Abstract：
:The effects of T-2 toxin on the in vitro mitogen responses and the antibody-producing ability of human peripheral blood lymphocytes were evaluated. T-2 toxin inhibited the mitogen response to concanavalin A (ConA) at a lower concentration (1.6 ng/ml) as compared to phytohemagglutinin (2.4 ng/ml) and pokeweed mitogen (2.4 ng/ml). Maximum inhibition was observed when the toxin was present during the first 8 h; however, the cultures were not refractory to inhibition until 48 h after culture initiation. The antibody-producing ability was inhibited by T-2 toxin concentrations of greater than or equal to 3.2 ng/ml. T-2 toxin did not induce or interfere with the generation of suppressor cells by ConA. The results of this study indicate that various lymphocyte subpopulations have different susceptibilities to T-2 toxin. The activation process associated with lymphocyte proliferation appears to be one of the most sensitive time periods.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Tomar RS,Blakley BR,De Coteau WEdoi
10.1016/0378-4274(88)90151-8subject
Has Abstractpub_date
1988-02-01 00:00:00pages
109-17issue
2eissn
0378-4274issn
1879-3169pii
0378-4274(88)90151-8journal_volume
40pub_type
杂志文章abstract：:The aim of this study was to determine the toxicokinetics and some effects of 1,1,1-trifluoroethane (HFC-143a) in humans. Nine male volunteers were experimentally exposed to 500ppm HFC-143a for 2h during light physical exercise (50W) in an exposure chamber. Blood, urine and exhaled air were sampled before, during and ...
journal_title：Toxicology letters
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更新日期：2007-08-01 00:00:00
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更新日期：1995-12-01 00:00:00
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journal_title：Toxicology letters
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更新日期：1990-11-01 00:00:00
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更新日期：1993-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1992-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-05-15 00:00:00
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pub_type： 杂志文章
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更新日期：1988-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：1982-12-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：2012-05-05 00:00:00
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更新日期：1986-10-01 00:00:00
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journal_title：Toxicology letters
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更新日期：2014-01-13 00:00:00
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journal_title：Toxicology letters
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更新日期：1989-03-01 00:00:00
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更新日期：1999-12-20 00:00:00
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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更新日期：2007-01-10 00:00:00
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更新日期：1996-10-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2012-07-20 00:00:00
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journal_title：Toxicology letters
pub_type： 共识发展会议,杂志文章
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更新日期：2019-09-01 00:00:00
abstract：:Several incidences of reduction in the fertility (sperm count) have been reported in India and worldwide as well. Adulteration of food and consumption of adulterated mustard oil with argemone oil (AO) are presumed to be the factors for reduction in sperm count. In the present study we have studied the exfoliation of g...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2009.01.006
更新日期：2009-04-25 00:00:00
abstract：:The effect of chlordimeform (CDM) treatment on the hepatic microsomal drug metabolizing enzymes was examined in male and female rats following either acute or repeated treatment. After acute administration of chlordimeform (100 mg/kg, i.p., 1 hour before killing) differential effects were observed in various parameter...
journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1983-08-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(97)00042-8
更新日期：1997-07-21 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(97)00087-8
更新日期：1997-12-01 00:00:00
abstract：:Sister-chromatid exchanges (SCEs) were analyzed from peripheral lymphocyte cultures of 8 men and 16 women who had been exposed to environmental cadmium (Cd), and 6 controls. Average Cd concentrations in blood of the Cd-polluted group were 8.9 micrograms/l for men and 10.0 micrograms/l for women. These were no signific...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(86)90120-7
更新日期：1986-09-01 00:00:00
abstract：:Aluminum (Al) is a toxic metal, and excessive Al accumulation causes immunosuppression. Deferiprone (DFP) is a well-known chelator and used in dialysis patients for removing Al from tissues. The present study aimed to investigate whether DFP treatment can attenuate immunotoxicity induced by aluminum chloride (AlCl3) i...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2018.01.007
更新日期：2018-03-15 00:00:00
