Rat liver plasma membrane damage in hexachlorobenzene intoxication and its potentiation by ethanol.

abstract：:The people studied were male volunteers without occupational and dietary exposure to PAH: 27 smokers (10 cigarettes or more) and 27 non-smokers matched for age and socio-professional category. For each person, all the 24h voided urine samples were reassembled in a single sample. 1-Hydroxypyrene (1-OHPy) and 3-hydroxyb...

journal_title：Toxicology letters

authors： Lafontaine M,Champmartin C,Simon P,Delsaut P,Funck-Brentano C

更新日期：2006-04-10 00:00:00

abstract：:A quantitative high-content screening (HCS) was suggested for the real-time monitoring of drug-induced mitochondrial dysfunction-mediated hepatotoxicity. This HCS is very advantageous in that it allows simultaneous observation of drug-induced activations of hepatotoxic pathways using hypermulticolor cellular imaging. ...

journal_title：Toxicology letters

authors： Kim JA,Han E,Eun CJ,Tak YK,Song JM

更新日期：2012-10-17 00:00:00

abstract：:The potential adverse effects of hazardous waste incinerators (HWI) continue to be a subject of worry. The construction of the first and up till now only HWI in Spain finished in 1999. Twenty-six subjects employed at this HWI were divided into three groups: plant, laboratory and administration. Plasma analyses of HCB,...

journal_title：Toxicology letters

authors： Carmen Agramunt M,Domingo A,Domingo JL,Corbella J

更新日期：2003-12-15 00:00:00

abstract：:A low-Mr copper (Cu) and zinc (Zn)-binding protein was present in the liver of a control water lizard Triturus pyrrhogaster. Cadmium (Cd) accumulated in the liver of the animals after intramuscular injections of Cd salt and was bound to Cu- and Zn-binding protein of a single isoform that had properties characteristic ...

journal_title：Toxicology letters

authors： Suzuki KT,Akitomi H,Kawamura R

更新日期：1984-05-01 00:00:00

abstract：:Mercury, one of the widespread pollutants in the world, induces oxidative stress and dysfunction in many cell types. Alveolar type II epithelial cells are known to be vulnerable to oxidative stress. Alveolar type II epithelial cells produce and secrete surfactants to maintain morphological organization, biophysical fu...

journal_title：Toxicology letters

authors： Lu TH,Chen CH,Lee MJ,Ho TJ,Leung YM,Hung DZ,Yen CC,He TY,Chen YW

更新日期：2010-05-04 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN) and depletion of striatal dopamine (DA), leading to a range of motor symptoms, including resting tremor, rigidity, bradykinesia and postural abnormalities. The neurotoxin (MPTP) and its active metabol...

journal_title：Toxicology letters

authors： Bernstein AI,O'Malley KL

更新日期：2013-05-23 00:00:00

abstract：:Dimethocaine (DMC), a synthetic derivative of cocaine, is distributed and consumed as "new psychoactive substance" (NPS) without any safety testing at the forefront. It is mainly metabolized by N-acetylation, N-deethylation or hydroxylation. Therefore, the aim of the presented study was to determine the human NAT and ...

journal_title：Toxicology letters

authors： Meyer MR,Lindauer C,Maurer HH

更新日期：2014-02-10 00:00:00

abstract：:Intraperitoneal injection of the iron-complex, ferric-nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage associated with oxidative damage in vivo. Fe-NTA induced a time-dependent decrease of several polyunsaturated fatty acids (PUFA), together with increased conjugated diene values and decreased cellula...

journal_title：Toxicology letters

authors： Deiana M,Aruoma OI,Rosa A,Crobu V,Casu V,Piga R,Dessi MA

更新日期：2001-09-15 00:00:00

abstract：:Exposure to polychlorinated biphenyls (PCBs) induce a broad spectrum of toxic effects in various organs including bone. The most susceptible age-groups to the toxic effects of PCBs are foetuses and infants. The aim of the present study was to quantitatively evaluate changes in bone geometry, mineral density and biomec...

journal_title：Toxicology letters

authors： Elabbas LE,Herlin M,Finnilä MA,Rendel F,Stern N,Trossvik C,Bowers WJ,Nakai J,Tuukkanen J,Viluksela M,Heimeier RA,Akesson A,Håkansson H

更新日期：2011-11-10 00:00:00

abstract：:As a main clinical feature of obstructive sleep apnea (OSA), intermittent hypoxia (IH) induces oxidative stress, leading to damage to a variety of organs, including kidney. Metallothionein (MT) is a potent antioxidant that protects kidney against oxidative damage. Our previous studies demonstrated that MT prevented IH...

