Chlordecone increased subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes without altering cytosolic cholesterol binding proteins.

abstract：:In order to gain basic understanding in the ecotoxicity of endocrine disrupting chemicals or EDCs (including natural chemicals and some pharmaceuticals), many international research groups are currently testing these chemicals using aquatic invertebrates. This paper discusses relevant examples to address key questions...

journal_title：Toxicology letters

authors： Hutchinson TH

更新日期：2002-05-10 00:00:00

abstract：:In this work the in vitro reactions of phosphine with intact red blood cells and membrane-free hemoglobin extracts are reported. We demonstrate that phosphine or phosphine derivatives induce dense aggregates of denatured hemoglobin known as 'Heinz bodies' in intact red blood cells. The reaction products include irreve...

journal_title：Toxicology letters

authors： Potter WT,Rong S,Griffith J,White J,Garry VF

更新日期：1991-06-01 00:00:00

abstract：:The grazing trial at Kidston Gold Mine, North Queensland, was aimed specifically to assess the uptake of metals from the tailing and the potential for unacceptable contamination of saleable meat. Further aims included estimating metal dose rates and identifying potential exposure pathways including plant uptake of hea...

journal_title：Toxicology letters

authors： Bruce SL,Noller BN,Grigg AH,Mullen BF,Mulligan DR,Ritchie PJ,Currey N,Ng JC

更新日期：2003-01-31 00:00:00

abstract：:In vitro effects of mercury-selenium compounds, as compared with mercurials, against glucose-6-phosphate dehydrogenase (G6PD), catalase and trypsin were studied. Inhibitory potencies of two mercury-selenium (Hg-Se) compounds, bis(methylmercuric) selenide (BMS), and a reaction product of HgCl2, Na2SeO3 and glutathione ...

journal_title：Toxicology letters

authors： Mochizuki Y,Kobayashi T,Doi R

更新日期：1982-12-01 00:00:00

abstract：:Nephrotoxicity limits the therapeutic efficacy of the antineoplastic drug cisplatin. Due to dosage adjustment and appropriate monitoring, most therapeutic courses with cisplatin produce no or minimal kidney damage. However, we studied whether even sub-nephrotoxic dosage of cisplatin poses a potential risk for the kidn...

journal_title：Toxicology letters

authors： Vicente-Vicente L,Sánchez-Juanes F,García-Sánchez O,Blanco-Gozalo V,Pescador M,Sevilla MA,González-Buitrago JM,López-Hernández FJ,López-Novoa JM,Morales AI

更新日期：2015-04-16 00:00:00

abstract：:Several incidences of reduction in the fertility (sperm count) have been reported in India and worldwide as well. Adulteration of food and consumption of adulterated mustard oil with argemone oil (AO) are presumed to be the factors for reduction in sperm count. In the present study we have studied the exfoliation of g...

journal_title：Toxicology letters

authors： Mishra V,Saxena DK,Das M

更新日期：2009-04-25 00:00:00

abstract：:Since guanidinoacetic acid (GAA), a precursor of creatine, is synthesized mainly in the proximal tubule of the kidney where gentamicin (GM) nephrotoxicity often occurs, GM-induced renal cell damage was investigated using GAA synthesis in tubular suspension as an indicator. Results obtained were as follows: (1) GAA syn...

journal_title：Toxicology letters

authors： Takeda M,Jung KY,Sekine T,Endou H,Koide H

更新日期：1995-11-15 00:00:00

abstract：:A multi-unit, dynamic flow, inhalation exposure system which is capable of accommodating 12 mice per unit has been described. Components of the system include a mixing board, one or more glass distributing tubes, and detachable glass chamber tubes. The flow of a specified concentration of test gas exits from the mixin...

journal_title：Toxicology letters

authors： Kapeghian JC,Waters IW,Jones AB

更新日期：1985-02-01 00:00:00

abstract：:The structural analogy of paraquat with 1-methyl-4-phenylpyridinium (MPP+) has been implied in the aetiology of Parkinson's disease. The cross-reactivity of MPP+ to a specific antibody to paraquat was assessed by radioimmunoassay and was found to be very low. The results suggest that this polyclonal paraquat antibody ...

journal_title：Toxicology letters

authors： Houzé P,Chappey O,Gallons H,Scherrmann JM

更新日期：1990-10-01 00:00:00

abstract：:Over the last twenty years research has provided an important insight into the mechanisms responsible for the immunotoxicity of both local and systemic adverse reactions following the use of immunostimulating drugs and adjuvants. In this article we provide an update of the present knowledge relating to the various par...

