Inhibition of human and rat CYP1A1 enzyme by grapefruit juice compounds.

abstract：:The target cell(s) of theobromine toxicity on rat testes and reproductive toxicity induced by pure theobromine and cocoa extract are evaluated in the present studies. Theobromine (500 mg/kg x 7 days) inhibited body weight gain in treated rats. Decreased cauda epididymal sperm reserve (38%), seminiferous tubule fluid (...

journal_title：Toxicology letters

authors： Wang Y,Waller DP

更新日期：1994-02-01 00:00:00

abstract：:The HER2 pathway plays a pivotal role in cell proliferation and differentiation, while the receptor overexpression caused by amplification of HER2 gene is associated with the growth of several tumors. Previously published clinical trials have demonstrated that antibody-conjugated drugs (ADCs) remarkably improved clini...

journal_title：Toxicology letters

authors： Jiang J,Li S,Shan X,Wang L,Ma J,Huang M,Dong L,Chen F

更新日期：2020-05-15 00:00:00

abstract：:In connection with extensive health studies of employees from two big central waste disposal sites, cytogenetic investigations were performed. The subject of these special analyses was to examine whether the complex mixture of pollutants from waste disposal sites comprises a genotoxic hazardous potential. Cytogenetic ...

journal_title：Toxicology letters

authors： Fender H,Wolf G

更新日期：1998-08-01 00:00:00

abstract：:The color additive, amaranth, was given in the diet to provide dietary levels of 0 (control), 0.03, 0.09 and 0.27%, from 5 weeks of age in F0 generation mice to 9 weeks of age in F1 generation mice, and some reproductive, developmental and behavioral parameters were measured. There was no effect on the parameters of l...

journal_title：Toxicology letters

authors： Tanaka T

更新日期：1992-05-01 00:00:00

abstract：:Bisphenol A (BPA) is a potential endocrine disruptor. It has been shown that it can interfere with steroid biosynthesis and metabolism. However, the mechanism is unclear. The objective of the present study is to investigate the effects of BPA on two isoforms of 11β-hydroxysteroid dehydrogenases (11β-HSD1 and 11β-HSD2)...

journal_title：Toxicology letters

authors： Guo J,Yuan X,Qiu L,Zhu W,Wang C,Hu G,Chu Y,Ye L,Xu Y,Ge RS

更新日期：2012-11-30 00:00:00

abstract：:Between 1997 and 2011, more than 200 new substances were notified through the early-warning system, with the record number of 49 novel molecules reported in 2011. The pattern of acute toxicity associated with the consumption of these new substances is generally similar to that seen with traditional drugs of abuse. Rec...

journal_title：Toxicology letters

authors： Coppola M,Mondola R

更新日期：2012-07-07 00:00:00

abstract：:Various hypotheses on the origin of cancer stem cells (CSCs) exist, including that CSCs develop from transformed human bone marrow mesenchymal stem cells (hBMSC). Since the polyether antibiotic salinomycin selectively kills CSCs, the present study aims to elucidate the effects of salinomycin on normal hBMSC. The immun...

journal_title：Toxicology letters

authors： Scherzed A,Hackenberg S,Froelich K,Rak K,Technau A,Radeloff A,Nöth U,Koehler C,Hagen R,Kleinsasser N

更新日期：2013-04-26 00:00:00

abstract：:In recent years physiologically based pharmacokinetic (PBPK) modeling has found frequent application in risk assessments where PBPK models serve as important adjuncts to studies on modes of action of xenobiotics. In this regard, studies on mode of action provide insight into both the sites/mechanisms of action and the...

journal_title：Toxicology letters

authors： Andersen ME

更新日期：2003-02-18 00:00:00

abstract：:Di-(2-ethylhexyl)-phthalate (DEHP) is a phthalate ester that binds peroxisome proliferator-activated receptor α (PPARα) to induce proliferation of peroxisomes and regulate the expression of specific target genes. The question of whether the effect of DEHP on female reproductive processes is mediated via PPARα-dependen...

journal_title：Toxicology letters

authors： Kawano M,Qin XY,Yoshida M,Fukuda T,Nansai H,Hayashi Y,Nakajima T,Sone H

更新日期：2014-08-04 00:00:00

abstract：:The genotoxicity of cypermethrin, a synthetic pyrethroid insecticide, has been studied in vivo in mice. Bone marrow chromosome aberrations were not dose, time or route dependent, but most of the results differed significantly from controls except after 6 and 24 h of treatment using the i.p. and s.c. routes, respective...

journal_title：Toxicology letters

authors： Bhunya SP,Pati PC

更新日期：1988-06-01 00:00:00

abstract：:Iron plays a critical role in a mammal's physiological processes. However, iron tissue deposits have been shown to act as endocrine disrupters. Studies that evaluate the effect of acute iron overload on hypothalamic-pituitary-gonadal (HPG) axis health are particularly sparse. This study demonstrates that acute iron ov...

