Genotoxicity of the isoflavones genistein, daidzein and equol in V79 cells.

abstract：:Women over 50 years of age in 32 cadmium(Cd)-polluted and 16 nonpolluted hamlets were studied. Itai-itai disease patients and proteinuria with glucosuria were used as indices of the effect of Cd on health. Unpolished rice samples were collected from 568 households in the same area and analyzed for Cd. The hamlet's ave...

journal_title：Toxicology letters

authors： Nogawa K,Yamada Y,Honda R,Ishizaki M,Tsuritani I,Kawano S,Kato T

更新日期：1983-07-01 00:00:00

abstract：:Lead is a toxic heavy metal with many recognized adverse health side effects. The central nervous system is the main target of lead toxicity. Although many studies on lead toxicity were conducted, the mechanism of lead toxicity remains uncertain. One possible attribution is the immature blood-brain barrier that causes...

journal_title：Toxicology letters

authors： Yang Y,Zhang X,Fu Y,Yang H

更新日期：2014-06-16 00:00:00

abstract：:Cadmium (Cd), which accumulates primarily in the liver and the kidney, induces apoptosis and also causes necrotic cell death in certain pathophysiologic situations. Previously, we have shown that Cd activated mitogen-activated protein kinases and that sulfur amino acid deficiency potentiated Cd-induced cytotoxicity vi...

journal_title：Toxicology letters

authors： Kim SC,Cho MK,Kim SG

更新日期：2003-10-15 00:00:00

abstract：:The dose-dependent effects of sodium saccharin on the fertility and the induction of chromosomal translocations in treated mice and their F1 males were examined. C3H X 101 mice were treated with saccharin for 2 successive weeks at doses of 200 and 500 mg/kg of body wt. Data from the fertility study showed that sacchar...

journal_title：Toxicology letters

authors： Pecevski J,Vuksanović L,Savković N,Alavantić D,Radivojević D

更新日期：1983-12-01 00:00:00

abstract：:Acetaminophen is a widely used analgesic, which has exhibited evidence of estrogenic activity in estrogen-receptor positive human breast cancer cells. However, there is limited in vivo experimentation regarding the estrogenicity of acetaminophen. Therefore, the present study examined the in vivo estrogenic potential o...

journal_title：Toxicology letters

authors： Patel R,Rosengren RJ

更新日期：2001-05-31 00:00:00

abstract：:Free fatty acids (FFA), commonly elevated in diabetes and obesity, have been shown to impair endothelial functions and cause oxidative stress, inflammation, and insulin resistance. Anthocyanins represent one of the most important and interesting classes of flavonoids and seem to play a role in preventing cardiovascula...

journal_title：Toxicology letters

authors： Fratantonio D,Speciale A,Ferrari D,Cristani M,Saija A,Cimino F

更新日期：2015-12-15 00:00:00

abstract：:The antioxidant activity of genistein is associated with preventing atherosclerosis; however, the underlying mechanisms are not fully understood. In this study, human umbilical vein endothelial cells (HUVECs) were pretreated with genistein at different concentrations (10nM, 100nM and 1000nM) for 6h and then exposed to...

journal_title：Toxicology letters

authors： Zhang H,Zhao Z,Pang X,Yang J,Yu H,Zhang Y,Zhou H,Zhao J

更新日期：2017-08-05 00:00:00

abstract：:Plant protection products have to be evaluated and authorized in the EC-Member States since 1993 in accordance with Directive 91/414/EEC. The programme for evaluating existing active substances (which were on the market before July 1993) involves several steps and stages, stretching over a period of up to formerly 10,...

journal_title：Toxicology letters

authors： Flynn DJ,Lundehn JR

更新日期：2004-04-01 00:00:00

abstract：:Lead (Pb) is a toxic heavy metal widespreadly used in industrial field. Prior studies showed that Pb exposure had detrimental effects on osteoblasts. The mechanisms underlying Pb-induced damage are complex. Autophagy can protect cells from various cytotoxic stimuli. In the present study, the aim of our research was to...

journal_title：Toxicology letters

authors： Lv XH,Zhao DH,Cai SZ,Luo SY,You T,Xu BL,Chen K

更新日期：2015-12-03 00:00:00

abstract：:Propylene oxide (PO) concentrations >or=300 ppm induced cell proliferation and tumors in rat nasal respiratory epithelium (NRE). Cell proliferation was suggested to result from depletion of glutathione (GSH) in NRE. In order to substantiate this hypothesis, cell proliferation - measured by bromodeoxyuridine incorporat...

journal_title：Toxicology letters

authors： Khan MD,Klein D,Mossbrugger I,Oesterle D,Csanády GA,Quintanilla-Martinez L,Filser JG

