Abstract：
:Male Swiss Webster mice were given an intravenous dose of 50 mg/kg, or an oral gavage dose of 5, 50 or 500 mg/kg [1, 2-(14)C]-ethylenediamine dihydrochloride, and its fate was followed for 48 h. Ethylenediamine (EDA) was readily absorbed from the gut (bioavailability, 87% measured at 50 mg/kg). Absorption was rapid as the EDA concentration in plasma reached a maximum at about 1 h after dosing. 14C-EDA-derived radioactivity was distributed throughout the body, with the liver and kidney attaining the highest concentration among the major organs. Urine was the major route of excretion, accounting for over half of the dose. About 4-13 and 8% of the dose was eliminated in the feces and as expired CO(2), respectively. Excretion was quite rapid, with over 70% of the applied dose eliminated within 24 h. The principal metabolite in the urine was N-acetylethylenediamine. There was some indication that the metabolism of EDA in the mouse might be saturated at 500 mg/kg, as the percentage of N-acetylethylenediamine excreted in the urine decreased markedly, with a concomitant shift to a higher proportion of unchanged EDA, when compared with the lower dosages.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Leung HWdoi
10.1016/s0378-4274(00)00252-6keywords:
subject
Has Abstractpub_date
2000-09-30 00:00:00pages
107-14issue
1-2eissn
0378-4274issn
1879-3169pii
S0378-4274(00)00252-6journal_volume
117pub_type
杂志文章abstract：:Neoangiogenesis and the development of an abnormal angio-architecture in the liver are strongly linked with progressive fibrogenesis. This study aimed to evaluate the ability of curcumin to protect liver fibrosis-associated angiogenesis and capillarization of the sinusoids in experimental rats. Liver fibrosis was indu...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2013.06.240
更新日期：2013-09-12 00:00:00
abstract：:A major issue of inhalation toxicity is that of dose. An inhaled dose is more difficult to determine than the dose from other routes of administration. Via oral or parenteral routes, a discrete amount of test substance is given in a bolus. In inhalation toxicology, the delivered dose depends on the exposure concentrat...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/s0378-4274(03)00077-8
更新日期：2003-04-11 00:00:00
abstract：:Male mice (Q strain) received a single i.p. injection of 14 organophosphorus compounds, including 11 insecticides, administered on separate occasions. After a recovery period of 10 to 15 days, the cytogenic effects were analyzed in primary spermatocytes at diakinesis-metaphase I corresponding to the treatment of A4-B ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(84)90090-0
更新日期：1984-06-01 00:00:00
abstract：:Benzidine dihydrochloride administered in water at 0, 30, 60, 120, 200 or 400 ppm to 1664 mice induced a total of 368 hepatocellular carcinomas, of which 34 or 9.2% metastasized to the lungs. Liver tumors which were larger and heavier were more prone to metastasize and all that metastasized contained areas of prominen...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(80)90042-9
更新日期：1980-12-01 00:00:00
abstract：:Fenitrothion (FNT) is used worldwide in agricultural and public health settings. Spermatogenesis is a toxicological target of FNT under high-dose exposure. Although anti-androgenic action is postulated to be the mechanism associated with this toxicity, few studies have examined histopathology of androgen-dependent mal...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2017.12.023
更新日期：2018-03-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(84)90129-2
更新日期：1984-11-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2019.12.014
更新日期：2020-03-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(84)90037-7
更新日期：1984-07-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2012-02-25 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(97)00071-4
更新日期：1997-09-19 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(01)00323-x
更新日期：2001-10-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2010.05.007
更新日期：2010-09-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2009-07-24 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2020-02-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(00)00217-4
更新日期：2000-07-27 00:00:00
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更新日期：2009-12-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(94)03180-0
更新日期：1995-02-01 00:00:00
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journal_title：Toxicology letters
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更新日期：2012-11-23 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2009.01.022
更新日期：2009-05-22 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1994-02-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(99)00176-9
更新日期：1999-12-20 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2010.01.004
更新日期：2010-03-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2004-04-01 00:00:00
abstract：:Haemolysis by chrysotile fibres may be related to an adsorption of the red blood cell (RBC) membranes on the fibres and not to an interaction between magnesium (Mg) from the fibres and sialic acid from RBC. This was demonstrated using neuraminidase (NANASE)-treated RBC and Mg-depleted chrysotile fibres. The mechanism ...
journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：1983-02-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(98)00085-x
更新日期：1998-08-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2011.02.011
更新日期：2011-05-10 00:00:00
abstract：:In order to elucidate the mechanisms by which long-term treatment with clobazam (CLB), 1,5-benzodiazepine, induces thyroid follicular cell tumors in male rats, male Sprague-Dawley (SD) rats were treated orally with 400 mg/kg of CLB for up to 4 weeks, and the contribution of feedback through elevated thyroid stimulatin...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2003.08.002
更新日期：2003-12-10 00:00:00
abstract：:Because coarse mode particles are rarely studied in their existing size ranges (greatest mass about 5-7 microns, aerodynamic diameter), we investigated the effects of four such particles, quartz, ferric oxide, calcium carbonate, and sodium feldspar, on host defenses against bacterial pulmonary infection. Mice which re...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(83)90263-1
更新日期：1983-10-01 00:00:00