journal_title：Toxicology letters

authors： Wu H,Zhou S,Kong L,Chen J,Feng W,Cai J,Miao L,Tan Y

更新日期：2015-01-22 00:00:00

abstract：:There have been many concerns about the possible adverse effects of thyroid hormone-disrupting chemicals in the environment. Because thyroid hormones are essential for regulating the growth and differentiation of many tissues, disruption of thyroid hormones during the neonatal period of an organism might lead to perma...

journal_title：Toxicology letters

authors： Fujimoto N,Kitamura S,Uramaru N,Miyagawa S,Iguchi T

更新日期：2018-04-01 00:00:00

abstract：:Exposure to cyanide from gari, a popular cassava food in West Africa, is implicated in the causation of ataxic polyneuropathy and amblyopia, but this has been questioned because cyanide was not detected in gari in a study. This study was carried out to determine if gari is a source of exposure to cyanide. Gari (150 g)...

journal_title：Toxicology letters

authors： Oluwole OS,Onabolu AO,Sowunmi A

更新日期：2002-09-05 00:00:00

abstract：:Nonylphenol (NP) is a representative endocrine disruptor that has an adverse effect on male reproduction and posses direct hazard to Sertoli cells, but the mechanism remains incompletely elucidated. In the present study, based on the structural comparability and high affinity between NP and membrane phospholipid molec...

journal_title：Toxicology letters

authors： Gong Y,Pan X,Huang Y,Gao Z,Yu H,Han X

更新日期：2008-12-15 00:00:00

abstract：:The present study was undertaken in an attempt to reconcile the seemingly conflicting observations that glutathione-dependent biotransformation of methyl parathion (O,O-dimethyl-O-(4-nitrophenyl)phosphorothionate) by hepatic supernatant or partially purified glutathione S-transferases occurs in vitro, but not to any s...

journal_title：Toxicology letters

authors： Huang YS,Sultatos LG

更新日期：1993-06-01 00:00:00

abstract：:Chlordecone is an organochlorine used in the 1970's as a pesticide in banana plantations. It has a long half-life in the soil and can potentially contaminate humans and animals through food. Chlordecone targets, and mainly accumulates in, the liver, leading to hepatomegaly and neurological signs in mammals. Chlordecon...

journal_title：Toxicology letters

authors： Tabet E,Gelu-Simeon M,Genet V,Lamontagne L,Piquet-Pellorce C,Samson M

更新日期：2018-12-15 00:00:00

abstract：:Sulfur mustard (SM) is a highly toxic chemical warfare agent, which produces blisters after skin contact. Treatment of SM-induced adverse health effects, such as cutaneous blistering, ulceration, and inflammation remains a challenging task. Antidotes or specific therapeutic measures are lacking. Some drugs (e.g. cyclo...

journal_title：Toxicology letters

authors： Wagner S,Lang S,Popp T,Schmidt A,Thiermann H,Steinritz D,Kehe K

更新日期：2019-09-15 00:00:00

abstract：:Norepinephrine-induced contractility and relaxation to acetylcholine of isolated aortas taken from normal and chronic alcoholic rats were measured. Similar experiments were performed adding serum from normal (NS) or alcoholic rats (AS), with or without norepinephrine and acetylcholine. Responses of normal and alcoholi...

journal_title：Toxicology letters

authors： Baños G,Lopez-Zetina P,Franco M

更新日期：1995-02-01 00:00:00

abstract：:The chronic toxic effects of chromium (2.6 mg/1) on the carbohydrate metabolism of a teleost fish, Channa punctatus were examined after 60 and 120 days of exposure. After 60 days the lactic acid content of blood and muscles was increased but liver lactic acid content decreased. Liver glycogen was also depleted. The ac...

journal_title：Toxicology letters

authors： Sastry KV,Sunita K

更新日期：1983-04-01 00:00:00

abstract：:The plastic chemical bisphenol A (BPA) has recently been suspected to be a base structure of endocrine disrupting chemicals, which achieve their adverse effects by interfering with human nuclear receptors. For instance, BPA, bisphenol AF, and tetrabromo- or tetrachloro-BPA (X₄-BPA) have been characterized as binders f...

journal_title：Toxicology letters

authors： Nishigori M,Nose T,Shimohigashi Y

更新日期：2012-07-20 00:00:00

abstract：INTRODUCTION:An increased health problem in industrialised countries is the contemporary concern of public and scientific community as well. This has been attributed in part to accumulated environmental pollutants especially radioactive substances and the use of nuclear power plants worldwide. However, the outcome of c...