更新日期：2009-03-28 00:00:00

abstract：:The effect of dietary vomitoxin on the serum IgA and IgG responses to two model intestinal antigens, casein and cholera toxin (CT), were assessed in 4 experimental groups: (1) mice fed casein-based diet, (2) mice fed casein-based diet containing 25 ppm vomitoxin, (3) mice fed casein-based diet and immunized with CT, a...

journal_title：Toxicology letters

authors： Pestka JJ,Moorman MA,Warner RL

更新日期：1990-01-01 00:00:00

abstract：:Fluorocarbons containing chlorine or bromine have been associated with stratospheric ozone depletion and the search for suitable alternatives is progressing at an accelerated pace. The Program for Alternative Fluorocarbon Toxicity Testing (PAFT), an international group representing most of the world's CFC producers, h...

journal_title：Toxicology letters

authors： Trochimowicz HJ

更新日期：1993-05-01 00:00:00

abstract：:The subacute nephrotoxicity of more than 20 industrial solvents has been compared in female Sprague-Dawley rats. The animals were given 5 i.p. injections of the solvents per week for 2 weeks at doses ranging from 1/20 to 1/5 of the i.p. or oral LD50 and the urinary excretion of N-acetyl-beta-D-glucosaminidase, beta 2-...

journal_title：Toxicology letters

authors： Bernard AM,de Russis R,Normand JC,Lauwerys RR

更新日期：1989-02-01 00:00:00

abstract：:Sulfur mustard (SM) is a chemical warfare agent causing blistering, inflammation and ulceration of the skin. Thiol compounds such as glutathione (GSH) and N-acetylcysteine (NAC) have been suggested as potential antidotes. We investigated SM toxicity in a human keratinocyte cell line (HaCaT) and used GSH and NAC to cou...

journal_title：Toxicology letters

authors： Balszuweit F,Menacher G,Schmidt A,Kehe K,Popp T,Worek F,Thiermann H,Steinritz D

更新日期：2016-02-26 00:00:00

abstract：:Cadmium is a toxic heavy metal which has been shown to be a possible risk factor of atherosclerosis in epidemiological and experimental studies. Since intimal hyperplasia in vascular tissue is an important component of atherosclerosis, we examined the effect of cadmium on the proliferation of vascular smooth muscle ce...

journal_title：Toxicology letters

authors： Fujiwara Y,Watanabe S,Kaji T

更新日期：1998-02-01 00:00:00

abstract：:Iron is a unique poison because it is not a xenobiotic. It is an essential element and highly reactive. Because of the critical dependence upon iron and its potential to damage tissues, elaborate mechanisms have evolved for its efficient absorption, transport, cellular uptake, storage and conservation. These are incom...

journal_title：Toxicology letters

authors： Tenenbein M

更新日期：1998-12-28 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an environmental toxin that induces apoptosis of neurons and a pro-inflammatory response in microglial cells. First, we found that TCDD induced proliferation of HAPI microglial cells in a dose- and time-dependent manner. Flow cytometry analysis showed that this proliferati...

journal_title：Toxicology letters

authors： Xu G,Li Y,Yoshimoto K,Wu Q,Chen G,Iwata T,Mizusawa N,Wan C,Nie X

更新日期：2014-01-30 00:00:00

abstract：:In order to evaluate the possibility that the metabolism of pyridine may be important for its toxic actions, pyridine was compared with pyridine N-oxide, 2-hydroxypyridine, 3-hydroxypyridine, 4-hydroxypyridine and pyridinium methyliodide in rats given equal molar doses of the chemicals i.p. Hepatoxicity was assessed b...

journal_title：Toxicology letters

authors： Carlson GP

更新日期：1996-06-01 00:00:00

abstract：:Exposure to chemicals released during urban waste disposal and treatment is increasingly regarded as a potential occupational health issue. Indeed, several toxic metals emitted by an incinerator, including As, Be, Cd, Cr, Pb, Mn, Hg, Ni and V, have potentially toxic properties and their exposure, therefore, may be of ...

journal_title：Toxicology letters

authors： Mauriello MC,Sbordone C,Montuori P,Alfano R,Triassi M,Iavicoli I,Manno M

更新日期：2017-04-15 00:00:00

abstract：:Alternaria spp. are ubiquitous molds that are able to produce toxic secondary metabolites which may contaminate food globally. One of those is the mycotoxin altertoxin II (ATX-II), a genotoxic and mutagenic compound. In recent years, different flavonoids that may co-occur with mycotoxins in food were demonstrated to t...

journal_title：Toxicology letters

authors： Aichinger G,Puntscher H,Beisl J,Kütt ML,Warth B,Marko D

更新日期：2018-03-01 00:00:00

abstract：:The gut microbiome has tremendous potential to impact health and disease. Various environmental toxicants, including insecticides, have been shown to alter gut microbiome community structures. However, the mechanism that compositionally and functionally regulates gut microbiota remains unclear. Quorum sensing is known...

