Downregulation of Nrf2/HO-1 pathway and activation of JNK/c-Jun pathway are involved in homocysteic acid-induced cytotoxicity in HT-22 cells.

abstract：:New findings on Bisphenol A (BPA) contents in thermal printing papers, and receipts, in g/kg concentrations and on its dermal uptake (up to 60%) prompted us to assess the risk arising from dermal exposure. Using physiologically based toxicokinetic modelling, we simulated concentrations in blood, in liver and kidney, t...

journal_title：Toxicology letters

authors： Mielke H,Partosch F,Gundert-Remy U

更新日期：2011-07-28 00:00:00

abstract：:This study tested a hypothesis that soybean lipoxygenase (SLO), a model enzyme, may be capable of generating a glutathione (GSH) conjugate(s) from p-aminophenol (PAP). Horseradish peroxidase was employed as a positive control. GSH depletion or an increase in the absorption at 327 nm with time due to GS-PAP formation w...

journal_title：Toxicology letters

authors： Yang X,Kulkarni AP

更新日期：2000-01-05 00:00:00

abstract：:Rats were treated with LiCl or RbCl in drinking water for 65 days. Spleen cells from both treated groups exhibited significantly greater proliferative responses to lipopolysaccharide (LPS) than those from untreated controls. Responses to concanavalin A (Con A) were not affected. Cytotoxic activities of natural killer ...

journal_title：Toxicology letters

authors： Jones JM,Yeralan O,Hines G,Maher M,Roberts DW,Benson RW

更新日期：1990-07-01 00:00:00

abstract：:Oral intubation of 50 and 100 mg/kg acephate inhibited brain acetylcholinesterase (AChE) activity by 45% and 56%, and reduced basal luteinizing hormone (LH) concentration by 29% and 25% after 4 h in white-footed mice (Peromyscus leucopus noveboracensis). Dietary exposure to 25, 100, and 400 ppm acephate for 5 days sub...

journal_title：Toxicology letters

authors： Rattner BA,Michael SD

更新日期：1985-01-01 00:00:00

abstract：:3-methyladenine DNA glycosylase (AlkD) belongs to a new family of DNA glycosylases; it initiates repair of cytotoxic and promutagenic alkylated bases (its main substrates being 3-methyladenine and 7-methylguanine). The modification of the comet assay (single cell gel electrophoresis) using AlkD enzyme thus allows asse...

journal_title：Toxicology letters

authors： Hašplová K,Hudecová A,Magdolénová Z,Bjøras M,Gálová E,Miadoková E,Dušinská M

更新日期：2012-01-05 00:00:00

abstract：:The study was designed to conduct human in vivo and in vitro studies on the gastrointestinal absorption of nanoparticles, using titanium dioxide as a model compound, and to compare nanoparticle behaviour with that of larger particles. A supplier's characterisation data may not fully describe a particle formulation. Mo...

journal_title：Toxicology letters

authors： Jones K,Morton J,Smith I,Jurkschat K,Harding AH,Evans G

更新日期：2015-03-04 00:00:00

abstract：:Besides hepatotoxicity, paracetamol may exert nephrotoxic effects in experimental animals and man. The present study in rats shows that cholestyramine given 4 and 24 h after paracetamol provided protection against both hepato- and nephrotoxicity; this was evidenced by reduced increments in plasma enzyme activities (SD...

journal_title：Toxicology letters

authors： Siegers CP,Möller-Hartmann W

更新日期：1989-05-01 00:00:00

abstract：:Administration of [14C]chlorferron in a single oral dose of 0.5 and 20 mg/kg body weight to female rats resulted in a urinary excretion of greater than 74% of the given dose during the first 24 h. Approx. 8% of the dose was eliminated in faeces within 7 days. 7 days after dosing, very low levels of [14C]chlorferron-de...

journal_title：Toxicology letters

authors： Malik JK,Lay JP,Klein W,Korte F

更新日期：1981-03-01 00:00:00

abstract：:Chronic feeding of male Wistar rats with food containing hexachlorobenzene (HCB) at 17.5 mmol/kg induced elevation of serum amino-transferases and bilirubin content, increase of microsomal cytochrome P-450 concentration, and decrease of 5'-nucleotidase, K+,Na+- and Mg2+-adenosine triphosphatase activities in liver pla...

journal_title：Toxicology letters

authors： Nikolaev V,Naydenova E,Kerimova M,Dimov S,Ivanov E

更新日期：1986-09-01 00:00:00

abstract：:Male C57B1/6N mice, 8-10 weeks old were given a single oral dose of 0, 1.0 or 3.0 mg/kg body weight of trimethyltin hydroxide (TMT). Levels of ornithine decarboxylase (ODC) activity were measured in several brain areas, 1, 2 and 7 days later. The lower dose of TMT produced a decrease of ODC in the caudate nucleus and ...

