Urban fine particulate matter exposure causes male reproductive injury through destroying blood-testis barrier (BTB) integrity.

abstract：:General anaesthesia is an important measure in the treatment of patients suffering from organophosphorus intoxication. The intravenous anaesthetic etomidate seems to be well suited for this purpose because of its stable haemodynamics. Here we raise the question whether the anaesthetic properties of etomidate are alter...

journal_title：Toxicology letters

authors： Drexler B,Antkowiak B,Thiermann H,Seeger T,Grasshoff C

更新日期：2010-10-20 00:00:00

abstract：:Fatty acid composition was studied in milk at day 14 and in liver at day 24 after parturition of lactating rats exposed to 0 ppm, 5 ppm or 25 ppm cadmium (Cd) via drinking water for 17 days during lactation, and in the brain of their offspring at day 19 after birth. In the liver phospholipid fraction, 22:5(n-3) was si...

journal_title：Toxicology letters

authors： Grawé KP,Pickova J,Dutta PC,Oskarsson A

更新日期：2004-03-14 00:00:00

abstract：:A short-term initiation/promotion bioassay has been developed in rat liver using putative preneoplastic foci as the endpoint for the detection of chemical carcinogens. The two protocols of the bioassay used in this study were varied according to the time 2/3 partial hepatectomy was performed in relation to when the in...

journal_title：Toxicology letters

authors： Herren SL,Pereira MA,Britt AL,Khoury MK

更新日期：1982-07-01 00:00:00

abstract：:Toxicity of an aqueous extract prepared from Echinodorus macrophyllus dried leaves, a plant used in folk medicine to treat inflammation and kidney malfunctions, was estimated by different bioassays. Mutagenicity of the aqueous extract was evaluated in the Salmonella/microsome assay (TA97a, TA98, TA100 and TA102 strain...

journal_title：Toxicology letters

authors： da Costa Lopes L,Albano F,Augusto Travassos Laranja G,Marques Alves L,Fernando Martins e Silva L,Poubel de Souza G,de Magalhães Araujo I,Firmino Nogueira-Neto J,Felzenszwalb I,Kovary K

更新日期：2000-08-16 00:00:00

abstract：:Styrene oxide, a metabolite of styrene, reacts with many centres in nucleosides but in DNA N-7-, N2- and O6-guanine are the main sites. A 32P-postlabelling method was developed for the detection of O6-styrene oxide DNA adducts from white blood cells. The method involved use of nuclease P1 and magnet transfer. The O6 a...

journal_title：Toxicology letters

authors： Hemminki K,Vodicka P

更新日期：1995-05-01 00:00:00

abstract：:Syrian golden hamsters are much more susceptible than Wistar rats to the induction of tracheal tumors by benzo(a)pyrene (BP). In order to investigate whether this difference is reflected in the pattern of DNA-adduct induction and removal, tracheas from either species were isolated and exposed to BP (5 micrograms/ml) i...

journal_title：Toxicology letters

authors： Roggeband R,Wolterbeek AP,van den Berg PT,Baan RA

更新日期：1994-06-01 00:00:00

abstract：:Mercury(II) ions are known to accumulate in the kidney and their effect upon the renin-angiotensin system has also been described. The question, however, whether mercury(II) also exerts direct effect on the juxtaglomerular cells (JGC) to induce renin release remained to be answered. Suspension of isolated glomeruli wa...

journal_title：Toxicology letters

authors： Kozma L,Lenkey A,Varga E,Gomba S

更新日期：1996-04-01 00:00:00

abstract：:Rats surviving various single dose of the organophosphorus anticholinesterase nerve agents Soman and Sarin were examined by light microscopy at intervals up to 35 days post-exposure. Brain lesions, identical to those that have been reported elsewhere were present, as well as a previously unreported finding associated ...

journal_title：Toxicology letters

authors： Singer AW,Jaax NK,Graham JS,McLeod CG Jr

更新日期：1987-05-01 00:00:00

abstract：:Antioxidants of the vitamin E family have protective effects against metal toxicity. We examined the protective effect of racemic LLU-alpha [2,7,8-trimethyl-2-(carboxyethyl)-6-hydroxychroman] a metabolite of gamma-tocopherol, in comparison to the effect of alpha- and gamma-tocopherol in rats treated with sodium dichro...

journal_title：Toxicology letters

authors： Appenroth D,Karge E,Kiessling G,Wechter WJ,Winnefeld K,Fleck C

更新日期：2001-07-06 00:00:00

abstract：:Clinical study showed that smoking during pregnancy deceased the thymus size in newborns. However, the long-term effect remains unclear. This study was aimed to observe the effects of prenatal nicotine exposure (PNE) on the development of thymus and the T-lymphocyte subpopulation in mice offspring from the neonatal to...