journal_title：Toxicology letters

authors： Batista-Duharte A,Lindblad EB,Oviedo-Orta E

更新日期：2011-06-10 00:00:00

abstract：:Apoptosis has been described as programmed active cell death. Overexpression of the c-Myc gene has been shown to induce apoptosis in Rat1A/Myc-ER cells when combined with a growth blocking agent. In the present study, we tested whether 4-Hydroxynonenal (HNE) or N-acetyl-L-cysteine (LNAC) affect apoptotic death in seru...

journal_title：Toxicology letters

authors： Yildiz D,Erçal N,Frank RL,Matthews RH

更新日期：1996-12-31 00:00:00

abstract：:Exposure to cyanide from gari, a popular cassava food in West Africa, is implicated in the causation of ataxic polyneuropathy and amblyopia, but this has been questioned because cyanide was not detected in gari in a study. This study was carried out to determine if gari is a source of exposure to cyanide. Gari (150 g)...

journal_title：Toxicology letters

authors： Oluwole OS,Onabolu AO,Sowunmi A

更新日期：2002-09-05 00:00:00

abstract：:The effects of sodium tellurite 0.1 and 0.4 mg/kg were assessed in the Morris water maze. Two days after treatment rats were tested for acquisition (posttreatment days 3-6) and on seventh day on a spatial retention task. Tellurium treatment was found to cause significant impairment in retention of the spatial learning...

journal_title：Toxicology letters

authors： Widy-Tyszkiewicz E,Piechal A,Gajkowska B,Smiałek M

更新日期：2002-05-28 00:00:00

abstract：:The alpha(2)-adrenoceptor antagonist yohimbine is known to interact with the effects of opioid receptor agonists in vivo, and thus could modulate the action of morphine-like analgesics. The focus of the present work was to further study these interactions in a cell culture endowed with opioid and alpha(2)-adrenoceptor...

journal_title：Toxicology letters

authors： Polanco MJ,Alguacil LF,Albella B,Segovia JC,González-Martín C

更新日期：2009-09-10 00:00:00

abstract：:Epidemiological studies have reported that humans have detectable levels of not only bisphenol A (BPA), but also its halogenated derivatives tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA), in the serum. Our previous study showed that BPA promotes ovarian cancer progression by directly inducing cell p...

journal_title：Toxicology letters

authors： Hoffmann M,Fiedor E,Ptak A

更新日期：2017-03-05 00:00:00

abstract：:Tetrachlorobenzyltoluene (TCBT) (Ugilec 141) was investigated in induction experiments in male and female Wistar rats with long-term (50, 100 and 300 mg/kg p.o. daily for 28 days) and short-term administration (300 mg/kg once and 100 mg/kg daily for 4 days). The increase in total cytochrome P-450 did not exceed the fa...

journal_title：Toxicology letters

authors： von Meyerinck L,Hufnagel B,Schmoldt A,Benthe HF

更新日期：1990-04-01 00:00:00

abstract：:Cyanobacteria ("blue-green algae"), such as Oscillatoria sp., are a ubiquitous group of bacteria found in freshwater systems worldwide that are linked to illness and in some cases, death among humans and animals. Exposure to cyanobacteria occurs via ingestion of contaminated water or food-products. Exposure of the gut...

journal_title：Toxicology letters

authors： Swanson-Mungerson M,Incrocci R,Subramaniam V,Williams P,Hall ML,Mayer AMS

更新日期：2017-06-05 00:00:00

abstract：:A major public health concern is the degree to which environmental or occupational exposures to exogenous chemicals result in adverse health effects. Biological markers have the potential for helping to answer this important question by providing links between markers of exposures and markers of early stages of the de...

journal_title：Toxicology letters

authors： Henderson RF

更新日期：1995-12-01 00:00:00

abstract：:The effect of sodium selenite administered acutely or repeatedly on the biochemical components of the hepatic microsomal monooxygenase enzyme system was examined in male rats. 72 h following acute administration of selenium (2.4 mg Se/kg, i.p.), there was a significant decrease in ethylmorphine-N-demethylase activity ...

journal_title：Toxicology letters

authors： Schnell RC,Early JL,Deimling MJ,Merrick BA,Davies MH

更新日期：1983-06-01 00:00:00

abstract：:Bisphenol A (BPA) is a potential endocrine disruptor. It has been shown that it can interfere with steroid biosynthesis and metabolism. However, the mechanism is unclear. The objective of the present study is to investigate the effects of BPA on two isoforms of 11β-hydroxysteroid dehydrogenases (11β-HSD1 and 11β-HSD2)...

