Differential sensitivities of bone marrow, spleen and thymus to genotoxicity induced by environmentally relevant concentrations of arsenite.

abstract：:Fe(3)O(4) magnetic nanoparticles (MNPs) coated with 2,3-dimercaptosuccinnic acid (DMSA) are considered to be a promising nanomaterial with biocompatibility. In the present study, the effects of DMSA-coated Fe(3)O(4) MNPs on the expression of all identified mouse genes, which regulate various cellular biological proces...

journal_title：Toxicology letters

authors： Liu Y,Chen Z,Gu N,Wang J

更新日期：2011-08-28 00:00:00

abstract：:Due to the specific antimicrobial activity of silver nanoparticles (AgNPs), they are widely used in wound dressings, coatings in medical devices and household products. In spite of the well-documented genotoxicity of AgNPs, the molecular mechanisms of relieving AgNP-induced DNA damage stress remain poorly understood. ...

journal_title：Toxicology letters

authors： Wang D,Yang H,Zhou Z,Zhao M,Chen R,Reed SH

更新日期：2018-05-15 00:00:00

abstract：:This paper compares two methods for global optimization of physiologically based toxicokinetic models: Monte Carlo optimization, which searches randomly for the optimum; and the simplex method, which updates systematically an array of parameter values. Two measures of goodness-of-fit are also contrasted: criterion fun...

journal_title：Toxicology letters

authors： Woodruff TJ,Bois FY

更新日期：1993-08-01 00:00:00

abstract：:Nitropyrene (1-NP) is classified as Group 2B carcinogen and is one of the main components of diesel exhaust particles (DEP), which are generated from incomplete combustion of automobile engines to cause human cancer or inflammatory diseases. Although many reports on the mutagenesis or carcinogenesis of 1-NP have been ...

journal_title：Toxicology letters

authors： Park EJ,Park K

更新日期：2009-01-30 00:00:00

abstract：:This study aimed to evaluate bio-safety of magnetic chitosan nanogels as dual triggered drug carrier for doxorubicin through analysis of mitochondrial function. In the present study, chitosan/TPP nanogels containing magnetite nanoparticles (NPs) were prepared according to the ionotropic gelation method as novel pH-sen...

journal_title：Toxicology letters

authors： Sadighian S,Rostamizadeh K,Hosseini MJ,Hamidi M,Hosseini-Monfared H

更新日期：2017-08-15 00:00:00

abstract：:DNA-damaging agents are commonly used as anticancer therapeutics. Unfortunately, such drugs induced DNA damages as well as DNA repair are important in mediating drug resistance to cancer treatments. To evaluate changes in DNA repair proteins that occur in DNA damage agent treatment, we challenged human A549 lung adeno...

journal_title：Toxicology letters

authors： Shen YH,Chen BR,Cherng SH,Chueh PJ,Tan X,Lin YW,Lin JC,Chuang SM

更新日期：2011-09-10 00:00:00

abstract：:Chloral (trichloroacetaldehyde), the major metabolite of trichloroethylene (TCE), was investigated for its potential to form DNA-protein cross-links (DPX), a lesion produced by other aldehydes. Chloral did not form DPX in rat liver nuclei at concentrations up to 250 mM for 30 min at 37 degrees C, while chloroacetaldeh...

journal_title：Toxicology letters

authors： Keller DA,Heck HD

更新日期：1988-08-01 00:00:00

abstract：:(1) Local anaesthetics (LA) rely for their clinical actions on state-dependent inhibition of voltage-dependent sodium channels. (2) Single, batrachoxin-modified sodium channels in planar lipid bilayers allow direct observation of drug-channel interactions. Two modes of inhibition of single-channel current are observed...

journal_title：Toxicology letters

authors： French RJ,Zamponi GW,Sierralta IE

更新日期：1998-11-23 00:00:00

abstract：:Excess alcohol consumption during pregnancy could lead to fetal alcohol syndrome (FAS). However, the molecular mechanism leading to craniofacial abnormality, a feature of FAS, is still poorly understood. The cranial neural crest cells (NCCs) contribute to the formation of the craniofacial bones. Therefore, NCCs expose...

journal_title：Toxicology letters

authors： Zhang P,Wang G,Lin Z,Wu Y,Zhang J,Liu M,Lee KKH,Chuai M,Yang X

更新日期：2017-11-05 00:00:00

abstract：:Overexposure to manganese (Mn) has been known to induce neuronal death and neurodegenerative symptoms. However, the precise mechanisms underlying Mn neurotoxicity remain incompletely understood. In the present study, we established a Mn-exposed rat model and found that downregulation of wild type p53-induced phosphata...

