Compounds of PAH mixtures dependent interaction between multiple signaling pathways in granulosa tumour cells.

abstract：:The toxicity of diethylene glycol butyl ether (DGBE), and its principal metabolite, butoxyethoxyacetic acid (BEAA), were assessed in vitro for rat and human red blood cells. Rat erythrocytes showed evidence of mild hemolysis when exposed to BEAA at concentrations of 5 or 10 mM for 4 h. BEAA treated rat red blood cells...

journal_title：Toxicology letters

authors： Udden MM

更新日期：2005-03-28 00:00:00

abstract：:The polychlorinated biphenyls (PCBs) have been demonstrated to be inducers of hepatic microsomal enzymes and some of their effects such as hormonal imbalance, and alteration of lipid and porphyrin metabolism could be ascribed to this mechanism. For this reason, the urinary excretion of D-glucaric acid (DGA), an indire...

journal_title：Toxicology letters

authors： Apostoli P,Mangili A,Carasi S,Manno M

更新日期：2003-09-15 00:00:00

abstract：:Over the last twenty years research has provided an important insight into the mechanisms responsible for the immunotoxicity of both local and systemic adverse reactions following the use of immunostimulating drugs and adjuvants. In this article we provide an update of the present knowledge relating to the various par...

journal_title：Toxicology letters

authors： Batista-Duharte A,Lindblad EB,Oviedo-Orta E

更新日期：2011-06-10 00:00:00

abstract：:The mammalian xenobiotic-metabolizing sulfotransferases are cytosolic enzymes, which form a gene superfamily (SULT). Ten distinct human SULT forms are known. Two SULT forms represent splice variants, the other forms are encoded by separate genes. Common functional polymorphisms of the transcribed region are known for ...

journal_title：Toxicology letters

authors： Glatt H,Engelke CE,Pabel U,Teubner W,Jones AL,Coughtrie MW,Andrae U,Falany CN,Meinl W

更新日期：2000-03-15 00:00:00

abstract：:Using equimolar quantities of 2 chemical allergens, toluene diisocyanate (TDI), noted for its ability to cause respiratory hypersensitivity, and dinitrochlorobenzene (DNCB), noted for its dermal sensitizing activity, the mouse was evaluated as a possible model to indicate respiratory hypersensitivity. A previously pub...

journal_title：Toxicology letters

authors： Satoh T,Kramarik JA,Tollerud DJ,Karol MH

更新日期：1995-06-01 00:00:00

abstract：:The increasing industrial use of nanoparticles (NPs) has raised concerns about their impact on human health. Since aging and exposure to environmental factors are linked to the risk for developing pathologies, we address the question of TiO2 NPs toxicokinetics in the context of a realistic occupational exposure. We re...

journal_title：Toxicology letters

authors： Gaté L,Disdier C,Cosnier F,Gagnaire F,Devoy J,Saba W,Brun E,Chalansonnet M,Mabondzo A

更新日期：2017-01-04 00:00:00

abstract：:A single s.c. injection of 60 mg/kg of monocrotaline to rats induced pulmonary alterations characterized by hyaline thrombi of capillaries and arterioles, focal necrosis of alveolar walls, and medial thickening and intimal hyalinosis of arteries. Such pathological alterations became apparent 7 days after injection and...

journal_title：Toxicology letters

authors： Hayashi Y,Kokubo T,Takahashi M,Furukawa F,Otsuka H,Hashimoto K

更新日期：1984-04-01 00:00:00

abstract：:Dioxins are persistent environmental contaminants that cause multiple disorders in laboratory animals, including teratogenesis. In mice, the most important teratogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are hydronephrosis and cleft palate. Aryl hydrocarbon receptor (AHR) mediates most of the TCDD-in...

journal_title：Toxicology letters

authors： Miettinen HM,Huuskonen H,Partanen AM,Miettinen P,Tuomisto JT,Pohjanvirta R,Tuomisto J

更新日期：2004-05-02 00:00:00

abstract：:Recently, we reported that silver nanoparticles (AgNPs) induced reactive oxygen species (ROS) generation and the resultant oxidative stress contributes to the cell damage associated with AgNPs. 8-Oxoguanine (8-oxoG) is sensitive marker of ROS-induced DNA damage. 8-Oxoguanine DNA glycosylase 1 (OGG1) is an important DN...

journal_title：Toxicology letters

authors： Piao MJ,Kim KC,Choi JY,Choi J,Hyun JW

更新日期：2011-11-30 00:00:00

abstract：:Hypoallergenic infant formulas are widely used for infants with cow's milk allergy. The aim of this study was to assess the utility of the mouse basophil activation test (BAT) in the evaluation of residual antigenicity in these formulas. Whole blood samples derived from β-lactoglobulin- or casein-immunized mice were i...

