Mercury concentrations in brain and kidney following ethylmercury, methylmercury and Thimerosal administration to neonatal mice.

abstract：:New findings on Bisphenol A (BPA) contents in thermal printing papers, and receipts, in g/kg concentrations and on its dermal uptake (up to 60%) prompted us to assess the risk arising from dermal exposure. Using physiologically based toxicokinetic modelling, we simulated concentrations in blood, in liver and kidney, t...

journal_title：Toxicology letters

authors： Mielke H,Partosch F,Gundert-Remy U

更新日期：2011-07-28 00:00:00

abstract：:Mechanisms of zinc (Zn) toxicity are incompletely understood and data regarding potential endocrine alterations in Zn toxicity are scarce. To examine mechanisms of Zn toxicity, day-old chicks were pair-fed diets containing 5280 ppm (Hz) or 73 ppm (CON) Zn. Impaired postnatal growth, independent of feed consumption, an...

journal_title：Toxicology letters

authors： Dean CE,Hargis BM,Hargis PS

更新日期：1991-08-01 00:00:00

abstract：:Several pesticides used as herbicides, insecticides and fungicides are known to be endocrine disrupting chemicals (EDCs). In three pair-matched studies we found changes in sex hormone concentrations and T-lymphocytes in relation to acute and chronic pesticide exposure. After acute exposure, 1 day later the concentrati...

journal_title：Toxicology letters

authors： Straube E,Straube W,Krüger E,Bradatsch M,Jacob-Meisel M,Rose HJ

更新日期：1999-06-30 00:00:00

abstract：:The risk of lung and urinary bladder cancers was reported to be increased in individuals who carried high risk genotypes in either cytochrome P450 (CYP)1A1, CYP2E1 or glutathione S-transferase (GST)M1, and the combined genotype of both CYP1A1 and GSTM1 enzymes have an enhanced tendency of risk to lung cancer more sign...

journal_title：Toxicology letters

authors： Watanabe M

更新日期：1998-12-28 00:00:00

abstract：:It is well known that the oral administration of di-2-ethylhexyl phthalate (DEHP) produces severe seminiferous tubular atrophy in rats, but mice are far less sensitive. In the present experiment, we demonstrated that one strain of mice derived from ICR mice, Crj:CD-1, was very sensitive to DEHP-induced testicular inju...

journal_title：Toxicology letters

authors： Oishi S

更新日期：1993-01-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN) and depletion of striatal dopamine (DA), leading to a range of motor symptoms, including resting tremor, rigidity, bradykinesia and postural abnormalities. The neurotoxin (MPTP) and its active metabol...

journal_title：Toxicology letters

authors： Bernstein AI,O'Malley KL

更新日期：2013-05-23 00:00:00

abstract：:Iron is a unique poison because it is not a xenobiotic. It is an essential element and highly reactive. Because of the critical dependence upon iron and its potential to damage tissues, elaborate mechanisms have evolved for its efficient absorption, transport, cellular uptake, storage and conservation. These are incom...

journal_title：Toxicology letters

authors： Tenenbein M

更新日期：1998-12-28 00:00:00

abstract：:In present study, we compared for the first time the cytotoxicities of the 16 priority polycyclic aromatic hydrocarbons (PAHs) in human pulmonary alveolar epithelial cells HPAEpiC. Moreover, we examined the effects of each PAH on oxidative stress (SOD, GSH, and ROS), cell viability, extracellular LDH, and apoptosis. T...

journal_title：Toxicology letters

authors： Ke S,Liu Q,Yao Y,Zhang X,Sui G

更新日期：2018-06-15 00:00:00

abstract：:Lead is a toxic heavy metal with many recognized adverse health side effects. The central nervous system is the main target of lead toxicity. Although many studies on lead toxicity were conducted, the mechanism of lead toxicity remains uncertain. One possible attribution is the immature blood-brain barrier that causes...

journal_title：Toxicology letters

authors： Yang Y,Zhang X,Fu Y,Yang H

更新日期：2014-06-16 00:00:00

abstract：:Pyrethroids are neurotoxic insecticides showing significant selective toxicity on insects over mammals, but effects on mammalian nervous system are not negligible. These substances act on the voltage-gated sodium channel, prolonging the duration of the open state. The present study focused on the effect of the pyrethr...

journal_title：Toxicology letters

authors： Varró P,Kovács M,Világi I

更新日期：2017-02-05 00:00:00

abstract：:Cadmium is a carcinogenic metal known to increase the expression of several protooncogenes in a variety of cells. although the underlying mechanisms are unknown. Renal mesangial cells are smooth muscle cells in which Ca2+ signaling pathways regulate the induction of c-fos through both cAMP-dependent and mitogen-activa...

