Abstract：
:The target cell(s) of theobromine toxicity on rat testes and reproductive toxicity induced by pure theobromine and cocoa extract are evaluated in the present studies. Theobromine (500 mg/kg x 7 days) inhibited body weight gain in treated rats. Decreased cauda epididymal sperm reserve (38%), seminiferous tubule fluid (STF) volume (33%), lactate concentration in STF (22%), inhibition of binding activity of androgen binding protein (ABP, 21%) and reduced ABP content in STF were also observed in theobromine-treated animals. Cocoa extract containing an equivalent amount of theobromine did not produce significant toxicity in treated rats. Theobromine concentrations in serum and testes from pure theobromine-treated rats were 1.8- and 1.6-fold higher, respectively, than that in rats treated with cocoa extract. The results support Sertoli cells as the primary target cells of theobromine toxicity. The lower theobromine concentrations in serum and testes of cocoa extract-treated rats could account for the lower toxicity in these animals.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Wang Y,Waller DPdoi
10.1016/0378-4274(94)90159-7subject
Has Abstractpub_date
1994-02-01 00:00:00pages
155-64issue
2eissn
0378-4274issn
1879-3169pii
0378-4274(94)90159-7journal_volume
70pub_type
杂志文章abstract：:Environmental exposure to the highly persistent chlorinated pesticides including dieldrin and lindane is postulated to be a risk factor to the development of Parkinson's disease, a devastating movement disorder. We have previously reported that the combined treatment with dieldrin and lindane induces a cooperative tox...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2018.09.006
更新日期：2018-12-15 00:00:00
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journal_title：Toxicology letters
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1992-01-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2007-04-05 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1989-09-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1984-10-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2020-02-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.09.008
更新日期：2013-11-25 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.02.001
更新日期：2013-04-26 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2004.01.028
更新日期：2004-06-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(94)03174-6
更新日期：1995-01-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2015.10.027
更新日期：2016-01-05 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(82)90244-2
更新日期：1982-08-01 00:00:00
abstract：:This study describes two phases of a multi-phase project aiming to validate a mouse model for cow's milk allergy to assess the potential allergenicity of hydrolysed cow's milk based infant formulas (claim support EC-directive 2006/141/E). The transferability and the discriminatory power of this model was evaluated in ...
journal_title：Toxicology letters
pub_type： 杂志文章,多中心研究
doi：10.1016/j.toxlet.2013.04.008
更新日期：2013-06-20 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2010.03.014
更新日期：2010-06-16 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2003-01-31 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2007-12-10 00:00:00
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journal_title：Toxicology letters
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更新日期：1980-03-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1995-11-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2019-12-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：2018-01-05 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(81)90035-7
更新日期：1981-10-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2009.04.020
更新日期：2009-08-25 00:00:00
abstract：:Chronic feeding of male Wistar rats with food containing hexachlorobenzene (HCB) at 17.5 mmol/kg induced elevation of serum amino-transferases and bilirubin content, increase of microsomal cytochrome P-450 concentration, and decrease of 5'-nucleotidase, K+,Na+- and Mg2+-adenosine triphosphatase activities in liver pla...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(86)90118-9
更新日期：1986-09-01 00:00:00
abstract：:Pyrethroid pesticides are used preferably over organochlorines and organophosphates due to their high effectiveness, low toxicity to non-target organisms and easy biodegradibility. However, it is possible that during the pyrethroid metabolism, there is generation of reactive oxygen species (ROS) and pyrethroids may pr...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(98)00399-3
更新日期：1999-04-12 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(88)90116-6
更新日期：1988-09-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2017.05.020
更新日期：2017-07-05 00:00:00
