Abstract:
:The effects of flavoglaucin from Aspergillus chevalieri (Mangin) Thom et Church on mitochondrial reactions have been investigated to obtain insight into the mode of actions on biomembranes by means of isolated rat liver mitochondria. It was found that flavoglaucin exhibited a strong uncoupling effect on oxidative phosphorylation, enhanced the latent ATPase activity, and elicited a drastic swelling of mitochondria. These reactions led to the exhaustion of ATP in cells, which may be, in part, responsible for its cytotoxicity. Flavoglaucin was toxic to isolated rat hepatocytes causing a karyoklasis, but did not show genotoxicity in hepatocyte primary culture (HPC)/DNA repair test.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Kawai K,Mori H,Kitamura Jdoi
10.1016/0378-4274(83)90137-6subject
Has Abstractpub_date
1983-12-01 00:00:00pages
321-5issue
3eissn
0378-4274issn
1879-3169pii
0378-4274(83)90137-6journal_volume
19pub_type
杂志文章abstract::Fumonisin B1 (FB1) and beauvericin (BEA) are secondary metabolites of filamentous fungi, which under appropriate temperature and humidity conditions may develop on various foods and feeds. To date few studies have been performed to evaluate the toxicological and endocrine disrupting effects of FB1 and BEA. The present...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2016.05.021
更新日期:2016-08-22 00:00:00
abstract::The neurotoxic, genotoxic and carcinogenic effects of industrial exposure to acrylamide have been studied in animals and humans for more than 30 years. A recent search for the cause of high background levels of acrylamide in industrially unexposed people revealed that it is formed during the frying or baking of foods ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2004.04.037
更新日期:2004-09-10 00:00:00
abstract::Conversion of hepatic stellate cells (HSCs) into hepatic myofibroblasts is a necessary event during the development of liver fibrosis. DNA methyltransferase 1 (DNMT1), which catalyzes DNA methylation and subsequently leads to the transcriptional repression of profibrotic genes, is selectively induced in myofibroblasts...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2013.10.038
更新日期:2014-01-13 00:00:00
abstract::The test based on measuring the RNA synthesis rate, already described on Hela S3 in culture (Fauris et al., Les colloques de l'INSERM 106 (1981) 455-463), has been adapted to a human hepatoma cell line Hep 3B which retains a certain capacity towards metabolising. These modifications make it easier to point to the pres...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(94)90090-6
更新日期:1994-11-01 00:00:00
abstract::Intraperitoneal injection of the iron-complex, ferric-nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage associated with oxidative damage in vivo. Fe-NTA induced a time-dependent decrease of several polyunsaturated fatty acids (PUFA), together with increased conjugated diene values and decreased cellula...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(01)00372-1
更新日期:2001-09-15 00:00:00
abstract::Hyperbilirubinemia is a common clinical phenomenon observed in human newborns. A high level of bilirubin can result in severe jaundice and bilirubin encephalopathy. However, the cellular mechanisms underlying bilirubin excitotoxicity are unclear. Our previous studies showed the action of gamma-aminobutyric acid (GABA)...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2015.10.008
更新日期:2016-01-05 00:00:00
abstract::1,2-Dioxetanes, very reactive and high energy molecules, are involved as labile intermediates in dioxygenase-activated aerobic metabolism and in physiological processes. Various toxicological tests reveal that dioxetanes are indeed genotoxic. In supercoiled DNA of bacteriophage PM2 they induce endonuclease-sensitive s...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(93)90045-y
更新日期:1993-04-01 00:00:00
abstract::Ambient and biological monitoring was undertaken among tobacco processors who are chronically exposed to tobacco particulates via nasopharyngeal and cutaneous routes. Ambient monitoring revealed that the inspirable dust concentration was 150-fold higher in the tobacco factory than in the control environment, and was a...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(99)00097-1
更新日期:1999-09-05 00:00:00
abstract::Exposure to high levels of persistent pollutants, such as metal mixtures, is commonly encountered by the general population especially in industrialized countries. The aim of this work was to evaluate how metal pollution in contaminated areas is reflected in terms of biomarkers (BMs) of exposure and effect in human su...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2019.12.022
