Molecular and kinetic determinants of local anaesthetic action on sodium channels.

abstract：:Acute effects of CHBrCl2 on microsomal lipid metabolism were studied in the liver of male Wistar rats administered a single oral dose (215 mg/kg). 3 h after administration, the modulation of phospholipid metabolism and the accumulation of triacylglycerol (TG) were noted in the microsomal membranes. A marked decrease i...

journal_title：Toxicology letters

authors： Koyama Y,Nakazawa Y

更新日期：1985-12-01 00:00:00

abstract：:Dibenz (b,f)-1-4 oxazepine (CR) was applied to the skin of C3H and Porton-strain mice, daily for 12 weeks. After a further 80 weeks the animals were sacrificed and examined grossly and histologically. The results were compared with appropriate solvent and untreated controls. No abnormalities were found that could be a...

journal_title：Toxicology letters

authors： Marrs TC,Gray MI,Colgrave HF,Gall D

更新日期：1982-10-01 00:00:00

abstract：:The effects of menadione on activities and expression of cytochrome P450 (CYP) 1A subfamily (CYP1A) isozymes in rat hepatic tissue were examined. When rats were treated orally with 15 mg/kg menadione for 4 days, the elevation of hepatic CYP1A1/1A2 specific activities in microsomal preparations was detected with approx...

journal_title：Toxicology letters

authors： Sidorova YA,Grishanova AY,Lyakhovich VV

更新日期：2005-02-15 00:00:00

abstract：:Enzymatic activities of Na+/K+-ATPase and Mg2+ -ATPase from rat brain synaptic plasma membrane were studied in the absence and presence of EDTA. The aim of the study was to examine the ability of this strong chelator to prevent and recover the CuSO4-induced inhibition. The influence of experimentally added CuSO4 and E...

journal_title：Toxicology letters

authors： Vasić V,Jovanović D,Krstić D,Nikezić G,Horvat A,Vujisić L,Nedeljković N

更新日期：1999-10-29 00:00:00

abstract：:When used in the risk assessment process, the output from physiologically based pharmacokinetic (PBPK) models has usually been considered as an exact estimate of dose, ignoring uncertainties in the parameter values used in the model and their impact on model predictions. We have collected experimental data on the vari...

journal_title：Toxicology letters

authors： Gearhart JM,Mahle DA,Greene RJ,Seckel CS,Flemming CD,Fisher JW,Clewell HJ 3rd

更新日期：1993-05-01 00:00:00

abstract：:The target cell(s) of theobromine toxicity on rat testes and reproductive toxicity induced by pure theobromine and cocoa extract are evaluated in the present studies. Theobromine (500 mg/kg x 7 days) inhibited body weight gain in treated rats. Decreased cauda epididymal sperm reserve (38%), seminiferous tubule fluid (...

journal_title：Toxicology letters

authors： Wang Y,Waller DP

更新日期：1994-02-01 00:00:00

abstract：:Breathing pattern and lung mechanical parameters were measured in 7 female Wistar rats (ca. 200 g) during exposure to 1.0 (n = 5) or 1.3 (n = 2) ppm ozone in air for 2 h and during a 2-h post-exposure observation period. Changes in breathing pattern showed a gradual decrease from 3 to 2 Hz at constant minute ventilati...

journal_title：Toxicology letters

authors： Zwart A,Arts JH

更新日期：1994-06-01 00:00:00

abstract：:Transgenic rodents that contain easily retrievable target genes allow the rapid quantitation of mutations in any tissue from which DNA can be isolated. We are using the Stratagene Big Blue transgenic mouse system that contains a lacI target and an alpha lacZ reporter gene to study the parameters that affect mutations....

journal_title：Toxicology letters

authors： Mirsalis JC

更新日期：1995-12-01 00:00:00

abstract：:Previous studies in this laboratory have demonstrated that the alpha 2-adrenergic agonist clonidine and related drugs can offer significant protection against both the acute and chronic toxicity to soman administration in rats and mice. The purpose of this study was to determine whether addition of clonidine to a stan...

journal_title：Toxicology letters

authors： Buccafusco JJ,Heithold DL,Chon SH

更新日期：1990-08-01 00:00:00

abstract：UNLABELLED:The Mre11, Rad50, and Nbs1 (MRN) complex is a DNA double-strand break sensor involved in DNA damage repair. Herein, we explored whether deletion of NAD(P)H:quinone oxidoreductase 1 (NQO1), a cytoprotective gene, affected MRN complex expression in the kidney after cisplatin-induced acute kidney injury (AKI)....