journal_title：Toxicology letters

authors： Gao B,Chi L,Tu P,Bian X,Thomas J,Ru H,Lu K

更新日期：2018-02-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is a DNA-binding protein that is abundantly expressed in most tissues. Recently, HMGB1 has gained much attention for its regulation of immunity and inflammation. Yet its role in toluene diisocyanate (TDI)-induced asthma still remains poorly characterized. In this study, mice were sens...

journal_title：Toxicology letters

authors： Yao L,Zhao H,Tang H,Song J,Dong H,Zou F,Cai S

更新日期：2015-11-19 00:00:00

abstract：:Toxicity of an aqueous extract prepared from Echinodorus macrophyllus dried leaves, a plant used in folk medicine to treat inflammation and kidney malfunctions, was estimated by different bioassays. Mutagenicity of the aqueous extract was evaluated in the Salmonella/microsome assay (TA97a, TA98, TA100 and TA102 strain...

journal_title：Toxicology letters

authors： da Costa Lopes L,Albano F,Augusto Travassos Laranja G,Marques Alves L,Fernando Martins e Silva L,Poubel de Souza G,de Magalhães Araujo I,Firmino Nogueira-Neto J,Felzenszwalb I,Kovary K

更新日期：2000-08-16 00:00:00

abstract：:Styrene-acrylonitrile trimer (SAN Trimer), a mixture of six isomers (four isomers of 4-cyano-1,2,3,4-tetrahydro-alpha-methyl-1-naphthaleneacetonitrile [THAN] and two isomers of 4-cyano-1,2,3,4-tetrahydro-1-naphthaleneproprionitrile [THNP]), is a by-product of a specific production process of styrene-acrylonitrile poly...

journal_title：Toxicology letters

authors： Gargas ML,Collins B,Fennell TR,Gaudette NF Jr,Sweeney LM

更新日期：2008-04-21 00:00:00

abstract：:Victims of nerve agents basically require antidotal treatment. There is need for novel antidotes and for therapeutic procedures that are specifically adapted to these patients. To cope with this challenge, in vitro test systems which are easy to handle and allow for conducting long-term studies would be of great benef...

journal_title：Toxicology letters

authors： Drexler B,Seeger T,Grasshoff C,Thiermann H,Antkowiak B

更新日期：2011-09-25 00:00:00

abstract：:The effect of copper (Cu) deficiency on antioxidant status of liver and heart and its effect on adriamycin toxicity was assessed. Weanling rats were fed Cu-adequate (+Cu) and Cu-deficient (-Cu) diets for 3 weeks and then injected intraperitoneally once with saline or adriamycin (8 mg/kg). All -Cu rats had increased he...

journal_title：Toxicology letters

authors： Fischer J,Johnson MA,Tackett RL

更新日期：1991-07-01 00:00:00

abstract：:An overview of values for the threshold of toxicological concern (TTC) is presented. This comprises the more established TTC values, including those that have been endorsed by regulatory bodies, and those that have more recently been proposed and may still need further development. The overview is structured by use/ex...

journal_title：Toxicology letters

authors： Hennes EC

更新日期：2012-06-20 00:00:00

abstract：:Prior research suggests that sex hormones and metabolic changes, such as obesity and hyperglycemia, can alter renal transporter expression in rodents. The purpose of this study was to characterize the expression of kidney efflux transporters and regulatory transcription factors in response to Type I diabetes and pregn...

journal_title：Toxicology letters

authors： Yacovino LL,Aleksunes LM

更新日期：2012-06-20 00:00:00

abstract：:Chemical warfare agents, such as soman, and pesticides, such as chlorpyrifos, dichlorvos or malathion, are toxic organophosphorous compounds (OPCs) that are readily absorbed by the skin. Decontamination using solvents or surfactants may modify the cornified layer - the skin's main barrier against xenobiotic penetratio...

journal_title：Toxicology letters

authors： Mircioiu C,Voicu VA,Ionescu M,Miron DS,Radulescu FS,Nicolescu AC

更新日期：2013-05-23 00:00:00

abstract：:In order to elucidate the mechanisms by which long-term treatment with clobazam (CLB), 1,5-benzodiazepine, induces thyroid follicular cell tumors in male rats, male Sprague-Dawley (SD) rats were treated orally with 400 mg/kg of CLB for up to 4 weeks, and the contribution of feedback through elevated thyroid stimulatin...

journal_title：Toxicology letters

authors： Miyawaki I,Moriyasu M,Funabashi H,Yasuba M,Matsuoka N

更新日期：2003-12-10 00:00:00