journal_title：Toxicology letters

authors： Ma X,Han J,Wu Q,Liu H,Shi S,Wang C,Wang Y,Xiao J,Zhao J,Jiang J,Wan C

更新日期：2015-05-19 00:00:00

abstract：:Nitrogen mustard (HN-2), also known as mechlorethamine, is an alkylating anticancer agent as well as blister inducing chemical warfare agent. We evaluated the cytoprotective efficacy of amifostine, DRDE-07 and their analogues, and other antidotes of mustard agents against HN-2. Administration of 1 LD(50) of HN-2 (20mg...

journal_title：Toxicology letters

authors： Sharma M,Vijayaraghavan R,Gautam A

更新日期：2009-08-10 00:00:00

abstract：:Male mice (Q strain) received a single i.p. injection of 14 organophosphorus compounds, including 11 insecticides, administered on separate occasions. After a recovery period of 10 to 15 days, the cytogenic effects were analyzed in primary spermatocytes at diakinesis-metaphase I corresponding to the treatment of A4-B ...

journal_title：Toxicology letters

authors： Degraeve N,Chollet MC,Moutschen J

更新日期：1984-06-01 00:00:00

abstract：:1. General anesthesia is achieved by anesthetic action in the central nervous system (CNS). 2. Whereas amnesia and unconsciousness are due to anesthetic action in the brain, recent evidence suggests that immobility in response to a noxious stimulus is achieved by anesthetic effects in the spinal cord. The putative spi...

journal_title：Toxicology letters

authors： Antognini JF,Carstens E

更新日期：1998-11-23 00:00:00

abstract：:Pregnant rats were given di-n-butyltin dichloride (DBT) by gastric intubation at a dose of 0, 2.5, 5.0, 7.5 or 10.0 mg/kg on days 7-15 of pregnancy. Maternal toxicity occurred in the 7.5 and 10.0 mg/kg groups as evidenced by a significant increase in maternal death and decrease in food consumption and body weight gain...

journal_title：Toxicology letters

authors： Ema M,Itami T,Kawasaki H

更新日期：1991-11-01 00:00:00

abstract：:The effects of T-2 toxin on the in vitro mitogen responses and the antibody-producing ability of human peripheral blood lymphocytes were evaluated. T-2 toxin inhibited the mitogen response to concanavalin A (ConA) at a lower concentration (1.6 ng/ml) as compared to phytohemagglutinin (2.4 ng/ml) and pokeweed mitogen (...

journal_title：Toxicology letters

authors： Tomar RS,Blakley BR,De Coteau WE

更新日期：1988-02-01 00:00:00

abstract：:The effect of methyl mercury chloride (MeHgCl) on the chick sympathetic and sensory dorsal root ganglia was studied in a biological in vitro assay. These cultures were not affected by the addition of MeHg up to a concentration of 2 microM. However, after an addition of 4-5 microM MeHg the capability of the neurons to ...

journal_title：Toxicology letters

authors： Söderström S,Ebendal T

更新日期：1995-01-01 00:00:00

abstract：:The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most potent risk factor among tobacco-related carcinogens in lung cancer progression and outcomes. Although genetic mutations and chromosome instability have been detected in NNK-induced lung tumors, the oncogenic mechanisms o...

journal_title：Toxicology letters

authors： Park JE,Jang YL,Jang CY

更新日期：2017-11-05 00:00:00

abstract：:Even though compounds of nickel, arsenic, cobalt and cadmium are carcinogenic, their mutagenic potentials are rather weak. In contrast, they exert pronounced comutagenic effects, which may be explained by disturbances of different DNA repair systems. Thus, cobalt, arsenic, nickel and cadmium interfere with base and nu...

journal_title：Toxicology letters

authors： Hartwig A,Schwerdtle T

更新日期：2002-02-28 00:00:00

abstract：:Modulation of the cytochrome P450 (CYP) monooxygenase system by cadmium was investigated in male, adult DBA/2J mice treated with a single dose (16 micromol/kg body weight, i.p.) of cadmium chloride (CdCl2). Total CYP content of liver and kidney microsomes decreased maximally (56% and 85%, respectively) 24 and 18 h, re...

journal_title：Toxicology letters

authors： Abu-Bakar A,Satarug S,Marks GC,Lang MA,Moore MR

更新日期：2004-03-21 00:00:00

abstract：:Shikonin, a natural red colorant, is widely used for food garnishment and cosmetic ingredient in the world. Shikonin also possesses a variety of pharmacological actions, including anti-inflammation and anti-cancer activities. However, little is known about its effects on the UDP-glucuronosyltransferases (UGT) activity...

journal_title：Toxicology letters

authors： Cheng Y,Tang S,Chen A,Zhang Y,Liu M,Wang X

更新日期：2019-09-15 00:00:00

abstract：:Dichloroacetic acid (DCA) is a complete hepatocarcinogen and tumor promoter in the male B6C3F1 mouse. Published reports indicate that the compound is non-genotoxic. This study examines possible non-genotoxic (epigenetic) mechanisms by which DCA elicits its carcinogenic response. Correlative biochemical, pathologic and...