journal_title：Toxicology letters

authors： Qu W,Zhao WH,Wen X,Yan HY,Liu HX,Hou LF,Ping J

更新日期：2019-04-01 00:00:00

abstract：:Aminoglycosides have detrimental effects on the hair cells of the inner ear, yet these agents indisputably are one of the cornerstones in antibiotic therapy. Hence, there is a demand for strategies to prevent aminoglycoside-induced ototoxicity, which are not available today. In vitro data suggests that the pleiotropic...

journal_title：Toxicology letters

authors： Bächinger D,Horvath L,Eckhard A,Goosmann MM,Honegger T,Gassmann M,Vogel J,Naldi AM

更新日期：2018-07-01 00:00:00

abstract：:EDTA, 1,2-cyclohexylenediamine tetra-acetic acid (CDTA), hexamethylene 1,6-diamine N,N,N',N'-tetra-acetic acid (HDTA), diethylene-triamine pentaacetic acid (DTPA) and nitrilotriacetic acid (NTA) were examined for the removal of manganese-54(54Mn) from some organs of sham-operated and partially hepatectomized rats in e...

journal_title：Toxicology letters

authors： Kaur G,Srivastava UC,Dwivedi RS,Srivastava RC

更新日期：1984-07-01 00:00:00

abstract：:Many industrially and environmentally important industrial carcinogens display effects that lead them to be viewed and regulated as 'genotoxic compounds'. Some of these chemicals cause experimental tumours only at high or toxic doses. The current view is that non-threshold principles should be applied for risk assessm...

journal_title：Toxicology letters

authors： Bolt HM

更新日期：2003-04-11 00:00:00

abstract：:Kahweol, the coffee-specific diterpene, has been reported to have anti-carcinogenic properties. Animal data support such a chemopreventive effect of coffee. However, the precise underlying protective mechanisms are poorly understood. In this study, the apoptotic effect of kahweol in human lung adenocarcinoma A549 cell...

journal_title：Toxicology letters

authors： Kim HG,Hwang YP,Jeong HG

更新日期：2009-05-22 00:00:00

abstract：:Polybrominated diphenyl ethers (PBDEs) are widespread environmental pollutants, and the levels of certain congeners have been increasing in biota and abiota in recent decades. Some PBDEs are lipophilic and persistent, resulting in bioaccumulation in the environment. Their structural similarity to other polyhalogenated...

journal_title：Toxicology letters

authors： Peters AK,Sanderson JT,Bergman A,van den Berg M

更新日期：2006-07-01 00:00:00

abstract：:On chronic administration of 20 microliter of chilli extract to the cheek pouch of hamsters till death, 23% of the hamsters developed shrunken eye balls and closing of the eyelids. This effect was not observed in hamsters which received a single application of the potent carcinogen methylacetoxymethyl nitrosamine (DMN...

journal_title：Toxicology letters

authors： Agrawal RC,Sarode AV,Lalitha VS,Bhide SV

更新日期：1985-10-01 00:00:00

abstract：:Accumulation of macrophages and neutrophil granulocytes in the lung are key events in the inflammatory response to inhaled particles. The present study aims at the time course of chemotaxis in vitro in response to the challenge of various biopersistent particles and its functional relation to the transcription of infl...

journal_title：Toxicology letters

authors： Schremmer I,Brik A,Weber DG,Rosenkranz N,Rostek A,Loza K,Brüning T,Johnen G,Epple M,Bünger J,Westphal GA

更新日期：2016-11-30 00:00:00

abstract：:The effects of menadione on activities and expression of cytochrome P450 (CYP) 1A subfamily (CYP1A) isozymes in rat hepatic tissue were examined. When rats were treated orally with 15 mg/kg menadione for 4 days, the elevation of hepatic CYP1A1/1A2 specific activities in microsomal preparations was detected with approx...

journal_title：Toxicology letters

authors： Sidorova YA,Grishanova AY,Lyakhovich VV

更新日期：2005-02-15 00:00:00

abstract：:The objective of the present study was to identify the polychlorinated biphenyl congeners of Aroclor 1254 that are responsible for the induction of the cytosolic bioactivation of aromatic amines. Various chlorobiphenyls, ranging from di- to hexa-substituted, were administered to rats and the ability of the hepatic cyt...

journal_title：Toxicology letters

authors： Marczylo T,Ioannides C

更新日期：1997-07-21 00:00:00

abstract：:Quality control studies on cotinine measurements following low level environmental tobacco smoke (ETS) exposure are rare. The exposure to ETS was controlled and systematically changed in a series of experiments in a climatic chamber. Healthy nonsmoking volunteers were exposed to ETS simultaneously. The duration and le...