journal_title：Toxicology letters

authors： Elmhiri G,Gloaguen C,Grison S,Kereselidze D,Elie C,Tack K,Benderitter M,Lestaevel P,Legendre A,Souidi M

更新日期：2018-01-05 00:00:00

abstract：:In this subacute toxicity study, ethyl methanesulfonate (EMS) was administered daily by oral gavage to SPF-bred Wistar rats of both sexes at dose levels of 20, 60 and 180/120 mg/kg body weight (bw)/day for a period of 28 days (for 19 days in the high-dose group). A control group was treated similarly with the vehicle,...

journal_title：Toxicology letters

authors： Pfister T,Eichinger-Chapelon A

更新日期：2009-11-12 00:00:00

abstract：:Harmonisation of risk assessment (RA) is one of the priorities for sound chemical management set by Chapter 19, Agenda 21 of the United Nations Conference on the Environment and Development (UNCED) 1992 Earth Summit. The benefits of harmonisation are self evident and include transportability and consistency of RA outc...

journal_title：Toxicology letters

authors： Di Marco PN,Priestly BG,Buckett KJ

更新日期：1998-12-28 00:00:00

abstract：:There are reports of fluorochloridone (FLC)-induced male reproductive toxicity, but the underlying toxicological mechanisms remain unknown. In this study, we looked at how FLC exposure affected the integrity of the blood-testis barrier (BTB) and the Sertoli cell barrier and studied the molecular mechanisms. Male rats ...

journal_title：Toxicology letters

authors： Liu L,Zhang Y,Chang X,Li R,Wu C,Tang L,Zhou Z

更新日期：2018-10-01 00:00:00

abstract：:Micronucleus (MN) induction by azidothymidine (AZT) in B and T lymphocytes was analyzed by a recently developed MAC (morphology-antibody-chromosome) method which allows the immunologic identification of different cell lineages. An increased frequency of MN in AZT-treated cultures compared with controls was observed. C...

journal_title：Toxicology letters

authors： Stern M,Cid MG,Larripa I,Slavutsky I

更新日期：1994-02-01 00:00:00

abstract：:A detailed characterisation of the biotransformation pathways followed by the chemical of interest is, evidently, of primordial importance to design reliable biomonitoring programs. This short overview discusses some recent studies that are of potential interest for the development of new avenues of research. Four top...

journal_title：Toxicology letters

authors： Lison D

更新日期：1999-09-05 00:00:00

abstract：:At the present work, different groups of rainbow trouts have been intraperitoneally treated with a polychlorinated biphenyls commercial mixture (Arochlor-1254) at three doses (5, 20 and 70 mg PCBs/ kg body weight) and they have been sampled at 0 (injection moment), 3, 6 and 9 weeks after xenobiotic exposure. Purificat...

journal_title：Toxicology letters

authors： Pérez-López M,Nóvoa-Valiñas MC,Melgar-Riol MJ

更新日期：2002-12-15 00:00:00

abstract：:Clinical study showed that smoking during pregnancy deceased the thymus size in newborns. However, the long-term effect remains unclear. This study was aimed to observe the effects of prenatal nicotine exposure (PNE) on the development of thymus and the T-lymphocyte subpopulation in mice offspring from the neonatal to...

journal_title：Toxicology letters

authors： Qu W,Zhao WH,Wen X,Yan HY,Liu HX,Hou LF,Ping J

更新日期：2019-04-01 00:00:00

abstract：:A single intravenous injection of 4-hydroxyaminoquinoline 1-oxide in a dose of 9 mg/kg induced exocrine adenomas of the pancreas in a significantly higher rate in male than in female rats. Castration following HAQO administration diminished the incidence of the pancreatic tumors in male rats. A combined treatment with...

journal_title：Toxicology letters

authors： Hayashi Y,Katayama H

更新日期：1981-12-01 00:00:00

abstract：:The early histologic lesions and sequential changes in the development of mirex-induced cataracts were studied in the offspring of lactating female Sherman rats given oral doses of mirex for 5 consecutive days post partum. The earliest histologic change, seen at neonatal day 7, was slight swelling of the individual co...

journal_title：Toxicology letters

authors： Scotti TM,Chernoff N,Linder R,McElroy WK

更新日期：1981-11-01 00:00:00

abstract：:Interactions of chemicals with cerebral neurotransmitters, receptors, and second messenger systems are often accompanied by similar changes involving components in non-neural tissues. On this basis, indirect strategies have been developed to investigate neural cell function parameters by methods using accessible cells...

journal_title：Toxicology letters

authors： Manzo L,Castoldi AF,Coccini T,Rossi AD,Nicotera P,Costa LG

更新日期：1995-05-01 00:00:00