journal_title：Toxicology letters

authors： Iwamoto H,Matsubara T,Nakazato Y,Namba K,Takeda Y

更新日期：2016-02-03 00:00:00

abstract：:Several perfluoroalkyl compounds (PFCs) are ubiquitous environmental contaminants that can biomagnify in species at high trophic levels including wild birds. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) have been detected in wild birds and are known to reduce hatching success of laboratory-expose...

journal_title：Toxicology letters

authors： O'Brien JM,Crump D,Mundy LJ,Chu S,McLaren KK,Vongphachan V,Letcher RJ,Kennedy SW

更新日期：2009-10-28 00:00:00

abstract：:Overexposure to manganese (Mn) has been known to induce neuronal death and neurodegenerative symptoms. However, the precise mechanisms underlying Mn neurotoxicity remain incompletely understood. In the present study, we established a Mn-exposed rat model and found that downregulation of wild type p53-induced phosphata...

journal_title：Toxicology letters

authors： Ma X,Han J,Wu Q,Liu H,Shi S,Wang C,Wang Y,Xiao J,Zhao J,Jiang J,Wan C

更新日期：2015-05-19 00:00:00

abstract：:When pregnant mice were exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the average time to eye opening in the offspring was shortened by about a day. How acceleration of eye opening by TCDD occurs remains unknown. To reveal the underlying mechanisms of the accelerated eye opening, pregnant mice were intraperit...

journal_title：Toxicology letters

authors： Gin DW,Kim HR,Lee DM,Lee SH,Seong AR,Hwang JA,Park JH

更新日期：2010-07-01 00:00:00

abstract：:Trichothecenes are mycotoxins which produce lethal toxicosis in humans and animals, yet no adequate therapeutic regimen has been developed. This study provides evidence that the selective platelet activating factor (PAF) antagonist, BN 52021 (5-15 mg/kg i.v.) can prolong the survival of conscious rats exposed to a hig...

journal_title：Toxicology letters

authors： Feuerstein G,Leader P,Siren AL,Braquet P

更新日期：1987-10-01 00:00:00

abstract：:Hepatic and renal microsomal electron transport components and erythrocyte delta-aminolevulinate dehydratase were investigated in adult male rats exposed to 0, 50, 200 and 600 ppm tetrachloroethylene for 4 weeks. Body weight and liver weight showed a significant decrease only in the 600 ppm group. A dose-dependent dec...

journal_title：Toxicology letters

authors： Soni M,Nomiyama H,Nomiyama K

更新日期：1990-12-01 00:00:00

abstract：:One of the major dose-limiting toxicities induced by antimicrotubule antitumor agents such as vinca alkaloids and taxanes is peripheral neuropathy. The neurotoxicity of TZT-1027 (a dolastatin 10 derivative antimicrotubule agent) was thus assessed using the animal models for antimicrotubule agent-induced neurotoxicity....

journal_title：Toxicology letters

authors： Ogawa T,Mimura Y,Isowa K,Kato H,Mitsuishi M,Toyoshi T,Kuwayama N,Morimoto H,Murakoshi M,Nakayama T

更新日期：2001-04-30 00:00:00

abstract：:A major issue of inhalation toxicity is that of dose. An inhaled dose is more difficult to determine than the dose from other routes of administration. Via oral or parenteral routes, a discrete amount of test substance is given in a bolus. In inhalation toxicology, the delivered dose depends on the exposure concentrat...

journal_title：Toxicology letters

authors： Pauluhn J

更新日期：2003-04-11 00:00:00

abstract：:The classical way to demonstrate the efficiency of remediation is measuring the reduction of toxic compounds in the environment. Nevertheless, more important is the risk reduction in human health. To determine changing health effects, exposure and bio-effects have to be monitored at time of and during remediation. Kin...

journal_title：Toxicology letters

authors： Rolle-Kampczyk UE,Rehwagen M,Franck U,Weiss H,Krumbiegel P,Herbarth O

更新日期：2006-04-10 00:00:00

abstract：:Bothrops (lance-head pit vipers) venoms are rich in weaponised metalloprotease enzymes (SVMP). These toxic enzymes are structurally diverse and functionally versatile. Potent coagulotoxicity is particularly important for prey capture (via stroke-induction) and relevant to human clinical cases (due to consumption of cl...

journal_title：Toxicology letters

authors： Sousa LF,Bernardoni JL,Zdenek CN,Dobson J,Coimbra F,Gillett A,Lopes-Ferreira M,Moura-da-Silva AM,Fry BG

更新日期：2020-10-15 00:00:00

abstract：:In vivo experiments are still widely used for the testing of lung toxicity but there is an ethical and legal obligation to replace, reduce and refine animal testing. Lung A549 cells could serve as an in vitro indicator for acute lung toxicity but little data about the correlation of the cytotoxicity in A549 cells and ...

