Chromium(VI) promotes cell migration through targeting epithelial-mesenchymal transition in prostate cancer.

abstract：:Stoichiometric conversion of methyl acetate to methanol in vitro was detected when methyl acetate was incubated with blood for 2 to 8 h. The velocity of the reaction was so fast that almost all of methyl acetate disappeared in 8 h. The methanol formation was further confirmed by means of gas-chromatography-mass spectr...

journal_title：Toxicology letters

authors： Mizunuma K,Kawai T,Yasugi T,Horiguchi S,Iwami O,Ikeda M

更新日期：1992-09-01 00:00:00

abstract：:Cadmium-binding proteins (CdBPs) in the cytosol fractions from several organs of man orally exposed to cadmium (Cd) were examined by gel chromatography. In kidney and liver most of the cadmium (76-87%) in the cytosols was bound to metallothionein, and hepatic metallothionein contained zinc also at a similar level. The...

journal_title：Toxicology letters

authors： Sato M,Takizawa Y

更新日期：1982-05-01 00:00:00

abstract：:Bilitranslocase (BTL) is a plasma membrane carrier that transports organic anions of physiological and pharmacological interest. It is expressed in basolateral plasma membrane of kidney and liver. BTL has been recently described as a marker of transition from normal tissue to its neoplastic transformation in human kid...

journal_title：Toxicology letters

authors： Trebucobich MS,Hazelhoff MH,Chevalier AA,Passamonti S,Brandoni A,Torres AM

更新日期：2014-03-03 00:00:00

abstract：:Nickel (Ni) can disorder testosterone synthesis in rat Leydig cells, whereas the mechanisms remain unclear. The aim of this study was to investigate the role of reactive oxygen species (ROS) and mitogen-activated protein kinases (MAPKs) in Ni-induced disturbance of testosterone synthesis in rat Leydig cells. The testo...

journal_title：Toxicology letters

authors： Han A,Zou L,Gan X,Li Y,Liu F,Chang X,Zhang X,Tian M,Li S,Su L,Sun Y

更新日期：2018-06-15 00:00:00

abstract：:We investigated the characteristics of hepatic cytochrome P450s and flavin-containing monooxygenase 1 (FMO1) in male Nts:Mini rats, a Wistar/Jcl-derived transgenic rat strain showing less plasma GH concentration than the parental strain. The total hepatic P450 contents of Mini rats were significantly reduced. A suppre...

journal_title：Toxicology letters

authors： Tani Y,Yamamoto H,Kawaji A,Mizuno H,Fukushige J,Hosokawa T,Doi K

更新日期：1999-06-01 00:00:00

abstract：:Accumulation of macrophages and neutrophil granulocytes in the lung are key events in the inflammatory response to inhaled particles. The present study aims at the time course of chemotaxis in vitro in response to the challenge of various biopersistent particles and its functional relation to the transcription of infl...

journal_title：Toxicology letters

authors： Schremmer I,Brik A,Weber DG,Rosenkranz N,Rostek A,Loza K,Brüning T,Johnen G,Epple M,Bünger J,Westphal GA

更新日期：2016-11-30 00:00:00

abstract：:Paraquat poisoning results in damages of multiple organs including liver, kidney and lung, and antioxidants have been proven to have protective effects. As a novel free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), was introduced to clinical use recently, its protective effect was studied on acute ...

journal_title：Toxicology letters

authors： Saibara T,Toda K,Wakatsuki A,Ogawa Y,Ono M,Onishi S

更新日期：2003-06-05 00:00:00

abstract：:The relative deposition of inhaled heterodisperse particles of the size of environmental tobacco smoke (ETS, mass median aerodynamic diameter 0.2 micron, geometric standard deviation 1.5) is about the same in the tracheobronchial tree and is lower in the pulmonary region of the rat than in the same regions of humans. ...

journal_title：Toxicology letters

authors： Oberdörster G,Pott F

更新日期：1987-01-01 00:00:00

abstract：:There have been many concerns about the possible adverse effects of thyroid hormone-disrupting chemicals in the environment. Because thyroid hormones are essential for regulating the growth and differentiation of many tissues, disruption of thyroid hormones during the neonatal period of an organism might lead to perma...

journal_title：Toxicology letters

authors： Fujimoto N,Kitamura S,Uramaru N,Miyagawa S,Iguchi T

更新日期：2018-04-01 00:00:00

abstract：:3-methyladenine DNA glycosylase (AlkD) belongs to a new family of DNA glycosylases; it initiates repair of cytotoxic and promutagenic alkylated bases (its main substrates being 3-methyladenine and 7-methylguanine). The modification of the comet assay (single cell gel electrophoresis) using AlkD enzyme thus allows asse...

