Abstract:
:Pregnant CD-1 mice were given 32 mg/kg of 3,4,3',4'-tetrachlorobiphenyl (TCB) or corn oil vehicle, by gavage, on days 10--16 of gestation. At 1 year of age, the offspring were tested for spontaneous motor activity; the mice were then killed and dopamine (DA) levels and specific DA receptor binding were measured in the corpus striatum. Mice exposed to TCB in utero had elevated levels of motor activity, which were associated with decreased DA levels and DA receptor binding sites. The results indicate that in utero exposure to TCB might permanently alter the development of striatal synapses.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Agrawal AK,Tilson HA,Bondy SCdoi
10.1016/0378-4274(81)90087-4subject
Has Abstractpub_date
1981-03-01 00:00:00pages
417-24issue
6eissn
0378-4274issn
1879-3169pii
0378-4274(81)90087-4journal_volume
7pub_type
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journal_title:Toxicology letters
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journal_title:Toxicology letters
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更新日期:1981-10-01 00:00:00
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更新日期:2016-11-16 00:00:00
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journal_title:Toxicology letters
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doi:10.1016/0378-4274(81)90112-0
更新日期:1981-06-01 00:00:00
abstract::The proceedings in this volume suggest several important future research needs. Research is needed to validate modeling in toxicology in order to support the use of the general approach of modeling, either for structure-activity relationships (SAR) or physiologically based pharmacokinetics (PBPK), by regulators. Resea...
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更新日期:1995-09-01 00:00:00
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journal_title:Toxicology letters
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更新日期:1980-01-01 00:00:00
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journal_title:Toxicology letters
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更新日期:2002-06-07 00:00:00
abstract::The phthalates di(2-ethylhexyl)phthalate (DEHP) and di-n-butyl phthalate (DBP) are environmental contaminants with significant human exposures. Both compounds are known reproductive toxins in rodents and DEHP also induces rodent hepatocarcinogenesis in a process believed to be mediated via the peroxisome proliferator-...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2005.11.001
更新日期:2006-06-01 00:00:00
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:1991-04-01 00:00:00