Abstract：
:The objective of the present study was to identify the polychlorinated biphenyl congeners of Aroclor 1254 that are responsible for the induction of the cytosolic bioactivation of aromatic amines. Various chlorobiphenyls, ranging from di- to hexa-substituted, were administered to rats and the ability of the hepatic cytosol to bioactivate 2-aminoanthracene and 2-aminofluorene was investigated. These studies revealed that the induction of the cytosolic activation of aromatic amines increased with the increasing extent of chlorination; moreover, planar congeners were more effective inducers of this activity compared to their non-planar isomers. This observation prompted us to investigate whether the cytosolic activation of aromatic amines is associated with the Ah receptor. Treatment of mice with Aroclor 1254 stimulated the cytosolic activation of aromatic amines in C57BL6 mice, an Ah-responsive strain, whereas it had no effect in DBA2 mice, a non-responsive strain. These findings indicate that the bioactivation of aromatic amines by the liver cytosol is linked to the Ah receptor.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Marczylo T,Ioannides Cdoi
10.1016/s0378-4274(97)00042-8subject
Has Abstractpub_date
1997-07-21 00:00:00pages
81-91issue
2eissn
0378-4274issn
1879-3169pii
S0378-4274(97)00042-8journal_volume
92pub_type
杂志文章abstract：:Manganese (Mn) is an indispensable cofactor for many enzymes and a basic factor for many reproductive and metabolic pathways. However, exposure to high concentrations of Mn can result in deleterious effects on the central nervous system and peripheral nerves, including nerves associated with the auditory system. Based...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2017.07.903
更新日期：2017-09-05 00:00:00
abstract：:Policosanol is a natural mixture of higher aliphatic primary alcohols. Oral toxicity of policosanol was evaluated in a 12-month study in which doses from 0.5 to 500 mg/kg were given orally to Sprague Dawley (SD) rats (20/sex/group) daily. There was no treatment-related toxicity. Thus, effects on body weight gain, food...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(94)90147-3
更新日期：1994-01-01 00:00:00
abstract：:This study was designed to compare the pulmonary cellular proliferative effects of inhaled, size-separated preparations of chrysotile asbestos fibres with similar aerosol fibre concentrations of para-aramid fibrils. Following fibre preparation, rats were exposed for 2 weeks to aerosols of p-aramid fibrils or chrysotil...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(96)03751-4
更新日期：1996-11-01 00:00:00
abstract：:There are reports of fluorochloridone (FLC)-induced male reproductive toxicity, but the underlying toxicological mechanisms remain unknown. In this study, we looked at how FLC exposure affected the integrity of the blood-testis barrier (BTB) and the Sertoli cell barrier and studied the molecular mechanisms. Male rats ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2018.07.001
更新日期：2018-10-01 00:00:00
abstract：:This study aimed to evaluate bio-safety of magnetic chitosan nanogels as dual triggered drug carrier for doxorubicin through analysis of mitochondrial function. In the present study, chitosan/TPP nanogels containing magnetite nanoparticles (NPs) were prepared according to the ionotropic gelation method as novel pH-sen...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2017.06.004
更新日期：2017-08-15 00:00:00
abstract：:The disposition of methanol and its putative toxic metabolite formate has been studied in humans, non-human primates, and rodents after exposure to high, neurotoxic doses. The rate at which rodents detoxify formate is more rapid than that of primates. Formate, an endogenous biological substrate, is detoxified by metab...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(95)03515-x
更新日期：1995-12-01 00:00:00
abstract：:Reactivity of phenoxyl radicals towards biomolecules (proteins, nucleic acids and lipids) is essential for antioxidant (protective) versus prooxidant (cytotoxic) effects of phenolic compounds (antioxidants, phytochemicals, environmental pollutants and toxic chemicals). The present study demonstrates for the first time...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(96)03767-8
更新日期：1996-10-01 00:00:00
abstract：:The co-ordinated glucuronidation and export of compounds from cells is an important determinant in the detoxification of many compounds in vivo. Many UDP-glucuronosyltransferases (UGTs) and several multidrug resistance proteins (MRPs) have been cloned and individually expressed to assess specificity of glucuronidation...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(01)00305-8