journal_title：Toxicology letters

authors： Templeton DM,Wang Z,Miralem T

更新日期：1998-03-16 00:00:00

abstract：:A partially purified toxin fraction and lantadene A were obtained from Lantana camara L. leaves by batch extraction, column chromatography and fractional crystallization. Toxicity was tested in guinea pigs. The total number of chemical entities in the partially purified toxin preparation was 7, the 2 major ones being ...

journal_title：Toxicology letters

authors： Sharma OP,Dawra RK,Makkar HP

更新日期：1987-07-01 00:00:00

abstract：:The chromosome damage induced by carboplatin (CBDCA) was evaluated in vitro. In human lymphocytes 5 micrograms/ml CBDCA produced a 7-fold increase in the frequency of sister chromatid exchanges (SCE) and a 3-fold increase in the number of cells with structural abnormalities compared with the control. Likewise, at this...

journal_title：Toxicology letters

authors： González Cid M,Mudry M,Larripa I

更新日期：1995-03-01 00:00:00

abstract：:In this study, the effects of exposure to a 900 megahertz (MHz) electromagnetic field (EMF) on serum thyroid stimulating hormone (TSH) and triiodothronine-thyroxin (T3-T4) hormones levels of adult male Sprague-Dawley rats were studied. Thirty rats were used in three independent groups, 10 of which were control (withou...

journal_title：Toxicology letters

authors： Koyu A,Cesur G,Ozguner F,Akdogan M,Mollaoglu H,Ozen S

更新日期：2005-07-04 00:00:00

abstract：BACKGROUND:GAPDH, well known for its house-keeping functions, has also been shown to be involved in cell injury, apoptosis and death under conditions of stress such as starvation, chemical injury and oxidative stress. This study examines the effect of GAPDH knockdown on cell injury in response to Rotenone. METHODS:GAP...

journal_title：Toxicology letters

authors： Liang S,Figtree G,Aiqun M,Ping Z

更新日期：2015-05-05 00:00:00

abstract：:Cataract is the leading cause of blindness with an estimated 16 million people affected worldwide. d-galactose (d-gal) is a reducing sugar that widely distributed in foodstuffs, and studies show that d-gal could promote cataract formation by damaging nature lens epithelial cells (LECs). However, the underlying mechani...

journal_title：Toxicology letters

authors： Xu Y,Li Y,Ma L,Xin G,Wei Z,Zeng Z,Xing Z,Li S,Niu H,Huang W

更新日期：2018-06-01 00:00:00

abstract：:Fusarenon-X (FX), a type B trichothecene mycotoxin, is mainly produced by Fusarium crookwellense, which occurs naturally in agricultural commodities, such as wheat and barley. FX has been shown to exert a variety of toxic effects on multiple targets in vitro. However, the embryonic toxicity of FX in vivo remains uncle...

journal_title：Toxicology letters

authors： Sutjarit S,Nakayama SM,Ikenaka Y,Ishizuka M,Banlunara W,Rerkamnuaychoke W,Kumagai S,Poapolathep A

更新日期：2014-08-17 00:00:00

abstract：INTRODUCTION:An increased health problem in industrialised countries is the contemporary concern of public and scientific community as well. This has been attributed in part to accumulated environmental pollutants especially radioactive substances and the use of nuclear power plants worldwide. However, the outcome of c...

journal_title：Toxicology letters

authors： Elmhiri G,Gloaguen C,Grison S,Kereselidze D,Elie C,Tack K,Benderitter M,Lestaevel P,Legendre A,Souidi M

更新日期：2018-01-05 00:00:00

abstract：:The increasing industrial use of nanoparticles (NPs) has raised concerns about their impact on human health. Since aging and exposure to environmental factors are linked to the risk for developing pathologies, we address the question of TiO2 NPs toxicokinetics in the context of a realistic occupational exposure. We re...

journal_title：Toxicology letters

authors： Gaté L,Disdier C,Cosnier F,Gagnaire F,Devoy J,Saba W,Brun E,Chalansonnet M,Mabondzo A

更新日期：2017-01-04 00:00:00

abstract：:The aim of this study was to establish a methodology to analyze estrogen quinone-derived adducts, including 17β-estradiol-2,3-quinone (E2-2,3-Q) and 17β-estradiol-3,4-quinone (E2-3,4-Q), in human hemoglobin (Hb). The methodology was then used to measure the levels of these adducts in Hb derived from female breast canc...

journal_title：Toxicology letters

authors： Lin C,Hsieh WC,Chen DR,Kuo SJ,Yu WF,Hu SW,Sue HJ,Ko MH,Juan CH,Chung KS,Lin PH

