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Induction of pro-inflammatory signals by 1-nitropyrene in cultured BEAS-2B cells.

Abstract：

:Nitropyrene (1-NP) is classified as Group 2B carcinogen and is one of the main components of diesel exhaust particles (DEP), which are generated from incomplete combustion of automobile engines to cause human cancer or inflammatory diseases. Although many reports on the mutagenesis or carcinogenesis of 1-NP have been released, non-carcinogenic toxicities of 1-NP have not been widely studied. In this study, induction of pro-inflammatory signals by 1-NP was investigated using cultured human bronchial epithelial cells, BEAS-2B. By using microarray analysis and RT-PCR technique, it was found that 1-NP induced the expression of genes related to the pro-inflammatory responses such as pentaxin, IL-1beta, IL-6, IL-8, C-X-C motif ligand 2 (CXCL2), and TNF-alpha. 1-NP was also found to induce ROS generation and intracellular GSH decrease. It suggested that 1-NP may be a pivotal component of DEP to cause inflammatory diseases.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Park EJ,Park K

doi

10.1016/j.toxlet.2008.10.028

subject

Has Abstract

pub_date

2009-01-30 00:00:00

pages

126-33

issue

2

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(08)01329-5

journal_volume

184

pub_type

杂志文章

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