Comparative proteomic analysis of fluoride treated rat bone provides new insights into the molecular mechanisms of fluoride toxicity.

abstract：:Neuron specific enolase (ENO2, γ-enolase) is a biomarker used to help identify neuroendocrine differentiation in tumors. This laboratory has shown that ENO2 might be a biomarker for exposure to cadmium and arsenite. In this study these observations are extended to the urothelial cell, where environmental exposures are...

journal_title：Toxicology letters

authors： Soh M,Dunlevy JR,Garrett SH,Allen C,Sens DA,Zhou XD,Sens MA,Somji S

更新日期：2012-07-07 00:00:00

abstract：:Palytoxins (PLTXs) are known seafood contaminants and their entrance into the food chain raises concern about possible effects on human health. The increasing number of analogs being identified in edible marine organisms complicates the estimation of the real hazard associated with the presence of PLTX-like compounds....

journal_title：Toxicology letters

authors： Del Favero G,Sosa S,Poli M,Tubaro A,Sbaizero O,Lorenzon P

更新日期：2014-03-03 00:00:00

abstract：:The effect of different doses of methylglyoxal (50-400 mg/kg body wt.) were examined using enzymes involved in the antioxidant function, glutathione (GSH) content and lipid peroxidation in the liver and spleen of Swiss albino mice (7-8 week old) after 6, 12 and 24 h. Significant changes were observed predominantly in ...

journal_title：Toxicology letters

authors： Choudhary D,Chandra D,Kale RK

更新日期：1997-12-01 00:00:00

abstract：RATIONALE:The popularity of new and emerging tobacco products such as E-cigarettes (E-cigs) is rapidly expanding worldwide. However, uncertainties surrounding the potential health consequences due to the use of such products exist and warrant further study. METHODS:Cultured A549 and Calu-3 airway epithelia were expose...

journal_title：Toxicology letters

authors： Zhang R,Jones MM,Dornsife RE,Wu T,Sivaraman V,Tarran R,Onyenwoke RU

更新日期：2021-02-01 00:00:00

abstract：:A single, 50 mg/kg i.p. dose of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) to mice significantly inhibited glutathione reductase activity in liver within 10 min, and in lung and heart within 30 min. Maximal inhibition was reached at 4 h in all tissues and glutathione reductase activity remained significantly depress...

journal_title：Toxicology letters

authors： Kehrer JP

更新日期：1983-06-01 00:00:00

abstract：:Many industrially and environmentally important industrial carcinogens display effects that lead them to be viewed and regulated as 'genotoxic compounds'. Some of these chemicals cause experimental tumours only at high or toxic doses. The current view is that non-threshold principles should be applied for risk assessm...

journal_title：Toxicology letters

authors： Bolt HM

更新日期：2003-04-11 00:00:00

abstract：:Deoxynivalenol (DON) is a type B trichothecene mycotoxin that exerts multiple toxic effects on plants, animals and humans. Several reports have shown that DON leads to G2/M cell cycle arrest. However, its molecular mechanism is still unclear. In this study, we showed that DON induced strong G2/M cell cycle arrest in H...

journal_title：Toxicology letters

authors： Yuan L,Mu P,Huang B,Li H,Mu H,Deng Y

更新日期：2018-12-15 00:00:00

abstract：:Male C57B1/6N mice, 8-10 weeks old were given a single oral dose of 0, 1.0 or 3.0 mg/kg body weight of trimethyltin hydroxide (TMT). Levels of ornithine decarboxylase (ODC) activity were measured in several brain areas, 1, 2 and 7 days later. The lower dose of TMT produced a decrease of ODC in the caudate nucleus and ...

journal_title：Toxicology letters

authors： Ali SF,Newport GD,Slikker W Jr,Bondy SC

更新日期：1987-03-01 00:00:00

abstract：:Intraperitoneal (i.p.) administration of a cadmium (Cd) salt at concentrations of 1.0, 2.5 and 4.0 mg CdCl2/kg body wt. caused severe liver injury in rats 24 h after administration. The toxic effects were most evident in the intermediate dose of 2.5 mg. Thymidine kinase (TK), the key enzyme of the salvage pathway of D...

journal_title：Toxicology letters

authors： Theocharis SE,Margeli AP,Ghiconti IK,Varonos D

更新日期：1992-11-01 00:00:00

abstract：:The aim of this study was to establish a methodology to analyze estrogen quinone-derived adducts, including 17β-estradiol-2,3-quinone (E2-2,3-Q) and 17β-estradiol-3,4-quinone (E2-3,4-Q), in human hemoglobin (Hb). The methodology was then used to measure the levels of these adducts in Hb derived from female breast canc...

journal_title：Toxicology letters

authors： Lin C,Hsieh WC,Chen DR,Kuo SJ,Yu WF,Hu SW,Sue HJ,Ko MH,Juan CH,Chung KS,Lin PH

