal_volume
20pub_type
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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更新日期：2014-12-01 00:00:00
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journal_title：Toxicology letters
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更新日期：2001-03-31 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2015.08.002
更新日期：2015-11-04 00:00:00
abstract：:Oxime-based acetylcholinesterase reactivators (briefly oximes) regenerate organophosphate-inactivated acetylcholinesterase and restore its function. Poor blood-brain-barrier passage and fast elimination from blood limit their actual use in treatment of patients exposed to organophosphates. Previous in vitro results im...
journal_title：Toxicology letters
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更新日期：2020-03-01 00:00:00