更新日期：2001-03-31 00:00:00
abstract：:Untargeted metabolomic approaches offer new opportunities for a deeper understanding of the molecular events related to toxic exposure. This study proposes a metabolomic investigation of biochemical alterations occurring in urine as a result of dioxin toxicity. Urine samples were collected from Czech chemical workers ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.10.031
更新日期：2014-10-15 00:00:00
abstract：:Cadmium specifically modify amine metabolism at the central nervous system and pituitary hormone secretions. Thus, the physiological functions controlled by these hormones can be modulated by cadmium. This xenobiotic is associated with deleterious effects on the gonadal function and with changes in the secretory patte...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/s0378-4274(99)00159-9
更新日期：1999-11-22 00:00:00
abstract：:Chloroform-induced toxicity in rodents depends on oral dose regimen. We evaluated the absorption and tissue dosimetry of chloroform after gavage administration in various vehicles to male Fischer 344 rats and female B6C3F1 mice. Animals received a single dose of chloroform in corn oil, water, or aqueous 2% emulphor at...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(97)00023-4
更新日期：1997-05-16 00:00:00
abstract：:Impairment in cholinergic systems is a highly consistent finding in human dementia. Among cholinergic markers, marked decreases in nicotine binding have been most consistently observed in the telencephalic regions of demented patients and are thought to contribute to the cognitive deficits associated with ageing and a...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/s0378-4274(01)00502-1
更新日期：2002-02-28 00:00:00
abstract：:The phthalates di(2-ethylhexyl)phthalate (DEHP) and di-n-butyl phthalate (DBP) are environmental contaminants with significant human exposures. Both compounds are known reproductive toxins in rodents and DEHP also induces rodent hepatocarcinogenesis in a process believed to be mediated via the peroxisome proliferator-...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2005.11.001
更新日期：2006-06-01 00:00:00
abstract：:In this study we evaluated the rat Leydig cell carcinoma cell line R2C and the human adrenocorticocarcinoma cell line H295R for their suitability as in vitro screening tools for potential interference of xenobiotics with aromatase activity. A 24h exposure to prochloraz (PRO), fadrozole (FAD) and epoxyconazole (EPO) re...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2003.10.002
更新日期：2004-01-15 00:00:00
abstract：:Fusarenon-X (FX), a type B trichothecene mycotoxin, is mainly produced by Fusarium crookwellense, which occurs naturally in agricultural commodities, such as wheat and barley. FX has been shown to exert a variety of toxic effects on multiple targets in vitro. However, the embryonic toxicity of FX in vivo remains uncle...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.06.843
更新日期：2014-08-17 00:00:00
abstract：:Molecular epidemiologic research involves the identification of relations between previous exposure to some putative causative agent and subsequent biological effects in a cluster of individuals in populations. There is intensive current research in the field of molecular epidemiology, and this research has a direct i...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(95)03594-x
更新日期：1995-12-01 00:00:00
abstract：:The behavioral effects of concurrent maternal exposure to restraint stress and perfluorooctane sulfonate (PFOS) were assessed in the offspring of mice at 3 months of age. Plug positive females were divided into two groups. Animals were given by gavage 0 and 6mg PFOS/kg/day on gestation days 12-18. One-half of the anim...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2007.05.006
更新日期：2007-07-10 00:00:00
abstract：:It is known in humans and mouse models, that drinking water exposures to arsenite (As+3) leads to immunotoxicity. Previously, our group showed that certain types of immune cells are extremely sensitive to arsenic induced genotoxicity. In order to see if cells from different immune organs have differential sensitivitie...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2016.09.008
更新日期：2016-11-16 00:00:00
abstract：:Benzidine dihydrochloride administered in water at 0, 30, 60, 120, 200 or 400 ppm to 1664 mice induced a total of 368 hepatocellular carcinomas, of which 34 or 9.2% metastasized to the lungs. Liver tumors which were larger and heavier were more prone to metastasize and all that metastasized contained areas of prominen...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(80)90042-9