更新日期：2014-03-21 00:00:00

abstract：:Ebselen is a seleno-organic compound that causes cell death in several cancer cell types. The mechanisms underlying its deleterious effects have not been fully elucidated. In this study, the effects of ebselen (1 μM-40 μM) on AR42J tumor cells have been examined. Cell viability was studied using AlamarBlue(®) test. Ce...

journal_title：Toxicology letters

authors： Santofimia-Castaño P,Garcia-Sanchez L,Ruy DC,Fernandez-Bermejo M,Salido GM,Gonzalez A

更新日期：2014-09-17 00:00:00

abstract：:Diclofenac is a widely prescribed NSAID that causes severe idiosyncratic drug induced liver injury (IDILI) in a small part of the patient population. Formation of protein-reactive metabolites is considered to play a role in the development of diclofenac-induced IDILI. Therefore, a high hepatic activity of enzymes invo...

journal_title：Toxicology letters

authors： den Braver MW,Zhang Y,Venkataraman H,Vermeulen NP,Commandeur JN

更新日期：2016-07-25 00:00:00

abstract：:Crotonaldehyde is an environment pollutant and lipid peroxidation product. Crotonaldehyde produces adverse effects to humans and serves as a risk factor for human pulmonary diseases. Like acrolein and 4-hydroxynonenal, crotonaldehyde seems likely to alter many cell signaling cascades, including inflammatory responses....

journal_title：Toxicology letters

authors： Liu XY,Yang ZH,Pan XJ,Zhu MX,Xie JP

更新日期：2010-08-16 00:00:00

abstract：:(1) The hypothesis that inhalational anesthetics affect G-protein linked alpha2 adrenergic signaling pathway was investigated using human platelets as a model system. (2) Alpha2 receptor stimulation by UK-14304, a potent and selective agonist, inhibits cAMP production induced by prostaglandin I2 (PGI2). (3) Brief stim...

journal_title：Toxicology letters

authors： Pentyala S,Moller D,Chowdhury A,Sung KY,Rebecchi M

更新日期：1998-11-23 00:00:00

abstract：:E-64d (a calpain and autophagy inhibitor) has previously been shown safe for the treatment of Alzheimer's disease in humans. In the present study, the potential protective mechanism of E-64d on hippocampal aberrant mossy fiber sprouting was examined in a developmental rat model of penicillin-induced recurrent epilepti...

journal_title：Toxicology letters

authors： Ni H,Ren SY,Zhang LL,Sun Q,Tian T,Feng X

更新日期：2013-02-27 00:00:00

abstract：:Chemical-peptide conjugation is the molecular initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatography/ultraviolet (HPLC/UV) detection method to quantify chemical-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two sy...

journal_title：Toxicology letters

authors： Wei Z,Fang Y,Gosztyla ML,Li AJ,Huang W,LeClair CA,Simeonov A,Tao D,Xia M

更新日期：2021-03-01 00:00:00

abstract：:The effects of lead exposure have been studied upon the behavioural and diuretic responses to the kappa-opioid receptor agonist U-50488H in neonatal rats. Lead was administered in the maternal drinking water (100, 300 and 1000 ppm) from conception to postnatal day 14. The hyperactivity, wall climbing behaviours and di...

journal_title：Toxicology letters

authors： Jackson HC,Kitchen I

更新日期：1990-01-01 00:00:00

abstract：:Pregnant mice of C57BL/6 and DBA/2 inbred strains were exposed to cigarette smoke during days 1-18 of pregnancy. Both mothers and offspring were killed at the age of 21-22 weeks, and ovaries were studied with respect to the number of primordial follicles and small primary follicles. In additional studies, 7,12-dimethy...

journal_title：Toxicology letters

authors： Vähäkangas K,Rajaniemi H,Pelkonen O

更新日期：1985-04-01 00:00:00

abstract：:Sister-chromatid exchanges (SCEs) were analyzed from peripheral lymphocyte cultures of 8 men and 16 women who had been exposed to environmental cadmium (Cd), and 6 controls. Average Cd concentrations in blood of the Cd-polluted group were 8.9 micrograms/l for men and 10.0 micrograms/l for women. These were no signific...

journal_title：Toxicology letters

authors： Nogawa K,Tsuritani I,Yamada Y,Kido T,Honda R,Ishizaki M,Kurihara T

更新日期：1986-09-01 00:00:00

abstract：:Deoxynivalenol (DON), 3-acetyldeoxynivalenol (acetylDON) and zearalenone (Ze) were examined for their in vitro effect on mitogen-induced lymphocyte blastogenesis using rat or human peripheral blood lymphocytes (PBL). A dose-dependent reduction of lymphocyte proliferation was demonstrated for each mycotoxin. However, t...