更新日期：2014-03-21 00:00:00

abstract：:The effect of a single i.p. injection of 0, 20, 200, and 1000 microliter/kg carbon tetrachloride on the activity of the hepatic drug-metabolizing enzyme system was measured in the rat by a model substrate assay employing lindane (gamma-hexachlorocyclohexane) and by a battery of in vitro enzyme assays. The data in this...

journal_title：Toxicology letters

authors： Chadwick RW,Copeland MF,Carlson GP,Trela BA,Most BM

更新日期：1988-09-01 00:00:00

abstract：:Silica exposure results in an initially acute inflammatory response followed by chronic fibrotic change. The mechanism for the maintenance of silica-induced inflammation has not been understood yet. In silica-induced acute inflammation and chronic fibrosis, various mediators such as reactive oxygen species, cytokines ...

journal_title：Toxicology letters

authors： Lim Y,Kim JH,Kim KA,Chang HS,Park YM,Ahn BY,Phee YG

更新日期：1999-09-05 00:00:00

abstract：:Superparamagnetic iron oxide nanoparticles (SPION) are used as high-sensitive enhancer for magnetic resonance imaging, where they represent a promising tool for early diagnosis of destructive diseases such as rheumatoid arthritis (RA). Since we could demonstrate that professional phagocytes are activated by amino-poly...

journal_title：Toxicology letters

authors： Strehl C,Schellmann S,Maurizi L,Hofmann-Amtenbrink M,Häupl T,Hofmann H,Buttgereit F,Gaber T

更新日期：2016-03-14 00:00:00

abstract：:A diversity of chemicals cause discrete lesions in the kidney by a number of different mechanisms, and similar types of chemicals may give rise to more than one target cell injury. Screening for these lesions in vivo may be unreliable if a single noninvasive or invasive criterion is used. Instead, evidence of nephroto...

journal_title：Toxicology letters

authors： Bach PH

更新日期：1989-03-01 00:00:00

abstract：:Dysregulated cell proliferation and tumorigenesis is frequently encountered in several cancers including hepatocellular carcinogenesis (HCC). Thus, agents that inhibit cell proliferation and restrain hepatic tumorigenesis through cell cycle regulation have a beneficial effect in the treatment of hepatocellular carcino...

journal_title：Toxicology letters

authors： Raghunandhakumar S,Paramasivam A,Senthilraja S,Naveenkumar C,Asokkumar S,Binuclara J,Jagan S,Anandakumar P,Devaki T

更新日期：2013-10-23 00:00:00

abstract：:Mercury is the major component of dental amalgam restorative material, which typically has 50% pure elemental mercury. It is also used in some skin creams, and in the manufacturing of plastic, drugs and fungicides. The present study was designed to investigate the toxicity of methyl mercury (MeHg+) on isolated rat hep...

journal_title：Toxicology letters

authors： Ashour H,Abdel-Rahman M,Khodair A

更新日期：1993-07-01 00:00:00

abstract：:Sulfur dioxide (SO2) is a ubiquitous air pollutant, presents in low concentrations in the urban air, and in higher concentrations in the working environment. In the present study, male Wistar rats were housed in exposure chambers and treated with 14.00+/-1.53, 28.00+/-2.12 and 56.00+/-4.28 mg/m3 SO2 for 6 h/day for 7 ...

journal_title：Toxicology letters

authors： Qin G,Meng Z

更新日期：2005-12-30 00:00:00

abstract：:7-Methyldeoxyguanosine (7-medG) may be a useful marker of human exposure to methylating agents at the individual level. Methods of detection, including 32P-postlabeling, HPLC with electrochemical or fluorescence detection, and immunoassays, are critically summarized. These methods have been applied to the analysis of ...

journal_title：Toxicology letters

authors： Bianchini F,Wild CP

更新日期：1994-06-01 00:00:00

abstract：:The effect of dietary vomitoxin on the serum IgA and IgG responses to two model intestinal antigens, casein and cholera toxin (CT), were assessed in 4 experimental groups: (1) mice fed casein-based diet, (2) mice fed casein-based diet containing 25 ppm vomitoxin, (3) mice fed casein-based diet and immunized with CT, a...

journal_title：Toxicology letters

authors： Pestka JJ,Moorman MA,Warner RL

更新日期：1990-01-01 00:00:00

abstract：:The skin is an immunologically active tissue. Epidermal cells, both keratinocytes and Langerhans cells (LC), produce constitutively or can be stimulated to produce a variety of cytokines, many of which play important roles in the induction and regulation of allergic responses to sensitizing chemicals. Tumor necrosis f...

journal_title：Toxicology letters

authors： Kimber I,Holliday MR,Dearman RJ

更新日期：1995-12-01 00:00:00