Abstract:
:The people studied were male volunteers without occupational and dietary exposure to PAH: 27 smokers (10 cigarettes or more) and 27 non-smokers matched for age and socio-professional category. For each person, all the 24h voided urine samples were reassembled in a single sample. 1-Hydroxypyrene (1-OHPy) and 3-hydroxybenzo[a]pyrene (3-OHBaP) were then determined by automated column-switching high-performance liquid chromatography. Urinary 1-OHPy ranged from 0.041 to 0.530 micromol/molCreatinine (arithmetic mean 0.144, median 0.115) for smokers and from 0.01 to 0.148 mmol/molCreatinine (arithmetic mean 0.044, median 0.032) for non-smokers. These values are close to those of some other studies. Urinary 3-OHBaP ranged from <0.01 to 0.084 nmol/molCreatinine (arithmetic mean 0.030, median 0.023) for smokers and from <0.01 to 0.045 nmol/molCreatinine (arithmetic mean 0.014, median 0.011) for non-smokers. Considering more particularly the urinary 3-OHBaP values, the influence of smoking could be important among workers exposed to low levels of BaP (<100 ng/m(3)) and the concentrations for smokers were equivalent to most of the preshift values of exposed workers. The dietary BaP intake was slightly lower than the BaP intake for an average smoker. From the present study, temporary basic reference levels may be proposed for urinary 3-OHBaP.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Lafontaine M,Champmartin C,Simon P,Delsaut P,Funck-Brentano Cdoi
10.1016/j.toxlet.2005.09.019keywords:
subject
Has Abstractpub_date
2006-04-10 00:00:00pages
181-5issue
2-3eissn
0378-4274issn
1879-3169pii
S0378-4274(05)00296-1journal_volume
162pub_type
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journal_title:Toxicology letters
pub_type: 杂志文章,评审
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journal_title:Toxicology letters
pub_type: 杂志文章
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更新日期:2002-03-24 00:00:00