Effects of 900 MHz electromagnetic field on TSH and thyroid hormones in rats.

abstract：BACKGROUND:The epithelial to mesenchymal transition (EMT) contributes to fibrosis during silicosis. Zinc finger CCCH-type containing 4 protein (ZC3H4) is a novel CCCH-type zinc finger protein that activates inflammation in pulmonary macrophages during silicosis. However, whether ZC3H4 is involved in EMT during silicosi...

journal_title：Toxicology letters

authors： Jiang R,Zhou Z,Liao Y,Yang F,Cheng Y,Huang J,Wang J,Chen H,Zhu T,Chao J

更新日期：2019-06-01 00:00:00

abstract：:Fumonisin B1 (FB1) and beauvericin (BEA) are secondary metabolites of filamentous fungi, which under appropriate temperature and humidity conditions may develop on various foods and feeds. To date few studies have been performed to evaluate the toxicological and endocrine disrupting effects of FB1 and BEA. The present...

journal_title：Toxicology letters

authors： Fernández-Blanco C,Frizzell C,Shannon M,Ruiz MJ,Connolly L

更新日期：2016-08-22 00:00:00

abstract：:Exposure to high levels of persistent pollutants, such as metal mixtures, is commonly encountered by the general population especially in industrialized countries. The aim of this work was to evaluate how metal pollution in contaminated areas is reflected in terms of biomarkers (BMs) of exposure and effect in human su...

journal_title：Toxicology letters

authors： de Andrade VL,Cota M,Serrazina D,Mateus ML,Aschner M,Dos Santos APM

更新日期：2020-05-15 00:00:00

abstract：:N-cadherin has known to be involved in tumor progression and metastasis. However, it is still obscure about the signaling pathway involving in the processing of N-cadherin. Thus, we examined which signaling pathway plays a major role in the processing of N-cadherin in C6 glioma cells following treatment of cadmium (Cd...

journal_title：Toxicology letters

authors： Jo C,Koh YH

更新日期：2013-10-24 00:00:00

abstract：:By the gas plant at Schwaan (a small city near Rostock), tar and other by-products were released into the river Warnow which supplies Rostock with drinking water 20 km downstream. The tar-contaminated river sediment contained phenols and polycyclic aromatic hydrocarbons (PAH), indicating a mutagenic potential. Investi...

journal_title：Toxicology letters

authors： Randow FF,Hübener T,Merkel G

更新日期：1996-11-01 00:00:00

abstract：:Rats (Fisher, Wistar, Donryu and Sprague-Dawley strains) were exposed to 5 approximately 3500 ppm toluene for 8 h, and urine samples were analyzed for hippuric acid and cresols. While hippuric acid increased in proportion to the exposure concentration, a sharp increase in o-cresol excretion was observed at high toluen...

journal_title：Toxicology letters

authors： Inoue O,Seiji K,Ishihara N,Kumai M,Ikeda M

更新日期：1984-11-01 00:00:00

abstract：:Since guanidinoacetic acid (GAA), a precursor of creatine, is synthesized mainly in the proximal tubule of the kidney where gentamicin (GM) nephrotoxicity often occurs, GM-induced renal cell damage was investigated using GAA synthesis in tubular suspension as an indicator. Results obtained were as follows: (1) GAA syn...

journal_title：Toxicology letters

authors： Takeda M,Jung KY,Sekine T,Endou H,Koide H

更新日期：1995-11-15 00:00:00

abstract：:Accumulation of macrophages and neutrophil granulocytes in the lung are key events in the inflammatory response to inhaled particles. The present study aims at the time course of chemotaxis in vitro in response to the challenge of various biopersistent particles and its functional relation to the transcription of infl...

journal_title：Toxicology letters

authors： Schremmer I,Brik A,Weber DG,Rosenkranz N,Rostek A,Loza K,Brüning T,Johnen G,Epple M,Bünger J,Westphal GA

更新日期：2016-11-30 00:00:00

abstract：:Haemolysis by chrysotile fibres may be related to an adsorption of the red blood cell (RBC) membranes on the fibres and not to an interaction between magnesium (Mg) from the fibres and sialic acid from RBC. This was demonstrated using neuraminidase (NANASE)-treated RBC and Mg-depleted chrysotile fibres. The mechanism ...

journal_title：Toxicology letters

authors： Jaurand MC,Magne L,Bignon J

更新日期：1983-02-01 00:00:00

abstract：:The effect of copper (Cu) deficiency on antioxidant status of liver and heart and its effect on adriamycin toxicity was assessed. Weanling rats were fed Cu-adequate (+Cu) and Cu-deficient (-Cu) diets for 3 weeks and then injected intraperitoneally once with saline or adriamycin (8 mg/kg). All -Cu rats had increased he...