journal_title：Toxicology letters

authors： Ali SF,Newport GD,Slikker W Jr,Bondy SC

更新日期：1987-03-01 00:00:00

abstract：:The adverse effects on the immune system resulting from acute and subchronic exposure to immunotoxic compounds can be divided into the following three categories. One is the tissue manifestations induced by either immunosuppressive or immunomodulative compounds through the interactions of the drug or its metabolites w...

journal_title：Toxicology letters

authors： Udaka K

更新日期：1992-12-01 00:00:00

abstract：:Male Swiss OF1 mice received a single oral dose of either 80 mg/kg hexachloro-1,3-butadiene (HCBD) or 40 mg/kg methyl mercury (MeHg). Examination of cryostat kidney sections stained for alkaline phosphatase (APP) revealed damage to about 50% of the proximal tubules after 8 h. Treatment with the organic anion transport...

journal_title：Toxicology letters

authors： Ban M,de Céaurriz J

更新日期：1988-01-01 00:00:00

abstract：:Potentiality of a protective effect of methionine against hepatotoxic action of vinyl chloride (VC) was assessed on rats, induced with phenobarbital and thereafter exposed to 50 000 ppm VC for 5 h. This extremely high dosage of VC warranted the appearance of drastic symptoms of liver injury in the course of 20 h poste...

journal_title：Toxicology letters

authors： Wisniewska-Knypl JM,Sokal JA,Klimczak J,Dajniak A,Bogdanikowa B

更新日期：1981-05-01 00:00:00

abstract：:A comparison of the effects produced by size-fractionated tire particles (TP10 and TP2.5) and similar-sized urban particulate matter (PM10 and PM2.5), collected in Milan in 2007, on the lungs of mice has been performed. The focus is on early acute lung responses following intratracheal instillation of aerosolized part...

journal_title：Toxicology letters

authors： Mantecca P,Farina F,Moschini E,Gallinotti D,Gualtieri M,Rohr A,Sancini G,Palestini P,Camatini M

更新日期：2010-10-05 00:00:00

abstract：:Health impacts of inhalation exposure to engineered nanomaterials have attracted increasing attention. In this paper, integrated analytical techniques with high sensitivity were used to study the brain translocation and potential impairment induced by intranasally instilled copper nanoparticles (CuNPs). Mice were expo...

journal_title：Toxicology letters

authors： Bai R,Zhang L,Liu Y,Li B,Wang L,Wang P,Autrup H,Beer C,Chen C

更新日期：2014-04-07 00:00:00

abstract：:The HER2 pathway plays a pivotal role in cell proliferation and differentiation, while the receptor overexpression caused by amplification of HER2 gene is associated with the growth of several tumors. Previously published clinical trials have demonstrated that antibody-conjugated drugs (ADCs) remarkably improved clini...

journal_title：Toxicology letters

authors： Jiang J,Li S,Shan X,Wang L,Ma J,Huang M,Dong L,Chen F

更新日期：2020-05-15 00:00:00

abstract：:Protein S-glutathionation has been demonstrated to be one of the cellular responses under oxidative stress and may be involved in many cellular metabolisms. In this study, the effect of redox cycling bipyridylium compounds, paraquat and diquat, on this protein modification was investigated. Male Sprague-Dawley rats we...

journal_title：Toxicology letters

authors： Lii CK,Wang ST,Chen HW

更新日期：1996-02-01 00:00:00

abstract：:Activity of beta-glucuronidase and cathepsin-D were studied in brain, spinal cord and sciatic nerves of rats at 24 h or 10 days after daily i.p. administration of 50 mg/kg acrylamide. The activities of beta-glucuronidase and cathepsin-D in brain, spinal cord and sciatic nerves remained unaffected on single exposure bu...

journal_title：Toxicology letters

authors： Srivastava SP,Srivastava SP,Seth PK

更新日期：1984-08-01 00:00:00

abstract：:This objective of this study was to investigate the toxicogenomics and the spatial regulation of global gene expression profiles elicited by endoplasmic reticulum (ER) stress inducer tunicamycin (TM) in mouse small intestine and liver as well as to identify TM-modulated nuclear factor-E2-related factor 2 (Nrf2)-depend...

journal_title：Toxicology letters

authors： Nair S,Xu C,Shen G,Hebbar V,Gopalakrishnan A,Hu R,Jain MR,Liew C,Chan JY,Kong AN

更新日期：2007-01-10 00:00:00

abstract：:Impairment in cholinergic systems is a highly consistent finding in human dementia. Among cholinergic markers, marked decreases in nicotine binding have been most consistently observed in the telencephalic regions of demented patients and are thought to contribute to the cognitive deficits associated with ageing and a...