journal_title：Toxicology letters

authors： Hašplová K,Hudecová A,Magdolénová Z,Bjøras M,Gálová E,Miadoková E,Dušinská M

更新日期：2012-01-05 00:00:00

abstract：:Dithiocarbamate propineb and maneb are organometal fungicides, which are widely used for the control of diseases in plants. Female Wistar rats were exposed orally to 200 and 400 ppm propineb and 250 ppm maneb, from the sixth day of gestation up to birth. We found that the body weights of both one-day old litters and t...

journal_title：Toxicology letters

authors： Guven K,Deveci E,Akba O,Onen A,de Pomerai D

更新日期：1998-10-15 00:00:00

abstract：:The activities of vanadium oxide (V2O3), vanadyl sulfate (VOSO4) and ammonium metavanadate (NH4VO3) in inducing sister chromatid exchange (SCE) and chromosomal aberrations (CAb) were assayed in Chinese hamster ovary cells. The toxic concentrations (TC50) for these compounds were found to be 25, 23 and 16 micrograms el...

journal_title：Toxicology letters

authors： Owusu-Yaw J,Cohen MD,Fernando SY,Wei CI

更新日期：1990-02-01 00:00:00

abstract：:The involvement of neurotrophins after radiation injury during brain development were studied in pregnant mice (C 57/B1) exposed on gestation day 15 to X-ray doses of 0.02-2 Gy. Nerve growth factor protein (NGF) and different cholinergic markers were investigated on postnatal day 1 (P1) and day 21 (P21); in situ hybri...

journal_title：Toxicology letters

authors： Dimberg Y,Vazquez M,Söderström S,Ebendal T

更新日期：1997-01-15 00:00:00

abstract：:Oxime-based acetylcholinesterase reactivators (briefly oximes) regenerate organophosphate-inactivated acetylcholinesterase and restore its function. Poor blood-brain-barrier passage and fast elimination from blood limit their actual use in treatment of patients exposed to organophosphates. Previous in vitro results im...

journal_title：Toxicology letters

authors： Zdarova Karasova J,Hepnarova V,Andrys R,Lisa M,Jost P,Muckova L,Pejchal J,Herman D,Jun D,Kassa J,Kuca K

更新日期：2020-03-01 00:00:00

abstract：:Hexavalent chromium (Cr (VI)) is an environmental human carcinogen which primarily targets lungs. Among a variety of toxic mechanisms, disruption of biological pathways via translational and post-translational modifications represents a key mechanism through which Cr (VI) induces cytotoxicity and carcinogenesis. To id...

journal_title：Toxicology letters

authors： Bruno M,Ross J,Ge Y

更新日期：2016-12-15 00:00:00

abstract：:Inorganic arsenic has strong human carcinogenic potential, but the availability of an animal model to study toxicity is extremely limited. Here, we used the transgenic zebrafish line Tg(k18(2.9):RFP) as an animal model to study arsenite toxicity. This line was chosen because the red fluorescent protein (RFP) is expres...

journal_title：Toxicology letters

authors： Wang YH,Chen YH,Wu TN,Lin YJ,Tsai HJ

更新日期：2006-06-01 00:00:00

abstract：:Chlordimeform (Cdf) is readily absorbed through the skin of pesticide applicators. It also enters the body when breathed into the lungs. Cdf can be found in the urine of workers who handle or are involved in applying pesticide products which contain the chemical, even when they are wearing special protective clothing ...

journal_title：Toxicology letters

authors： Maddy KT,Knaak JB,Gibbons DB

更新日期：1986-10-01 00:00:00

abstract：:Dichloromethane (DCM) elimination and carboxyhemoglobin (COHb) generation were examined in adult female SD rats pretreated with a glutathione (GSH) depletor(s). Rats were treated with either buthionine sulfoximine (BSO; 2 mmol/kg, i.p.), diethylmaleate (DEM; 3 mmol/kg, i.p.), phorone (PHO; 1 mmol/kg, i.p.) or BSO plus...

journal_title：Toxicology letters

authors： Oh SJ,Kim SK,Kim YC

更新日期：2002-03-24 00:00:00

abstract：:This study aimed to evaluate bio-safety of magnetic chitosan nanogels as dual triggered drug carrier for doxorubicin through analysis of mitochondrial function. In the present study, chitosan/TPP nanogels containing magnetite nanoparticles (NPs) were prepared according to the ionotropic gelation method as novel pH-sen...

journal_title：Toxicology letters

authors： Sadighian S,Rostamizadeh K,Hosseini MJ,Hamidi M,Hosseini-Monfared H

更新日期：2017-08-15 00:00:00

abstract：:The effect of feeding a diet containing 5% tansy ragwort (TR) (Senecio jacobaea), a poisonous plant containing pyrrolizidine alkaloids (PA), on the blood and liver levels of copper, zinc, iron and vitamin A in broiler chicks was examined. Serum and liver copper and liver iron concentrations were increased in chicks fe...

