Abstract:
:The hepatotoxic effects of the oral administration of a single dose of 50 mg dimethylnitrosamine (DMN)/kg and daily doses of 5 mg and 1 mg/kg, respectively, to cats and lizards were studied by light microscopy. Centrilobular necrosis was the main alteration detected in the liver of cats as in other animal species studied. The lizards, however, appeared unaffected. Morphological changes observed in the liver of these reptiles included haemorrhage, vacuolation of hepatocytes and diffuse nuclear changes; including pyknosis, karyorrhexis and karyolysis. Haemorrhage was also evident in the liver of cats as well as leukocytic infiltration;. including macrophages, lymphocytes and neutrophils. Cats appeared to be more susceptible to DMN poisoning.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Maduagwu EN,Anosa VOdoi
10.1016/0378-4274(81)90172-7subject
Has Abstractpub_date
1981-09-01 00:00:00pages
41-4issue
1eissn
0378-4274issn
1879-3169pii
0378-4274(81)90172-7journal_volume
9pub_type
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journal_title:Toxicology letters
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2020-10-10 00:00:00
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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更新日期:1994-02-15 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(81)90077-1
更新日期:1981-01-01 00:00:00
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journal_title:Toxicology letters
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更新日期:1982-03-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.toxlet.2008.06.003
更新日期:2008-08-15 00:00:00
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更新日期:1995-01-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2018-09-15 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章,评审
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更新日期:2004-04-01 00:00:00
abstract::Deoxynivalenol (DON) is a type B trichothecene mycotoxin that exerts multiple toxic effects on plants, animals and humans. Several reports have shown that DON leads to G2/M cell cycle arrest. However, its molecular mechanism is still unclear. In this study, we showed that DON induced strong G2/M cell cycle arrest in H...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2018.09.012
更新日期:2018-12-15 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2007.09.005
更新日期:2007-12-10 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2007.09.006
更新日期:2008-01-04 00:00:00
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journal_title:Toxicology letters
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更新日期:1995-06-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2011.12.018
更新日期:2012-03-25 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(89)90186-0
更新日期:1989-07-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2013.10.038
更新日期:2014-01-13 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(97)00042-8
更新日期:1997-07-21 00:00:00