journal_title：Toxicology letters

authors： Gohlsch K,Mückter H,Steinritz D,Aufderheide M,Hoffmann S,Gudermann T,Breit A

更新日期：2019-11-01 00:00:00

abstract：:Samples of PM(2.5) were gravimetrically collected during the winter 2005/2006 in the urban area of Milan (North Italy). Samples were chemically characterized and the particles were detached from filters to determine their cytotoxic effects on the A549 cell line. Based on the potential toxicological relevance of its co...

journal_title：Toxicology letters

authors： Gualtieri M,Mantecca P,Corvaja V,Longhin E,Perrone MG,Bolzacchini E,Camatini M

更新日期：2009-07-10 00:00:00

abstract：:The possible embryotoxic effects of cyclohexylamine hydrochloride doses (expressed as free base) of 10, 30 and 100 mg/kg of body weight per day administered orally in water to mice and rats from the 6th to 15th day post-coitum were investigated. Treatment with daily doses of up to 100 mg/kg of body weight to mice and ...

journal_title：Toxicology letters

authors： Lorke D,Machemer L

更新日期：1983-06-01 00:00:00

abstract：:Trihalomethanes (THMs; chloroform, bromoform, bromodichloromethane, dibromochloromethane), formed as by-products of chlorine disinfection, are found to occur in combination in drinking water supplies. THMs are metabolized by cytochromes P-450 and are likely substrates of CYP2E1. Therefore, it is possible that mixed ex...

journal_title：Toxicology letters

authors： Luciene da Silva M,Charest-Tardif G,Krishnan K,Tardif R

更新日期：1999-05-20 00:00:00

abstract：:The skin absorption of aniline, aniline with 3% water content, and 1 and 2% aqueous aniline solutions was investigated in man. The time of exposure was 30 or 60 min. The absorbed amount of aniline was calculated on the basis of rho-aminophenol excretion in 24-h urine. The rate of aniline absorption from aqueous soluti...

journal_title：Toxicology letters

authors： Baranowska-Dutkeiwicz B

更新日期：1982-03-01 00:00:00

abstract：:Grain should be harvested at lowest possible humidity, or immediately dried to safe storage humidity to prevent the growth of fungi. Critical steps of grain harvest like conditions of used combine harvester, temperatures and aeration are discussed on their impact on mycotoxin formation. ...

journal_title：Toxicology letters

authors： Schrödter R

更新日期：2004-10-10 00:00:00

abstract：:Colistin is a polypeptide antibiotic that effectively treats infections caused by multidrug-resistant Gram-negative bacteria, but its clinical use is limited due to nephrotoxicity. The purpose of the present study was to identify biomarkers of colistin-induced nephrotoxicity and to further characterize the mechanisms ...

journal_title：Toxicology letters

authors： Jeong ES,Kim G,Moon KS,Kim YB,Oh JH,Kim HS,Jeong J,Shin JG,Kim DH

更新日期：2016-04-25 00:00:00

abstract：:Mutagenic activity of aflatoxin B1 (AFB1) was followed in the Ames Salmonella/microsome test using liver S-9 from control and partially hepatectomized (PH) mice. The S-9 preparations from the PH mice were capable of inducing significantly greater AFB1 mutagenic activity to strain TA100 than S-9 preparations from eithe...

journal_title：Toxicology letters

authors： Vandewaa EA,Barney CC,Gentile JM

更新日期：1982-12-01 00:00:00

abstract：:Traditional gold mining, using metallic mercury (Hg(0)) to form gold amalgam, followed by burning to remove the Hg(0), is widely used in South America, Africa and Asia. The gold is sold to merchants who burn it again to eliminate remaining Hg(0). In Ecuador, 200 gold miners, 37 gold merchants and 72 referents were stu...

journal_title：Toxicology letters

authors： Harari R,Harari F,Gerhardsson L,Lundh T,Skerfving S,Strömberg U,Broberg K

更新日期：2012-08-13 00:00:00

abstract：:Between 1997 and 2011, more than 200 new substances were notified through the early-warning system, with the record number of 49 novel molecules reported in 2011. The pattern of acute toxicity associated with the consumption of these new substances is generally similar to that seen with traditional drugs of abuse. Rec...

journal_title：Toxicology letters

authors： Coppola M,Mondola R

更新日期：2012-07-07 00:00:00

abstract：:The European Commission has decided on harmonized classifications for a large number of individual chemicals according to its own directive for classification and labeling of dangerous substances. We have compared the harmonized classifications for acute oral toxicity to the acute oral toxicity data available in the R...

journal_title：Toxicology letters

authors： Rudén C,Hansson SO

更新日期：2003-09-30 00:00:00