journal_title：Toxicology letters

authors： Guo J,Yuan X,Qiu L,Zhu W,Wang C,Hu G,Chu Y,Ye L,Xu Y,Ge RS

更新日期：2012-11-30 00:00:00

abstract：:The phthalates di(2-ethylhexyl)phthalate (DEHP) and di-n-butyl phthalate (DBP) are environmental contaminants with significant human exposures. Both compounds are known reproductive toxins in rodents and DEHP also induces rodent hepatocarcinogenesis in a process believed to be mediated via the peroxisome proliferator-...

journal_title：Toxicology letters

authors： Venkata NG,Robinson JA,Cabot PJ,Davis B,Monteith GR,Roberts-Thomson SJ

更新日期：2006-06-01 00:00:00

abstract：:Acetylcholinesterase (AChE)-induced chewing movements, tremors, convulsions and hind limb abduction at doses of 50-85% LD50 in rats were monitored in order to determine whether the severity of these different signs would correlate with brain AChE levels and the time course of such a relationship. 30 min after subcutan...

journal_title：Toxicology letters

authors： Hoskins B,Fernando JC,Dulaney MD,Lim DK,Liu DD,Watanabe HK,Ho IK

更新日期：1986-02-01 00:00:00

abstract：:Male Swiss Webster mice were given an intravenous dose of 50 mg/kg, or an oral gavage dose of 5, 50 or 500 mg/kg [1, 2-(14)C]-ethylenediamine dihydrochloride, and its fate was followed for 48 h. Ethylenediamine (EDA) was readily absorbed from the gut (bioavailability, 87% measured at 50 mg/kg). Absorption was rapid as...

journal_title：Toxicology letters

authors： Leung HW

更新日期：2000-09-30 00:00:00

abstract：:3-methyladenine DNA glycosylase (AlkD) belongs to a new family of DNA glycosylases; it initiates repair of cytotoxic and promutagenic alkylated bases (its main substrates being 3-methyladenine and 7-methylguanine). The modification of the comet assay (single cell gel electrophoresis) using AlkD enzyme thus allows asse...

journal_title：Toxicology letters

authors： Hašplová K,Hudecová A,Magdolénová Z,Bjøras M,Gálová E,Miadoková E,Dušinská M

更新日期：2012-01-05 00:00:00

abstract：:The activity of femoral-epiphyseal acid phosphatase, a marker enzyme of bone resorption induced by parathyroid hormone, was increased by a single oral dose of Zn 100 mg/kg to rats. This increase was completely inhibited by calcitonin which has antagonistic effect on the action of parathyroid hormone on bone, thus supp...

journal_title：Toxicology letters

authors： Yamaguchi M,Takahashi K

更新日期：1983-10-01 00:00:00

abstract：:Even though compounds of nickel, arsenic, cobalt and cadmium are carcinogenic, their mutagenic potentials are rather weak. In contrast, they exert pronounced comutagenic effects, which may be explained by disturbances of different DNA repair systems. Thus, cobalt, arsenic, nickel and cadmium interfere with base and nu...

journal_title：Toxicology letters

authors： Hartwig A,Schwerdtle T

更新日期：2002-02-28 00:00:00

abstract：:A lack of well-established parameters and assessment values currently impairs biomonitoring of n-heptane exposure. Using controlled inhalation experiments, we collected information on urinary n-heptane metabolite concentrations and the time course of metabolite excretion. Relationships between external and internal ex...

journal_title：Toxicology letters

authors： Rossbach B,Kegel P,Letzel S

更新日期：2018-12-01 00:00:00

abstract：:Phosgene Oxime (CX, Cl2CNOH), a halogenated oxime, is a potent chemical weapon that causes immediate acute injury and systemic effects. CX, grouped together with vesicating agents, is an urticant or nettle agent with highly volatile, reactive, corrosive, and irritating vapor, and has considerably different chemical pr...

journal_title：Toxicology letters

authors： Goswami DG,Agarwal R,Tewari-Singh N

更新日期：2018-09-01 00:00:00

abstract：:In this paper, the difficulties of genetic screening of occupationally exposed subjects for the evaluation of retrospective, and prospective, health risk assessments is illustrated with reference to glutathione S-transferase (GST) function. Individual differences in the magnitude and half-life of adduct levels, derive...

journal_title：Toxicology letters

authors： Leng G,Lewalter J

更新日期：2002-08-05 00:00:00

abstract：:Since a number of food and food products contain 2,4-hexadienal (HX), an unsaturated aldehyde, human exposure to HX is likely. Long term HX feeding to rodents induces forestomach cancers. Aldehyde dehydrogenases (ALDH) are key enzymes in the stomach for the metabolism of aldehydes. We examined the effect of short term...

journal_title：Toxicology letters

authors： Lee PC,Picchiottino C

更新日期：2003-01-13 00:00:00