journal_title：Toxicology letters

authors： Carter JH,Carter HW,DeAngelo AB

更新日期：1995-11-01 00:00:00

abstract：:Treatment of pregnant C57BL/6N mice with 2,3,7,8-tetrachlorodibenzofuran (TCDF) (0, 250, 500, and 1000 micrograms/kg on gestation day 10 or 0, 10, 30, 50, and 100 micrograms/kg on gestation days 10-13) results in dose-related increases in isolated cleft palates and hydronephrotic kidneys in the offspring. TCDF is tera...

journal_title：Toxicology letters

authors： Weber H,Lamb JC,Harris MW,Moore JA

更新日期：1984-02-01 00:00:00

abstract：:Chemical warfare agents, such as soman, and pesticides, such as chlorpyrifos, dichlorvos or malathion, are toxic organophosphorous compounds (OPCs) that are readily absorbed by the skin. Decontamination using solvents or surfactants may modify the cornified layer - the skin's main barrier against xenobiotic penetratio...

journal_title：Toxicology letters

authors： Mircioiu C,Voicu VA,Ionescu M,Miron DS,Radulescu FS,Nicolescu AC

更新日期：2013-05-23 00:00:00

abstract：:Di-(2-ethylhexyl)-phthalate (DEHP) is a phthalate ester that binds peroxisome proliferator-activated receptor α (PPARα) to induce proliferation of peroxisomes and regulate the expression of specific target genes. The question of whether the effect of DEHP on female reproductive processes is mediated via PPARα-dependen...

journal_title：Toxicology letters

authors： Kawano M,Qin XY,Yoshida M,Fukuda T,Nansai H,Hayashi Y,Nakajima T,Sone H

更新日期：2014-08-04 00:00:00

abstract：:Inorganic arsenic (As), the most toxic form of As found in water and food, is considered a human carcinogen. Numerous studies show its systemic toxicity, describing pathologies associated with chronic exposure. The main pathway of exposure to inorganic As is oral, but many of the events that occur during its passage t...

journal_title：Toxicology letters

authors： Chiocchetti GM,Vélez D,Devesa V

更新日期：2018-04-01 00:00:00

abstract：:The utility of HepaRG cells as an in vitro cell-based assay system for assessing drug-induced liver injury (DILI) risk was investigated. Seventeen DILI-positive and 15 DILI-negative drugs were selected for the assay. HepaRG cells were treated with each drug for 24h at concentrations that were 1.6-, 6.3-, 25-, and 100-...

journal_title：Toxicology letters

authors： Tomida T,Okamura H,Satsukawa M,Yokoi T,Konno Y

更新日期：2015-07-02 00:00:00

abstract：:A wholesomeness feeding study was carried out in mice fed equal amounts of cod or redfish, comprising 45% of the diet. Three groups of animals received either irradiated [1.75 kGy (175 krad)] fish, non-irradiated fish or stock ration. A 90-day subchronic study, a multigeneration reproduction, a dominant lethality and ...

journal_title：Toxicology letters

authors： van Petten LE,Calkins JE,McConnell RF,Gottschalk HM,Elias PS

更新日期：1980-12-01 00:00:00

abstract：:Metallothionein (MT) is inducible by various stimuli such as metals and physiological stress. Although elevated MT expression in certain type of tumors has been reported, there are few data available on the roles of MT in tumor formation. In this study, we immunohistochemically examined MT expression in gluthathione S...

journal_title：Toxicology letters

authors： Sawaki M,Enomoto K,Hattori A,Tsuzuki N,Sawada N,Mori M

更新日期：1999-07-30 00:00:00

abstract：:Recently, we reported that silver nanoparticles (AgNPs) induced reactive oxygen species (ROS) generation and the resultant oxidative stress contributes to the cell damage associated with AgNPs. 8-Oxoguanine (8-oxoG) is sensitive marker of ROS-induced DNA damage. 8-Oxoguanine DNA glycosylase 1 (OGG1) is an important DN...

journal_title：Toxicology letters

authors： Piao MJ,Kim KC,Choi JY,Choi J,Hyun JW

更新日期：2011-11-30 00:00:00

abstract：:Aromatic amines are metabolically activated into mutagenic compounds by both animal and plant systems. The 4-nitro-o-phenylenediamine (NOP) is a well-known direct-acting mutagen whose mutagenic potential can be enhanced by plant metabolism; m-phenylenediamine (m-PDA) is converted to mutagenic products detected by the ...

journal_title：Toxicology letters

authors： Cortés-Eslava J,Gómez-Arroyo S,Villalobos-Pietrini R,Espinosa-Aguirre JJ

更新日期：2004-11-02 00:00:00