更新日期:2020-05-15 00:00:00
abstract::The role of intra- and extracellular calcium in the activation of human polymorphonuclear leukocytes (PMNL) to produce reactive oxygen metabolites (ROM) were studied by using soluble, formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol myristate acetate (PMA), or particulate stimuli, quartz or chrysotile. A calciu...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(95)03255-j
更新日期:1995-08-01 00:00:00
abstract::Previous studies indicated that the enantiomers of thalidomide and its analogue EM12 exhibit differing teratogenic potencies. Unfortunately, these substances proved to be unstable and racemised considerably, so that the intrinsic teratogenic potencies of the pure enantiomers were difficult to elucidate. We have theref...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(89)90099-4
更新日期:1989-10-01 00:00:00
abstract::There are multiple lines of evidence showing that environmental toxicants including pesticides may contribute to neuronal cell death. Fipronil (FPN) is a phenylpyrazole insecticide that acts on insect GABA receptors. Although the action of FPN is restricted to insect neuronal or muscular transmitter systems, a few stu...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2012.02.022
更新日期:2012-05-20 00:00:00
abstract::The liver carcinogen N-nitrosodimethylamine (NDMA) has to be metabolically activated by specific cytochromes before it can react with cellular macromolecules (e.g. proteins or DNA). Although hepatocytes are believed to be responsible for this activation, the liver tumours originate mainly from non-parenchymal cells (N...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(01)00400-3
更新日期:2001-09-15 00:00:00
abstract::An in vivo intestinal perfusion technique was used to measure the absorption rates of five Cr compounds in black ducks. Cr was absorbed from saline solutions of KCr(SO4)2 and CrO3 at a rate about 1.5 to 2.0 times greater than from solutions of Cr, Cr(NO3)3, and Cr(C5H7O2)3. These results suggest the ionic form of Cr i...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(80)90191-5
更新日期:1980-08-01 00:00:00
abstract::Mechanism of PAH mixtures, using granulosa tumour cells, was investigated. Cells were exposed to a mixture of all 16 priority PAHs (M1) or a mixture of five PAHs not classified as human carcinogens (M2). The effect of siAHR, siAHRR and siNFKB2 on the expression of CYP1A1, CYP1B1, GSTM1, ERα, AR and cell proliferation ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2019.04.008
更新日期:2019-08-01 00:00:00
abstract::Several pesticides used as herbicides, insecticides and fungicides are known to be endocrine disrupting chemicals (EDCs). In three pair-matched studies we found changes in sex hormone concentrations and T-lymphocytes in relation to acute and chronic pesticide exposure. After acute exposure, 1 day later the concentrati...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(99)00051-x
更新日期:1999-06-30 00:00:00
abstract::Pregnant CD-1 mice were given 32 mg/kg of 3,4,3',4'-tetrachlorobiphenyl (TCB) or corn oil vehicle, by gavage, on days 10--16 of gestation. At 1 year of age, the offspring were tested for spontaneous motor activity; the mice were then killed and dopamine (DA) levels and specific DA receptor binding were measured in the...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(81)90087-4
更新日期:1981-03-01 00:00:00
abstract::Intraperitoneal injection (50 mg/kg) of 2-nitropropane (2-NP) induced lipid accumulation, centrilobular necrosis, degranulation of rough endoplasmic reticulum, proliferation of smooth endoplasmic reticulum and mitochondrial abnormalities in rat liver 24 h after exposure. These pathological changes were accompanied by ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(81)90156-9
更新日期:1981-11-01 00:00:00
abstract::For the past 10 years we have focused on the development of antisense treatments against viral infections such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV). We have demonstrated that phosphorothioate oligomers have in vitro anti-HIV activities and in vivo anti-HBV activity. In vitro anti-HIV activ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(95)03574-5
更新日期:1995-12-01 00:00:00
