Potential mechanisms of tumorigenic action of diethanolamine in mice.

Abstract:

:Diethanolamine (DEA), a secondary amine found in a number of consumer products, reportedly induces liver tumors in mice. In an attempt to define the tumorigenic mechanism of DEA, N-nitrosodiethanolamine (NDELA) formation in vivo and development of choline deficiency were examined in mice. DEA was administered with or without supplemental sodium nitrite to B6C3F1 mice via dermal application (with or without access to the application site) or via oral gavage for 2 weeks. Blood levels of DEA reflected the dosing method used; oral greater than dermal with access greater than dermal without access. No NDELA was observed in the urine, blood or gastric contents of any group of treated mice. Choline, phosphocholine and glycerophosphocholine were decreased

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Stott WT,Bartels MJ,Brzak KA,Mar M,Markham DA,Thornton CM,Zeisel SH

doi

10.1016/s0378-4274(99)00197-6

keywords:

subject

Has Abstract

pub_date

2000-04-03 00:00:00

pages

67-75

issue

1-3

eissn

0378-4274

issn

1879-3169

pii

S0378427499001976

journal_volume

114

pub_type

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