更新日期：1980-12-01 00:00:00
abstract：:The color additive, amaranth, was given in the diet to provide dietary levels of 0 (control), 0.03, 0.09 and 0.27%, from 5 weeks of age in F0 generation mice to 9 weeks of age in F1 generation mice, and some reproductive, developmental and behavioral parameters were measured. There was no effect on the parameters of l...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(92)90290-z
更新日期：1992-05-01 00:00:00
abstract：:The changes in hepatic metallothionein (MT) and glutathione levels and cadmium distribution were investigated 72 hr after a subcutaneous administration of 1.5 mg Cd2+/kg as CdCl2H2O to normal and partially hepatectomized rats. Partial hepatectomy had no effect on native metallothionein content. Cadmium and MT content ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(82)90195-3
更新日期：1982-06-01 00:00:00
abstract：:The toxic and teratogenic effects of 4 organophosphorus compounds (phenyl saliginen cyclic phosphate (PSCP), leptophos-oxon (LPTO), tri-o-tolyl phosphate (TOTP), and paraoxon (PXN] were investigated in the embryos of 3 species of frogs. Developmental abnormalities were observed in surviving embryos of each of the 3 sp...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(85)90163-8
更新日期：1985-08-01 00:00:00
abstract：:In this paper, the difficulties of genetic screening of occupationally exposed subjects for the evaluation of retrospective, and prospective, health risk assessments is illustrated with reference to glutathione S-transferase (GST) function. Individual differences in the magnitude and half-life of adduct levels, derive...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(02)00191-1
更新日期：2002-08-05 00:00:00
abstract：:The effect of melatonin on potassium cyanide-induced neurotoxicity was investigated in vivo. The ED50 value of potassium cyanide, as measured by induction of tonic and clonic seizures, was significantly increased by 1.5- or 1.8-fold by s.c. preinjection of melatonin (20, 100 or 345 mg/kg) in mice. The preventive effec...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(96)03671-5
更新日期：1996-09-01 00:00:00
abstract：:Bisphenol A (BPA) has been acknowledged as an estrogenic chemical able to interact with human estrogen receptors (ER). Many lines of evidence reveal that BPA has an impact as an endocrine disruptor even at low doses. However, its binding to ER and hormonal activity is extremely weak, making the intrinsic significance ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2006.08.012
更新日期：2006-12-01 00:00:00
abstract：:Lithocholic acid (LCA) is both a secondary bile acid and a vitamin D receptor (VDR) ligand. The VDR is activated by 1,25-dihydroxy vitamin D3 and plays an important role in maintaining integrity of the intestinal mucosal barrier. LCA can also substitute for vitamin D to carry out the in vivo functions of vitamin D. Ho...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2019.08.024
更新日期：2019-11-01 00:00:00
abstract：:Octamethylcyclotetrasiloxane (D4) is a low-molecular-weight volatile cyclic siloxane, primarily used as an intermediate in the production of some widely-used industrial and consumer silicone based polymers and may be present as a component in a variety of consumer products. A global "harmonized" risk assessment was co...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2017.05.019
更新日期：2017-10-20 00:00:00
abstract：:Benzophenone-3 (2-hydroxy-4-methoxybenzophenone, BZ-3) is a UV absorber that is used extensively in medicine, cosmetics and industry as a sunscreen and color fastener. Exposure to the chemical is through the dermal and oral route. Bioavailability of the chemical absorbed through the skin is different from that seen th...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(94)90101-5
更新日期：1994-08-01 00:00:00
abstract：:The aim of this study was to establish an air-liquid interface (ALI) culture of precision-cut lung slices (PCLS) for direct exposure of lung cells to gaseous contaminants. Nitrogen dioxide (NO(2)) and ozone (O(3)) were selected as model gas compounds. Acute pro-inflammatory and toxic effects of NO(2) and O(3) on live ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2010.04.004
更新日期：2010-07-01 00:00:00
abstract：:To clarify a possible mechanism of zinc (Zn)-induced tolerance to cadmium (Cd) toxicity on bone formation, femurs from 9-day-old chick embryos were cultured for 6 days by the roller-tube method in the presence of Cd (2, 4 or 9 microM) and/or Zn (60 microM). Zn prevented a decrease in bone growth caused by Cd at 4 and ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(88)90149-x
更新日期：1988-11-01 00:00:00