journal_title：Toxicology letters

authors： Fischer J,Johnson MA,Tackett RL

更新日期：1991-07-01 00:00:00

abstract：:The direct or indirect interference with GABA-mediated neurotransmission results in convulsive seizure activity in humans and experimental animals. When this convulsant effect is experimentally analyzed, it turns out to be a product of discrete and restricted cerebral sites of drug action. Depending upon the brain cir...

journal_title：Toxicology letters

authors： Gale K

更新日期：1992-12-01 00:00:00

abstract：:Cynomolgus monkeys showed no measurable adverse effects following inhalation of 500 ppm dimethylformamide (DMF), 6 h/d, 5 d/wk, for 2 weeks either when exposed whole-body or head-only (one monkey per exposure route). Measurement of DMF concentrations into and out of the head-only exposure unit along with measurement o...

journal_title：Toxicology letters

authors： Hurtt ME,McCooey KT,Placke ME,Kennedy GL

更新日期：1991-12-01 00:00:00

abstract：:In recent years, concern about possible female reproductive and developmental toxicity due to environmental contaminants, such as PCBs, has been growing. Because this area of toxicology had not been emphasized prior to this time, there are many gaps in current knowledge about female developmental and reproductive toxi...

journal_title：Toxicology letters

authors： Kamrin MA,Carney EW,Chou K,Cummings A,Dostal LA,Harris C,Henck JW,Loch-Caruso R,Miller RK

更新日期：1994-11-01 00:00:00

abstract：:Evaluating myelotoxicity is essential for ensuring the safety of novel drugs before they are approved for clinical applications. Although in vivo prediction of the maximum tolerated doses (MTDs) of anticancer drugs is usually performed in rodents, the results are not always applicable to clinical treatment because dru...

journal_title：Toxicology letters

authors： Ito R,Nagai D,Igo N,Okuda Y,Sekine K,Ichimura E,Katano I,Mizushima T,Goto M,Ohnishi Y,Ito M,Okamoto K

更新日期：2017-11-05 00:00:00

abstract：:The prevention of renal diseases induced by chemicals requires the use of tests with which adverse renal effects can be detected at a stage when removal from exposure to the offending agent(s) may lead to complete recovery or may at least prevent an accelerated decline in renal function. The screening tests used in cl...

journal_title：Toxicology letters

authors： Lauwerys R,Bernard A

更新日期：1989-03-01 00:00:00

abstract：:Whole-body inhalation exposures to N,N-dimethylacetamide (DMAC) were conducted with male rats (Crl:CD BR) and mice (Crl:CD-1 (ICR)BR). Exposure concentrations were 50, 150, 300 and 500 ppm. The exposure routines consisted of single 1-, 3-, or 6-h exposures and ten 6-h exposures (10 exposure days in 2 weeks). Area unde...

journal_title：Toxicology letters

authors： Hundley SG,Lieder PH,Valentine R,McCooey KT,Kennedy GL Jr

更新日期：1994-09-01 00:00:00

abstract：:Benzidine dihydrochloride administered in water at 0, 30, 60, 120, 200 or 400 ppm to 1664 mice induced a total of 368 hepatocellular carcinomas, of which 34 or 9.2% metastasized to the lungs. Liver tumors which were larger and heavier were more prone to metastasize and all that metastasized contained areas of prominen...

journal_title：Toxicology letters

authors： Frith CH,Baetcke KP,Nelson CJ,Schieferstein G

更新日期：1980-12-01 00:00:00

abstract：:Perfluorooctanoic acid (PFOA) is a stable man-made compound with many industrial and commercial uses. Recently, however, concern has been raised that it may induce various toxicological effects such as hepatotoxicity, immunotoxicity, and developmental toxicity. Because levels of circulating microRNAs (miRNAs) can be a...

journal_title：Toxicology letters

authors： Yan S,Wang J,Zhang W,Dai J

更新日期：2014-01-03 00:00:00

abstract：:A single intravenous injection of 4-hydroxyaminoquinoline 1-oxide in a dose of 9 mg/kg induced exocrine adenomas of the pancreas in a significantly higher rate in male than in female rats. Castration following HAQO administration diminished the incidence of the pancreatic tumors in male rats. A combined treatment with...

journal_title：Toxicology letters

authors： Hayashi Y,Katayama H

更新日期：1981-12-01 00:00:00

abstract：:A quantitative high-content screening (HCS) was suggested for the real-time monitoring of drug-induced mitochondrial dysfunction-mediated hepatotoxicity. This HCS is very advantageous in that it allows simultaneous observation of drug-induced activations of hepatotoxic pathways using hypermulticolor cellular imaging. ...