abstract::Upon entering the body, nerve agents can bind active amino acid residues to form phosphonylated adducts. Tabun derivatives (O-alkyl-N,N-dialkyl phosphoroamidocyanidates) have strikingly different structural features from other G-series nerve agents, such as sarin and soman. Here, we investigate the binding mechanism f...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2019.12.014
更新日期:2020-03-15 00:00:00
abstract::The grazing trial at Kidston Gold Mine, North Queensland, was aimed specifically to assess the uptake of metals from the tailing and the potential for unacceptable contamination of saleable meat. Further aims included estimating metal dose rates and identifying potential exposure pathways including plant uptake of hea...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(02)00378-8
更新日期:2003-01-31 00:00:00
abstract::Pneumotoxicity of butylated hydroxytoluene (BHT) applied to the skin of CD-1 mice was investigated and compared with that of butylated hydroxyanisole (BHA). To 6 groups of 10 male mice and 10 female mice 0.1 ml of dimethylsulfoxide (DMSO) solutions containing 0, 5, 10, 20, or 30 mg of BHT or 30 mg of BHA were topicall...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(86)90151-7
更新日期:1986-11-01 00:00:00
abstract::The toxic and teratogenic effects of 4 organophosphorus compounds (phenyl saliginen cyclic phosphate (PSCP), leptophos-oxon (LPTO), tri-o-tolyl phosphate (TOTP), and paraoxon (PXN] were investigated in the embryos of 3 species of frogs. Developmental abnormalities were observed in surviving embryos of each of the 3 sp...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(85)90163-8
更新日期:1985-08-01 00:00:00
abstract::Pyrethroids are neurotoxic insecticides showing significant selective toxicity on insects over mammals, but effects on mammalian nervous system are not negligible. These substances act on the voltage-gated sodium channel, prolonging the duration of the open state. The present study focused on the effect of the pyrethr...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2016.12.012
更新日期:2017-02-05 00:00:00
abstract::Primary cultures of rat hepatocytes were exposed to various concentrations of L-asparaginase derived from Escherichia Coli. Protein synthesis was inhibited by about 33% and cellular glutamine was reduced proportionally to the enzyme concentration. However, protein synthesis was inhibited only by amounts of enzyme able...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(86)90113-x
更新日期:1986-09-01 00:00:00
abstract::The main objective of this work was to assess the potentiality of in vitro models to study and understand the uranium-induced cytotoxicity on renal cells. Cytotoxicity and morphological studies were performed in a tubular proximal original established cell line (LLC-PK1 cell line). Dose-dependent cytotoxicity response...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(98)00371-3
更新日期:1999-02-22 00:00:00
abstract::Treatment of young male rats with dipentyl phthalate (DPP) produced significant decreases in testicular cytochrome P-450, cytochrome P-450 dependent microsomal steroidogenic enzymes (17 alpha-hydroxylase, 17-20 lyase) and in the maximal binding of a natural substrate (progesterone) to testis microsomes. No effect was ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(83)90226-6
更新日期:1983-02-01 00:00:00
abstract::New psychoactive substances (NPS) are an increasing problem in clinical and forensic toxicology. The knowledge of their metabolism is important for toxicological risk assessment and for developing toxicological urine screenings. Considering the huge numbers of NPS annually appearing on the market, metabolism studies s...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2017.07.901
更新日期:2017-10-05 00:00:00
abstract::The capacity of the trichothecene T-2 toxin to alter resistance to bacterial lipopolysaccharide (LPS) was examined in the mouse. Both LPS-susceptible (C3H/HeN) and LPS-resistant (C3H/HeJ) mouse strains exhibited markedly enhanced mortality when a single oral dose of T-2 toxin (1 mg/kg) was coadministered with a subacu...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(88)90146-4
更新日期:1988-11-01 00:00:00
abstract::Morphological malformations induced by tributyltin (TBT) exposure during embryonic development have already been characterized in various taxonomic groups, but, nonetheless, the molecular processes underlying these changes remain obscure. The present study provides the first genome-wide screening for differentially ex...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2017.11.019
更新日期:2018-03-01 00:00:00