journal_title：Toxicology letters

authors： Rossi EM,Marques VB,Nunes Dde O,Carneiro MT,Podratz PL,Merlo E,dos Santos L,Graceli JB

更新日期：2016-01-05 00:00:00

abstract：:The behavioral effects of concurrent maternal exposure to restraint stress and perfluorooctane sulfonate (PFOS) were assessed in the offspring of mice at 3 months of age. Plug positive females were divided into two groups. Animals were given by gavage 0 and 6mg PFOS/kg/day on gestation days 12-18. One-half of the anim...

journal_title：Toxicology letters

authors： Fuentes S,Colomina MT,Vicens P,Domingo JL

更新日期：2007-07-10 00:00:00

abstract：:The hedgehog (HH) signaling pathway plays an important role in lung development, but its significance in silicosis is unclear. We showed that in human coal pneumoconiosis autopsy specimens, Sonic Hedgehog (SHH) and the Glioma-associated oncogene homolog transcription factors family (GLI) 1 proteins were up-regulated, ...

journal_title：Toxicology letters

authors： Zhang B,Xu H,Zhang Y,Yi X,Zhang G,Zhang X,Xu D,Gao X,Li S,Zhu Y,Zhang H,Wei Z,Li S,Zhang L,Wang R,Yang F

更新日期：2019-10-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN) and depletion of striatal dopamine (DA), leading to a range of motor symptoms, including resting tremor, rigidity, bradykinesia and postural abnormalities. The neurotoxin (MPTP) and its active metabol...

journal_title：Toxicology letters

authors： Bernstein AI,O'Malley KL

更新日期：2013-05-23 00:00:00

abstract：:The phthalates di(2-ethylhexyl)phthalate (DEHP) and di-n-butyl phthalate (DBP) are environmental contaminants with significant human exposures. Both compounds are known reproductive toxins in rodents and DEHP also induces rodent hepatocarcinogenesis in a process believed to be mediated via the peroxisome proliferator-...

journal_title：Toxicology letters

authors： Venkata NG,Robinson JA,Cabot PJ,Davis B,Monteith GR,Roberts-Thomson SJ

更新日期：2006-06-01 00:00:00

abstract：:Ethyl glucuronide (EtG) is an ethanol metabolite and EtG is used as a biomarker of alcohol drinking. EtG can be detected in the blood and in several biological matrices including urine, hair and nails. Alcohol consumption during pregnancy is a strong risk factor for fetus health so in the recent years different strate...

journal_title：Toxicology letters

authors： Ferraguti G,Ciolli P,Carito V,Battagliese G,Mancinelli R,Ciafrè S,Tirassa P,Ciccarelli R,Cipriani A,Messina MP,Fiore M,Ceccanti M

更新日期：2017-06-05 00:00:00

abstract：:Fe(3)O(4) magnetic nanoparticles (MNPs) coated with 2,3-dimercaptosuccinnic acid (DMSA) are considered to be a promising nanomaterial with biocompatibility. In the present study, the effects of DMSA-coated Fe(3)O(4) MNPs on the expression of all identified mouse genes, which regulate various cellular biological proces...

journal_title：Toxicology letters

authors： Liu Y,Chen Z,Gu N,Wang J

更新日期：2011-08-28 00:00:00

abstract：:Both arsenite and benzo(a)pyrene (BaP) are known human carcinogens. Studies on the mode-of-action of arsenite indicate that it can also act as co-carcinogen or as a cancer promoter, and that it can facilitate progression of cancers. Some studies on development of lung cancers have suggested a synergism between arsenit...

journal_title：Toxicology letters

authors： Pang Y,Xu Y,Li H,Li Y,Zhao Y,Jiang R,Shen L,Zhou J,Wang X,Liu Q

更新日期：2013-04-12 00:00:00

abstract：:The hepatotoxic effects of the oral administration of a single dose of 50 mg dimethylnitrosamine (DMN)/kg and daily doses of 5 mg and 1 mg/kg, respectively, to cats and lizards were studied by light microscopy. Centrilobular necrosis was the main alteration detected in the liver of cats as in other animal species stud...

journal_title：Toxicology letters

authors： Maduagwu EN,Anosa VO

更新日期：1981-09-01 00:00:00

abstract：:Fenvalerate (Fen), widely used for its high insecticidal potency and low mammalian toxicity, is classified as an endocrine-disrupting chemical. Recently, Fen has received great attention for its adverse effects on human reproductive health. In this study, we found that Fen (10 microM) had a stimulatory effect on the g...