journal_title：Toxicology letters

authors： Kim JA,Han E,Eun CJ,Tak YK,Song JM

更新日期：2012-10-17 00:00:00

abstract：:In this subacute toxicity study, ethyl methanesulfonate (EMS) was administered daily by oral gavage to SPF-bred Wistar rats of both sexes at dose levels of 20, 60 and 180/120 mg/kg body weight (bw)/day for a period of 28 days (for 19 days in the high-dose group). A control group was treated similarly with the vehicle,...

journal_title：Toxicology letters

authors： Pfister T,Eichinger-Chapelon A

更新日期：2009-11-12 00:00:00

abstract：:Rat and canine hepatocyte suspensions were exposed to toxic concentrations of ethyl methanesulfonate (EMS) and ionophore A-23187 in the presence and absence of extracellular calcium (Ca2+) and alpha-tocopheryl succinate (alpha-TS). The exogenous administration of alpha-TS (25 microM) completely protected hepatocytes f...

journal_title：Toxicology letters

authors： Fariss MW,Merson MH,O'Hara TM

更新日期：1989-04-01 00:00:00

abstract：:Hydrochlorofluorocarbon 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123), a close structural analogue of the hepatotoxic anaesthetic halotane and a replacement for some ozone-depleting chlorofluorocarbons, is metabolized by liver cytochrome P450 (P450), both in vitro and in vivo. P450 activates HCFC-123, both oxidatively...

journal_title：Toxicology letters

authors： Zanovello A,Ferrara R,Manno M

更新日期：2003-09-15 00:00:00

abstract：:To characterize the accumulated hazards associated with the inhalation of gases typical of combustion products, a time-integrated value known as the fractional effective dose (FED) is used. This FED is maintained by the International Organization for Standardization (ISO) and made publicly available as the Standard IS...

journal_title：Toxicology letters

authors： Pauluhn J

更新日期：2016-11-16 00:00:00

abstract：:The European Commission has decided on harmonized classifications for a large number of individual chemicals according to its own directive for classification and labeling of dangerous substances. We have compared the harmonized classifications for acute oral toxicity to the acute oral toxicity data available in the R...

journal_title：Toxicology letters

authors： Rudén C,Hansson SO

更新日期：2003-09-30 00:00:00

abstract：:In the present study, the emetic effect of the anticancer drug cisplatin, and protective effects of 5-HT3 receptor antagonists against cisplatin emesis were investigated in the pigeon. The experimental setting involved the i.v. administration of drugs and subsequent observation of the percentage of vomiting animals an...

journal_title：Toxicology letters

authors： Navarra P,Martire M,del Carmine R,Pozzoli G,Preziosi P

更新日期：1992-12-01 00:00:00

abstract：:Isolated rat hepatocytes incubated aerobically formed measurable amounts of ethane, a parameter for lipid peroxidation. This ethane formation increased several-fold due to carbon tetrachloride (CCl4) depending on its concentration. Cell damage as measured by trypan blue uptake and lactate dehydrogenase release poorly ...

journal_title：Toxicology letters

authors： de Ruiter N,Ottenwälder H,Muliawan H,Kappus H

更新日期：1981-06-01 00:00:00

abstract：:Tetrachlorobenzyltoluene (TCBT) (Ugilec 141) was investigated in induction experiments in male and female Wistar rats with long-term (50, 100 and 300 mg/kg p.o. daily for 28 days) and short-term administration (300 mg/kg once and 100 mg/kg daily for 4 days). The increase in total cytochrome P-450 did not exceed the fa...

journal_title：Toxicology letters

authors： von Meyerinck L,Hufnagel B,Schmoldt A,Benthe HF

更新日期：1990-04-01 00:00:00

abstract：:To reduce the production of pollutants in motor vehicle exhaust, methyl tert-butyl ether (MTBE) and other ethers such as ethyl tert-butyl ether (ETBE) and tert-amyl methyl ether (TAME) are added to gasoline as oxygenates for more complete combustion. Metabolism of these gasoline ethers is catalyzed by cytochrome P450 ...

journal_title：Toxicology letters

authors： Hong JY,Wang YY,Bondoc FY,Yang CS,Gonzalez FJ,Pan Z,Cokonis CD,Hu WY,Bao Z

更新日期：1999-03-08 00:00:00

abstract：:Harmonisation of risk assessment (RA) is one of the priorities for sound chemical management set by Chapter 19, Agenda 21 of the United Nations Conference on the Environment and Development (UNCED) 1992 Earth Summit. The benefits of harmonisation are self evident and include transportability and consistency of RA outc...

journal_title：Toxicology letters

authors： Di Marco PN,Priestly BG,Buckett KJ

更新日期：1998-12-28 00:00:00