journal_title：Toxicology letters

authors： Kim YJ,Kim TW,Park SR,Kim HT,Jung DY,Ryu SY,Jung JY

更新日期：2016-01-22 00:00:00

abstract：:Upon entering the body, nerve agents can bind active amino acid residues to form phosphonylated adducts. Tabun derivatives (O-alkyl-N,N-dialkyl phosphoroamidocyanidates) have strikingly different structural features from other G-series nerve agents, such as sarin and soman. Here, we investigate the binding mechanism f...

journal_title：Toxicology letters

authors： Fu F,Liu H,Gao R,Zhao P,Lu X,Zhang R,Wang L,Wang H,Pei C

更新日期：2020-03-15 00:00:00

abstract：:General anaesthesia is an important measure in the treatment of patients suffering from organophosphorus intoxication. The intravenous anaesthetic etomidate seems to be well suited for this purpose because of its stable haemodynamics. Here we raise the question whether the anaesthetic properties of etomidate are alter...

journal_title：Toxicology letters

authors： Drexler B,Antkowiak B,Thiermann H,Seeger T,Grasshoff C

更新日期：2010-10-20 00:00:00

abstract：:The European Commission has decided on harmonized classifications for a large number of individual chemicals according to its own directive for classification and labeling of dangerous substances. We have compared the harmonized classifications for acute oral toxicity to the acute oral toxicity data available in the R...

journal_title：Toxicology letters

authors： Rudén C,Hansson SO

更新日期：2003-09-30 00:00:00

abstract：:Troglitazone (TGZ) is an orally active hypoglycemic agent which is used for the treatment of non-insulin-dependent diabetes mellitus. It had been associated with severe drug-induced liver failure which resulted in its withdrawal from the market in 2000. While the exact mechanism of its toxicity remains unknown, it has...

journal_title：Toxicology letters

authors： Saha S,New LS,Ho HK,Chui WK,Chan EC

更新日期：2010-02-01 00:00:00

abstract：:Troglitazone (Tro) is a thiazolidinedione antidiabetic drug that was withdrawn from the market due to its association with idiosyncratic severe liver injury. Tro has never induced liver injury in experimental animals in vivo. It was assumed that the species differences between human and experimental animals in the pha...

journal_title：Toxicology letters

authors： Kakuni M,Morita M,Matsuo K,Katoh Y,Nakajima M,Tateno C,Yokoi T

更新日期：2012-10-02 00:00:00

abstract：:cis-Diamminedichloroplatinum(II) (cisplatin) is one of the most effective antitumor agents currently available for cancer chemotherapy. Unfortunately, its clinical use is severely limited by its dose-dependent nephrotoxicity. Recently, it has been reported that this nephrotoxicity is associated with an increase in lip...

journal_title：Toxicology letters

authors： Sadzuka Y,Shoji T,Takino Y

更新日期：1991-07-01 00:00:00

abstract：:The direct or indirect interference with GABA-mediated neurotransmission results in convulsive seizure activity in humans and experimental animals. When this convulsant effect is experimentally analyzed, it turns out to be a product of discrete and restricted cerebral sites of drug action. Depending upon the brain cir...

journal_title：Toxicology letters

authors： Gale K

更新日期：1992-12-01 00:00:00

abstract：:Ambient and biological monitoring was undertaken among tobacco processors who are chronically exposed to tobacco particulates via nasopharyngeal and cutaneous routes. Ambient monitoring revealed that the inspirable dust concentration was 150-fold higher in the tobacco factory than in the control environment, and was a...

journal_title：Toxicology letters

authors： Bhisey RA,Bagwe AN,Mahimkar MB,Buch SC

更新日期：1999-09-05 00:00:00

abstract：:Indomethacin (IND) suppresses the T-dependent antibody response (TDAR) in juvenile males when it is administered to pregnant rats during late gestation. In this study, the effect of IND on cytokine production in juvenile rats was examined to investigate the mechanism behind the suppression of antibody production. IND ...

journal_title：Toxicology letters

authors： Kushima K,Sakuma S,Furusawa S,Fujiwara M

更新日期：2009-02-25 00:00:00

abstract：:The alpha(2)-adrenoceptor antagonist yohimbine is known to interact with the effects of opioid receptor agonists in vivo, and thus could modulate the action of morphine-like analgesics. The focus of the present work was to further study these interactions in a cell culture endowed with opioid and alpha(2)-adrenoceptor...