journal_title：Toxicology letters

authors： Gao X,Yu L,Castro L,Moore AB,Hermon T,Bortner C,Sifre M,Dixon D

更新日期：2010-07-15 00:00:00

abstract：:7-Methyldeoxyguanosine (7-medG) may be a useful marker of human exposure to methylating agents at the individual level. Methods of detection, including 32P-postlabeling, HPLC with electrochemical or fluorescence detection, and immunoassays, are critically summarized. These methods have been applied to the analysis of ...

journal_title：Toxicology letters

authors： Bianchini F,Wild CP

更新日期：1994-06-01 00:00:00

abstract：:Stoichiometric conversion of methyl acetate to methanol in vitro was detected when methyl acetate was incubated with blood for 2 to 8 h. The velocity of the reaction was so fast that almost all of methyl acetate disappeared in 8 h. The methanol formation was further confirmed by means of gas-chromatography-mass spectr...

journal_title：Toxicology letters

authors： Mizunuma K,Kawai T,Yasugi T,Horiguchi S,Iwami O,Ikeda M

更新日期：1992-09-01 00:00:00

abstract：:The oral LD50 of hymenoxon in Swiss white mice was found to be 241 +/- 37 mg/kg. No significant sex differences were observed. Pretreatment of male mice for 3 days using doses of 50 and 100 mg/kg hymenoxon failed to alter significantly pentobarbital sleeping time. Hymenoxon was found to be a direct-acting mutagen in t...

journal_title：Toxicology letters

authors： Jones DH,Kim HL

更新日期：1981-12-01 00:00:00

abstract：:The effect of melatonin on potassium cyanide-induced neurotoxicity was investigated in vivo. The ED50 value of potassium cyanide, as measured by induction of tonic and clonic seizures, was significantly increased by 1.5- or 1.8-fold by s.c. preinjection of melatonin (20, 100 or 345 mg/kg) in mice. The preventive effec...

journal_title：Toxicology letters

authors： Yamamoto H,Tang HW

更新日期：1996-09-01 00:00:00

abstract：:Subchronic oral toxicity of turmeric and ethanolic turmeric extract was studied in female Swiss mice and Wistar rats fed turmeric (0, 1 and 5%) and ethanolic turmeric extract (0, 0.05 and 0.25%) through diet for 14 and/or 90 days. The administration of a high dose of turmeric (5%) for longer duration (90 days) showed ...

journal_title：Toxicology letters

authors： Deshpande SS,Lalitha VS,Ingle AD,Raste AS,Gadre SG,Maru GB

更新日期：1998-05-01 00:00:00

abstract：:The development of novel alternative testing methods is required to identify the sensitizing capacity of chemicals as a replacement for animal experimentation. We aimed to evaluate in vitro assays as screening tools for detecting skin sensitizers. The murine epidermal keratinocyte cell line HEL-30 was exposed to 16 re...

journal_title：Toxicology letters

authors： Son D,Na Y,Cho WS,Lee BH,Heo Y,Park JH,Seok SH

更新日期：2013-01-10 00:00:00

abstract：:Ethanolamine, a positively charged hydrophilic component of the phosphatidylethanolamine (PE) which is also a precursor of phosphatidylcholine (PC), enhances the repair processes 24 h after carbon tetrachloride (CCl4) intoxication of mouse liver. Ethanolamine quickly reduced aminotransferase activity released in the s...

journal_title：Toxicology letters

authors： Murakami T,Nagamura Y,Hirano K

更新日期：1998-01-31 00:00:00

abstract：:Evaluating myelotoxicity is essential for ensuring the safety of novel drugs before they are approved for clinical applications. Although in vivo prediction of the maximum tolerated doses (MTDs) of anticancer drugs is usually performed in rodents, the results are not always applicable to clinical treatment because dru...

journal_title：Toxicology letters

authors： Ito R,Nagai D,Igo N,Okuda Y,Sekine K,Ichimura E,Katano I,Mizushima T,Goto M,Ohnishi Y,Ito M,Okamoto K

更新日期：2017-11-05 00:00:00

abstract：:In recent years, concern about possible female reproductive and developmental toxicity due to environmental contaminants, such as PCBs, has been growing. Because this area of toxicology had not been emphasized prior to this time, there are many gaps in current knowledge about female developmental and reproductive toxi...

journal_title：Toxicology letters

authors： Kamrin MA,Carney EW,Chou K,Cummings A,Dostal LA,Harris C,Henck JW,Loch-Caruso R,Miller RK

更新日期：1994-11-01 00:00:00

abstract：:Lithocholic acid (LCA) supplementation in the diet results in intrahepatic cholestasis and bile infarcts. Previously we showed that an innate immune response is critical for cholestatic liver injury in the bile duct ligated mice. Thus, the purpose of this study was to investigate the role of neutrophils in the mechani...

journal_title：Toxicology letters

authors： Woolbright BL,Li F,Xie Y,Farhood A,Fickert P,Trauner M,Jaeschke H

更新日期：2014-07-03 00:00:00