journal_title：Toxicology letters

authors： Zanardi A,Leo G,Biagini G,Zoli M

更新日期：2002-02-28 00:00:00

abstract：:A single intraperitoneal injection of cadmium chloride (CdCl2, 0.32 mg/kg body weight) was administered to 15 adult female palm squirrels (Funambulus pennanti (Wroughton] and the hypothalamic 5-hydroxytryptamine (5-HT), noradrenaline (NA) and dopamine (DA) levels were quantified on the 1st, 7th and 40th day. 5-HT leve...

journal_title：Toxicology letters

authors： Shrivastava VK,Sathyanesan AG

更新日期：1988-05-01 00:00:00

abstract：:Mercury(II) ions are known to accumulate in the kidney and their effect upon the renin-angiotensin system has also been described. The question, however, whether mercury(II) also exerts direct effect on the juxtaglomerular cells (JGC) to induce renin release remained to be answered. Suspension of isolated glomeruli wa...

journal_title：Toxicology letters

authors： Kozma L,Lenkey A,Varga E,Gomba S

更新日期：1996-04-01 00:00:00

abstract：:For the past 10 years we have focused on the development of antisense treatments against viral infections such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV). We have demonstrated that phosphorothioate oligomers have in vitro anti-HIV activities and in vivo anti-HBV activity. In vitro anti-HIV activ...

journal_title：Toxicology letters

authors： Matsukura M,Koike K,Zon G

更新日期：1995-12-01 00:00:00

abstract：:The European Commission has decided on harmonized classifications for a large number of individual chemicals according to its own directive for classification and labeling of dangerous substances. We have compared the harmonized classifications for acute oral toxicity to the acute oral toxicity data available in the R...

journal_title：Toxicology letters

authors： Rudén C,Hansson SO

更新日期：2003-09-30 00:00:00

abstract：:Monosodium glutamate (MSG) was administered to adult male mice for 6 d at dose levels of 2, 4 and 8 mg/g b.w. Dose levels of 4 and 8 mg/g MSG resulted in significant changes in serum total lipids, triglycerides, phospholipids, free fatty acids and blood glucose 31 d after cessation of exposure. Administration of 2 mg/...

journal_title：Toxicology letters

authors： Ahluwalia P,Malik VB

更新日期：1989-02-01 00:00:00

abstract：:Chloroacetonitrile (CAN) is a disinfection by-product of chlorination of drinking water. The present study was designed to investigate the potential adverse effects of maternal exposure to CAN on fetal liver in mice. Based on an initial dose-response experiment, CAN (25mg/(kgday)) was given orally to pregnant mice at ...

journal_title：Toxicology letters

authors： Abdel-Naim AB,Nagy AA,Mohamadin AM,El-Mazar HM,Ahmed AE

更新日期：2009-10-28 00:00:00

abstract：:Pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine pesticide, chlordecone (CD), stimulated biliary excretion of exogenous cholesterol (CH) up to 3-fold. Increased biliary excretion occurred without changes in hepatic ATP-binding cassette transporter G8 (ABCG8) of the bile canaliculus or ...

journal_title：Toxicology letters

authors： Scheri RC,Lee J,Barofsky DF,Curtis LR

更新日期：2009-12-01 00:00:00

abstract：:Identification of genetic polymorphisms responsible for reduced DNA repair capacity may allow better cancer prevention. We examined whether variations in genes involved in base-excision (hOGG1, XRCC1) and double strand break (XRCC3) DNA repair contribute to inter-individual differences in genotoxic effects induced in ...

journal_title：Toxicology letters

authors： Mateuca R,Aka PV,De Boeck M,Hauspie R,Kirsch-Volders M,Lison D

更新日期：2005-04-10 00:00:00

abstract：:Benzene is an occupational and environmental toxicant. The major health concern for humans is acute myelogenous leukemia. To exert its toxic effects, benzene must be metabolized by cytochrome P450 to phenol and subsequently to catechol and hydroquinone. Previous research has implicated CYP2E1 in the metabolism of phen...

journal_title：Toxicology letters

authors： Powley MW,Carlson GP

更新日期：2001-12-15 00:00:00

abstract：:Exposure of C57Bl mice to 10 ppm benzene (the current occupational exposure limit) for 6 h/day, 5 days/week causes a progressive depression in the in vitro colony forming ability of one of the erythroid progenitor cells, the colony-forming unit-erythroid (CFU-E). Colony growth of cells from exposed mice was only 5% of...

journal_title：Toxicology letters

authors： Baarson KA,Snyder CA,Albert RE

更新日期：1984-03-01 00:00:00