Abstract：
:The effects of 3 weeks' or 6 months' inhalation exposure of rats to aromatic white spirit 6 h/day, 5 days/week at 0, 400, or 800 ppm were studied. Synaptosomal neurochemistry was investigated as index of the in situ conditions in the presynaptic nerve terminal. In both studies, the relative and absolute yield of synaptosomal protein were significantly reduced in the two exposed groups. Both studies demonstrated increased synaptosomal noradrenaline (NA), dopamine (DA), and 5-hydroxytryptamine (5-HT) concentrations, high- affinity 5-HT uptake rate and uptake capacity. It is hypothesized that a reduced density and total number of synapses in situ may be functionally compensated by increased NA, DA, and 5-HT neurotransmitter release, or by increased activity of corresponding neurons. The increased synaptosomal 5-HT uptake rates and uptake capacities may explain the previously demonstrated increased global and regional neurotransmitter concentrations and the present finding of increased synaptosomal 5-HT concentrations. These changes are interpreted as an indication of toxic effect on the CNS function and are considered supportive of recent findings of electrophysiological changes and affected motor activity following 6 months' exposure to dearomatized white spirit followed by an exposure-free period.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Lam HR,Ostergaard G,Ladefoged Odoi
10.1016/0378-4274(95)03325-fsubject
Has Abstractpub_date
1995-10-01 00:00:00pages
39-48issue
1-3eissn
0378-4274issn
1879-3169pii
0378-4274(95)03325-Fjournal_volume
80pub_type
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更新日期：2018-03-01 00:00:00
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journal_title：Toxicology letters
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2007-02-28 00:00:00
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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更新日期：2012-09-03 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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更新日期：1983-03-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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更新日期：2002-03-10 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2014-08-17 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2011-07-28 00:00:00