journal_title：Toxicology letters

authors： Polanco MJ,Alguacil LF,Albella B,Segovia JC,González-Martín C

更新日期：2009-09-10 00:00:00

abstract：:Inorganic arsenic, an early life carcinogen in humans and mice, can initiate lesions promotable by other agents in later life. The biomethylation product of arsenic, dimethylarsinic acid (DMA), is a multi-site tumor promoter. Thus, pregnant CD1 mice were given drinking water (0 ppm or 85 ppm arsenic) from gestation da...

journal_title：Toxicology letters

authors： Tokar EJ,Diwan BA,Waalkes MP

更新日期：2012-03-07 00:00:00

abstract：:Localization of specific mRNA and protein molecules within cells and tissues can provide important information on the effects of a drug within a biological test system and help elucidate mechanisms of drug-induced toxicity and organ dysfunction. The most widely used techniques for measuring the cellular and tissue dis...

journal_title：Toxicology letters

authors： Kind CN

更新日期：2000-03-15 00:00:00

abstract：:Chromium (Cr) is widely used in industry, making its toxicity a matter of concern. Although hexavalent Cr [Cr(VI)] can promote cancer cell proliferation in several cancers, there is little evidence implicating Cr(VI) in cancer cell migration, especially in prostate cancer. We show that the Cr concentration is higher i...

journal_title：Toxicology letters

authors： Zhang C,Cai K,Feng Q,Xu Y,Zhang Z

更新日期：2019-01-01 00:00:00

abstract：:Oral administration of stannous chloride (SnCl2) (1.0 mg Sn2$/kg body weight) to rats, twice daily for 28 days, caused a significant increase in the tin (Sn) content and a corresponding decrease of the calcium (Ca) content in the femoral epiphysis, but was without effect on serum Ca, intestinal Ca absorption, and urin...

journal_title：Toxicology letters

authors： Yamaguchi M,Sugii K,Okada S

更新日期：1982-01-01 00:00:00

abstract：:The liver carcinogen N-nitrosodimethylamine (NDMA) has to be metabolically activated by specific cytochromes before it can react with cellular macromolecules (e.g. proteins or DNA). Although hepatocytes are believed to be responsible for this activation, the liver tumours originate mainly from non-parenchymal cells (N...

journal_title：Toxicology letters

authors： Frei E,Kuchenmeister F,Gliniorz R,Breuer A,Schmezer P

更新日期：2001-09-15 00:00:00

abstract：:The aim of this study was to establish an air-liquid interface (ALI) culture of precision-cut lung slices (PCLS) for direct exposure of lung cells to gaseous contaminants. Nitrogen dioxide (NO(2)) and ozone (O(3)) were selected as model gas compounds. Acute pro-inflammatory and toxic effects of NO(2) and O(3) on live ...

journal_title：Toxicology letters

authors： Switalla S,Knebel J,Ritter D,Krug N,Braun A,Sewald K

更新日期：2010-07-01 00:00:00

abstract：:Male Swiss OF1 mice received a single oral dose of either 80 mg/kg hexachloro-1,3-butadiene (HCBD) or 80 mg/kg methyl mercury (MeHg). Examination of cryostat kidney sections stained for alkaline phosphatase (APP) revealed damage to about 50% of the proximal tubules after 8 h. Pretreatment with the gamma-glutamyltransp...

journal_title：Toxicology letters

authors： de Ceaurriz J,Ban M

更新日期：1990-02-01 00:00:00

abstract：:The distribution of mercury to the brain following an injection of methylmercury (MeHg) or ethylmercury (EtHg) was examined in immature mice. Postnatal day (PND) 16 CD1 mice received MeHg chloride either by IM injection or by gavage. At 24 h and 7 days post-injection, total mercury concentrations were determined in bl...

journal_title：Toxicology letters

authors： Harry GJ,Harris MW,Burka LT

更新日期：2004-12-30 00:00:00

abstract：:Phenathrene is a major coal tar component found in hazardous waste disposal sites. The purpose of this study was to evaluate the extent to which phenanthrene adsorption to either of 2 different soils affects the manner in which phenanthrene is subsequently handled in orally and dermally exposed adult female rats. Abso...

journal_title：Toxicology letters

authors： Kadry AM,Skowronski GA,Turkall RM,Abdel-Rahman MS

更新日期：1995-07-01 00:00:00

abstract：:Dioxins are persistent environmental contaminants that cause multiple disorders in laboratory animals, including teratogenesis. In mice, the most important teratogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are hydronephrosis and cleft palate. Aryl hydrocarbon receptor (AHR) mediates most of the TCDD-in...

journal_title：Toxicology letters

authors： Miettinen HM,Huuskonen H,Partanen AM,Miettinen P,Tuomisto JT,Pohjanvirta R,Tuomisto J

更新日期：2004-05-02 00:00:00