journal_title：Toxicology letters

authors： Atkinson HA,Miller K

更新日期：1984-11-01 00:00:00

abstract：:Di-(2-propylheptyl) phthalate (DPHP) is used as a plasticizer for polyvinyl chloride products. A tolerable daily intake of DPHP of 0.2 mg/kg body weight has been derived from rat data. Because toxicokinetic data of DPHP in humans were not available, it was the aim of the present work to monitor DPHP and selected metab...

journal_title：Toxicology letters

authors： Klein D,Kessler W,Pütz C,Semder B,Kirchinger W,Langsch A,Gries W,Otter R,Gallien AKE,Wurzenberger X,Filser JG

更新日期：2018-09-15 00:00:00

abstract：:Between 1997 and 2011, more than 200 new substances were notified through the early-warning system, with the record number of 49 novel molecules reported in 2011. The pattern of acute toxicity associated with the consumption of these new substances is generally similar to that seen with traditional drugs of abuse. Rec...

journal_title：Toxicology letters

authors： Coppola M,Mondola R

更新日期：2012-07-07 00:00:00

abstract：:The dose-dependent effects of sodium saccharin on the fertility and the induction of chromosomal translocations in treated mice and their F1 males were examined. C3H X 101 mice were treated with saccharin for 2 successive weeks at doses of 200 and 500 mg/kg of body wt. Data from the fertility study showed that sacchar...

journal_title：Toxicology letters

authors： Pecevski J,Vuksanović L,Savković N,Alavantić D,Radivojević D

更新日期：1983-12-01 00:00:00

abstract：:The effects of sodium tellurite 0.1 and 0.4 mg/kg were assessed in the Morris water maze. Two days after treatment rats were tested for acquisition (posttreatment days 3-6) and on seventh day on a spatial retention task. Tellurium treatment was found to cause significant impairment in retention of the spatial learning...

journal_title：Toxicology letters

authors： Widy-Tyszkiewicz E,Piechal A,Gajkowska B,Smiałek M

更新日期：2002-05-28 00:00:00

abstract：:Reactive oxygen species (ROS) have been implicated in various pulmonary diseases by causing direct injury to lung epithelial cells. Signalling activity of cells through transcription factors such as nuclear factor kappa B (NF-kappaB) and AP-1 have been shown to be regulated by ROS, and the release of pro-inflammatory ...

journal_title：Toxicology letters

authors： Brown DM,Hutchison L,Donaldson K,MacKenzie SJ,Dick CA,Stone V

更新日期：2007-01-10 00:00:00

abstract：:Melamine (MA) exposure causes male reproductive toxicity, however, the mechanism remains unclear. In this study, we investigated the roles of the blood-testis barrier (BTB) in MA-induced reproductive toxicity in piglets. Male weaned piglets were exposed to MA concentrations of 0, 100, 300, and 1000 mg/kg in the diet f...

journal_title：Toxicology letters

authors： Chang L,Lu Z,Li D,Zhang L,Wang Z,Du Q,Huang Y,Zhao X,Tong D

更新日期：2018-10-15 00:00:00

abstract：:The common food preparation processes, frying, broiling and baking, can give rise to air pollutants that are known to be mutagenic and carcinogenic in animal tests. A large number of persons can be exposed to such fumes as cooking is performed in most households and in many commercial enterprises. Additional studies o...

journal_title：Toxicology letters

authors： Löfroth G

更新日期：1994-06-01 00:00:00

abstract：:Poly(ADP-ribose) polymerases (PARPs) are a group of protein-modifying and nucleotide-polymerizing enzymes able to catalyze the transfer of multiple ADP-ribose units from NAD to substrate proteins. In the human genome, 16 different genes encoding for members of this emerging family of enzymes have been identified. Know...

journal_title：Toxicology letters

authors： Meli E,Pangallo M,Baronti R,Chiarugi A,Cozzi A,Pellegrini-Giampietro DE,Moroni F

更新日期：2003-04-04 00:00:00

abstract：:Styrene-acrylonitrile trimer (SAN Trimer), a mixture of six isomers (four isomers of 4-cyano-1,2,3,4-tetrahydro-alpha-methyl-1-naphthaleneacetonitrile [THAN] and two isomers of 4-cyano-1,2,3,4-tetrahydro-1-naphthaleneproprionitrile [THNP]), is a by-product of a specific production process of styrene-acrylonitrile poly...

journal_title：Toxicology letters

authors： Gargas ML,Collins B,Fennell TR,Gaudette NF Jr,Sweeney LM

更新日期：2008-04-21 00:00:00

abstract：:Combined effects of mycotoxin mixtures are of major concern due to the widespread occurrence of human exposure to mixtures. Owing to the lack of sufficient mixture data regarding the human immune function, the aim of this study was to specify, evaluate and predict the combined effects of mycotoxin mixtures upon the fu...

journal_title：Toxicology letters

authors： Tammer B,Lehmann I,Nieber K,Altenburger R

更新日期：2007-04-25 00:00:00