Acid hydrolases in brain, spinal cord and sciatic nerves of acrylamide-intoxicated rats.

Abstract:

:Activity of beta-glucuronidase and cathepsin-D were studied in brain, spinal cord and sciatic nerves of rats at 24 h or 10 days after daily i.p. administration of 50 mg/kg acrylamide. The activities of beta-glucuronidase and cathepsin-D in brain, spinal cord and sciatic nerves remained unaffected on single exposure but increased significantly in these tissues on administration of the neurotoxin for 9 consecutive days. The increase in the activity of beta-glucuronidase and cathepsin-D was more marked in sciatic nerves, than brain or spinal cord. These results suggest that cathepsin-D and beta-glucuronidase may be involved in the acrylamide-induced degeneration of nervous tissues and can serve as useful markers for the detection of chemical-induced neuropathies.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Srivastava SP,Srivastava SP,Seth PK

doi

10.1016/0378-4274(84)90068-7

subject

Has Abstract

pub_date

1984-08-01 00:00:00

pages

211-5

issue

2

eissn

0378-4274

issn

1879-3169

pii

0378-4274(84)90068-7

journal_volume

22

pub_type

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