journal_title：Toxicology letters

authors： Letzel H,Fischer-Brandies A,Johnson LC,Uberla K,Biber A

更新日期：1987-01-01 00:00:00

abstract：:We previously reported that NR2E3, an orphan nuclear receptor, plays an important role in maintaining the basal expression of estrogen receptor α (ER) and that the NR2E3 level is highly correlated with the relapse-free survival of breast cancer patients. Here, we investigated the role of NR2E3 in benzo(a)pyrene (BaP)-...

journal_title：Toxicology letters

authors： Khanal T,Kim D,Johnson A,Choubey D,Kim K

更新日期：2015-09-17 00:00:00

abstract：:This study attempted the liposomalization of coproporphyrin I (CPI) with hydrophobic properties. Liposomalization of CPI was not successful at any pH when using lactate buffer. In contrast, when using 9% sucrose/10mM phosphate buffer (pH 7.8), CPI liposomes (Lipo-CPI) and polyethyleneglycol (PEG) modified liposomes (P...

journal_title：Toxicology letters

authors： Sadzuka Y,Iwasaki F,Sugiyama I,Horiuchi K,Hirano T,Ozawa H,Kanayama N,Oku N

更新日期：2008-11-10 00:00:00

abstract：:Since a number of food and food products contain 2,4-hexadienal (HX), an unsaturated aldehyde, human exposure to HX is likely. Long term HX feeding to rodents induces forestomach cancers. Aldehyde dehydrogenases (ALDH) are key enzymes in the stomach for the metabolism of aldehydes. We examined the effect of short term...

journal_title：Toxicology letters

authors： Lee PC,Picchiottino C

更新日期：2003-01-13 00:00:00

abstract：:A major public health concern is the degree to which environmental or occupational exposures to exogenous chemicals result in adverse health effects. Biological markers have the potential for helping to answer this important question by providing links between markers of exposures and markers of early stages of the de...

journal_title：Toxicology letters

authors： Henderson RF

更新日期：1995-12-01 00:00:00

abstract：:Dioxins are metabolized by cytochrome P450, family 1 (CYP1) via the aromatic hydrocarbon receptor (AHR). We determined whether different blood dioxin concentrations are associated with polymorphisms in AHR (dbSNP ID: rs2066853), AHR repressor (AHRR; rs2292596), CYP1 subfamily A polypeptide 1 (CYP1A1; rs4646903 and rs1...

journal_title：Toxicology letters

authors： Kobayashi S,Sata F,Sasaki S,Ban S,Miyashita C,Okada E,Limpar M,Yoshioka E,Kajiwara J,Todaka T,Saijo Y,Kishi R

更新日期：2013-06-07 00:00:00

abstract：:Anthocyanins are plant pigments occurring in flowers and berry fruits. Since a phenomenon of food-drug interactions is increasingly emerging, we examined the effects of 21 major anthocyanins and the extracts from 3 food supplements containing anthocyanins on the aryl hydrocarbon receptor (AhR)-cytochrome P450 CYP1A1 s...

journal_title：Toxicology letters

authors： Kamenickova A,Anzenbacherova E,Pavek P,Soshilov AA,Denison MS,Zapletalova M,Anzenbacher P,Dvorak Z

更新日期：2013-07-31 00:00:00

abstract：:There is potential for oral exposure of humans to styrene (ST) such as from migration of residual levels in polystyrene food containers. After absorption, ST is metabolised to styrene-7,8-oxide (SO), an alkylating epoxide. Hence, a comparison of blood burdens of SO resulting from oral exposures to ST was made with SO ...

journal_title：Toxicology letters

authors： Filser JG,Gelbke HP

更新日期：2016-04-15 00:00:00

abstract：:The handling of elemental gallium is not thought to be harmful, but this assumption does not consider metal coordination which readily occurs in physiological fluids. The aim of this work was to determine Ga(III) coordination behaviour in simple solutions and assess the effects of complex formation upon skin permeatio...

journal_title：Toxicology letters

authors： Staff K,Brown MB,Chilcott RP,Hider RC,Jones SA,Kong XL

更新日期：2011-05-10 00:00:00

abstract：:To determine whether occupational exposure to trichloroethylene (TCE) influences sympathetic nerve activity, serum dopamine-beta-hydroxylase (DBH) activities were analyzed in 84 male workers exposed to TCE and 83 male age-matched controls. The workers were exposed to about 22 ppm TCE in air. There were no significant ...

journal_title：Toxicology letters

authors： Nagaya T,Ishikawa N,Hata H

更新日期：1990-12-01 00:00:00

abstract：:Several in vivo and in vitro studies have assessed methods of evaluating the cardio toxicity of compounds during drug development due to its importance for predicting human toxicity. However, in vivo/in vitro relationships have not yet been reported using a zebrafish model. This study determined the bradycardia of 15 ...

journal_title：Toxicology letters

authors： Park MJ,Lee KR,Shin DS,Chun HS,Kim CH,Ahn SH,Bae MA

更新日期：2013-01-10 00:00:00