Abstract：
:Using equimolar quantities of 2 chemical allergens, toluene diisocyanate (TDI), noted for its ability to cause respiratory hypersensitivity, and dinitrochlorobenzene (DNCB), noted for its dermal sensitizing activity, the mouse was evaluated as a possible model to indicate respiratory hypersensitivity. A previously published procedure (Garssen et al. (1989) Immunology 68, 51-58) was followed whereby chemicals were applied epicutaneously to the shaved flank of BALB/c mice. Eight days later, animals were challenged by intranasal application of the chemical. The lungs were evaluated at 48 h. Both TDI and DNCB elicited mild mononuclear inflammatory cuffing around pulmonary vasculature. No reaction was noted around pulmonary airways. Sera, drawn 48 h following the intranasal challenge with chemical allergen, were evaluated for total IgE, hapten-specific IgE and IgG, and for IL-2, IL-4, IL-5, IL-6, and interferon gamma. Animals exposed to TDI demonstrated decreased total IgE and the presence of TDI-specific IgG. Cytokine levels were unchanged in both groups. These results indicate that in this mouse model, total serum IgE and the production of hapten-specific IgG antibodies distinguished a respiratory from a contact sensitizing chemical. Further comparison of the serologic response of mice to these two classes of chemicals is required to determine if the murine model can be used to predict dermal versus respiratory sensitizing activity of chemical allergens.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Satoh T,Kramarik JA,Tollerud DJ,Karol MHdoi
10.1016/0378-4274(94)03234-xsubject
Has Abstractpub_date
1995-06-01 00:00:00pages
57-66issue
1eissn
0378-4274issn
1879-3169pii
037842749403234Xjournal_volume
78pub_type
杂志文章abstract：:Nephrotoxicity limits the therapeutic efficacy of the antineoplastic drug cisplatin. Due to dosage adjustment and appropriate monitoring, most therapeutic courses with cisplatin produce no or minimal kidney damage. However, we studied whether even sub-nephrotoxic dosage of cisplatin poses a potential risk for the kidn...
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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doi：10.1016/j.toxlet.2008.07.005
更新日期：2008-09-26 00:00:00
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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pub_type： 杂志文章
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更新日期：2011-01-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2018-12-01 00:00:00
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journal_title：Toxicology letters
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更新日期：2009-02-25 00:00:00
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journal_title：Toxicology letters
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更新日期：2017-11-05 00:00:00
abstract：:Long-term (20 days) treatment with methyl mercury (MeHg) increases the total number of benzodiazepine binding sites and decreases essentially the content of cyclic GMP in the cerebellar cortex. In contrast, this treatment fails to modify the content of GABA and cyclic AMP, GAD activity and GABA binding sites in the sa...
journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1983-08-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.03.004
更新日期：2014-05-16 00:00:00
abstract：:On chronic administration of 20 microliter of chilli extract to the cheek pouch of hamsters till death, 23% of the hamsters developed shrunken eye balls and closing of the eyelids. This effect was not observed in hamsters which received a single application of the potent carcinogen methylacetoxymethyl nitrosamine (DMN...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(85)90002-5
更新日期：1985-10-01 00:00:00
