Melamine, beyond the kidney: A ubiquitous endocrine disruptor and neurotoxicant?

Abstract:

:Melamine is commonly used in a variety of consumer products such as furniture, dining ware, and food utensils. The chemical infamously gained worldwide attention by its illegal addition to a variety of foodstuffs in order to falsify protein content, which led to serious, sometimes fatal, health impacts in children and pets. This resulted in a large amount of published primary studies and reviews of the impacts of melamine exposure on kidney function. However, a growing body of literature suggests that melamine may have impacts beyond renal dysfunction. We conducted a scoping review of this literature which yielded more than 40 studies with human, animal, and in vitro findings. Neurological impacts, reproductive function, and anthropometric outcomes were identified as possible candidates for systematic review based on evidence stream and replication of endpoints. The results of this analysis provide a basis for prioritizing future research on health impacts associated with melamine exposure.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Bolden AL,Rochester JR,Kwiatkowski CF

doi

10.1016/j.toxlet.2017.07.893

subject

Has Abstract

pub_date

2017-10-05 00:00:00

pages

181-189

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(17)31139-6

journal_volume

280

pub_type

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