journal_title：Toxicology letters

authors： Huan J,Cheeke PR,Lowry RR,Nakaue HS,Snyder SP,Whanger PD

更新日期：1992-09-01 00:00:00

abstract：:In vitro effects of mercury-selenium compounds, as compared with mercurials, against glucose-6-phosphate dehydrogenase (G6PD), catalase and trypsin were studied. Inhibitory potencies of two mercury-selenium (Hg-Se) compounds, bis(methylmercuric) selenide (BMS), and a reaction product of HgCl2, Na2SeO3 and glutathione ...

journal_title：Toxicology letters

authors： Mochizuki Y,Kobayashi T,Doi R

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:Oxidative stress is one of the main pathogenic mechanisms in vancomycin-induced nephrotoxicity (VIN). Some studies suggest proximal renal tubular cell necrosis by vancomycin accumulation as a mechanism of nephrotoxicity, and other studies demonstrate that cilastatin has protective effects against drug-induce...

journal_title：Toxicology letters

authors： Im DS,Shin HJ,Yang KJ,Jung SY,Song HY,Hwang HS,Gil HW

更新日期：2017-08-05 00:00:00

abstract：OBJECTIVES:Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Maximal oxime effects are expected when effective doses are administered as soon as possible and as long as reactivation can be anticipated. An obidoxime plasma level i...

journal_title：Toxicology letters

authors： Thiermann H,Eyer F,Felgenhauer N,Pfab R,Zilker T,Eyer P,Worek F

更新日期：2010-09-01 00:00:00

abstract：:There are reports of fluorochloridone (FLC)-induced male reproductive toxicity, but the underlying toxicological mechanisms remain unknown. In this study, we looked at how FLC exposure affected the integrity of the blood-testis barrier (BTB) and the Sertoli cell barrier and studied the molecular mechanisms. Male rats ...

journal_title：Toxicology letters

authors： Liu L,Zhang Y,Chang X,Li R,Wu C,Tang L,Zhou Z

更新日期：2018-10-01 00:00:00

abstract：:To test the toxicity of some substances, known to affect the nervous system i.e. organic solvents, heavy metals and DDT, their ability to cause cell detachment of cultured mouse neuroblastoma cells was investigated. A TD25 value was obtained by graphic estimation of the concentration needed to cause 25% of the total c...

journal_title：Toxicology letters

authors： Peterson A,Lewné M,Walum E

更新日期：1981-10-01 00:00:00

abstract：:The development of three generic multi-compartment physiologically based kinetic (PBK) models is described for farm animal species, i.e. cattle, sheep, and swine. The PBK models allow one to quantitatively link external dose and internal dose for risk assessment of chemicals relevant to food and feed safety. Model per...

journal_title：Toxicology letters

authors： Lautz LS,Hoeks S,Oldenkamp R,Hendriks AJ,Dorne JLCM,Ragas AMJ

更新日期：2020-01-01 00:00:00

abstract：:We have found that a single dose of amitraz, a formamidine pesticide, produces death in mice 2-5 days after dosing. To further examine this phenomenon, adult albino mice of both sexes were treated with either yohimbine (10 mg/kg, i.p.) or deionized water (6 ml/kg, i.p.), immediately before an injection of amitraz (600...

journal_title：Toxicology letters

authors： Moser VC,MacPhail RC

更新日期：1985-11-01 00:00:00

abstract：:Although the interest is growing towards glyoxalases and methylglyoxal, their role in metabolism is still an enigma. In this paper, the effects of methylglyoxal in both in vivo and in vitro mammalian systems are reviewed and correlated with its interaction with macromolecules (nucleic acids, proteins). The theories on...

journal_title：Toxicology letters

authors： Kalapos MP

更新日期：1994-07-01 00:00:00

abstract：:Occupational and environmental exposure to pesticides has been associated with thyroid dysfunction, particularly changes in circulating thyroid hormone levels (T3, T4) and thyroid stimulating hormone (TSH). This study assessed the association between environmental exposure to pesticides and the risk of developing thyr...

journal_title：Toxicology letters

authors： Requena M,López-Villén A,Hernández AF,Parrón T,Navarro Á,Alarcón R

更新日期：2019-10-15 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an environmental toxin that induces apoptosis of neurons and a pro-inflammatory response in microglial cells. First, we found that TCDD induced proliferation of HAPI microglial cells in a dose- and time-dependent manner. Flow cytometry analysis showed that this proliferati...

journal_title：Toxicology letters

authors： Xu G,Li Y,Yoshimoto K,Wu Q,Chen G,Iwata T,Mizusawa N,Wan C,Nie X

更新日期：2014-01-30 00:00:00