Abstract：
:The repeated use of the nerve agent sarin against civilians in Syria in 2013 emphasizes the continuing threat by chemical warfare agents. Multiple studies demonstrated a limited efficacy of standard atropine-oxime treatment in nerve agent poisoning and called for the development of alternative and more effective treatment strategies. A novel approach is the use of stoichiometric or catalytic bioscavengers for detoxification of nerve agents in the systemic circulation prior to distribution into target tissues. Recent progress in the design of enzyme mutants with reversed stereo selectivity resulting in improved catalytic activity and their use in in vivo studies supports the concept of catalytic bioscavengers. Yet, further research is necessary to improve the catalytic activity, substrate spectrum and in vivo biological stability of enzyme mutants. The pros and cons of catalytic bioscavengers will be discussed in detail and future requirements for the development of catalytic bioscavengers will be proposed.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Worek F,Thiermann H,Wille Tdoi
10.1016/j.toxlet.2015.07.012subject
Has Abstractpub_date
2016-02-26 00:00:00pages
143-148eissn
0378-4274issn
1879-3169pii
S0378-4274(15)30016-3journal_volume
244pub_type
杂志文章,评审abstract：:Nickel (Ni) can disorder testosterone synthesis in rat Leydig cells, whereas the mechanisms remain unclear. The aim of this study was to investigate the role of reactive oxygen species (ROS) and mitogen-activated protein kinases (MAPKs) in Ni-induced disturbance of testosterone synthesis in rat Leydig cells. The testo...
journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2018-06-15 00:00:00
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journal_title：Toxicology letters
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pub_type： 杂志文章
doi：10.1016/0378-4274(94)90061-2
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2005.03.002
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(85)90163-8
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
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journal_title：Toxicology letters
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journal_title：Toxicology letters
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更新日期：2019-04-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(83)90057-7
更新日期：1983-06-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2011.12.018
更新日期：2012-03-25 00:00:00
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pub_type： 杂志文章
doi：10.1016/0378-4274(96)03767-8
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2008.11.013
更新日期：2009-02-25 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(01)00465-9
更新日期：2002-03-24 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(84)90203-0
更新日期：1984-05-01 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2012-11-23 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2011.07.009
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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journal_title：Toxicology letters
pub_type： 杂志文章,评审
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abstract：:Asthma is a common chronic inflammatory disease which severely reduces the quality of life in patients. Studies have demonstrated that both PM2.5 and cold stress contribute to the development of asthma. However, the combined effects of these two risking factors are unknown. In this study, we investigated the combined ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2019.09.011
更新日期：2019-11-01 00:00:00
abstract：:Dioxins are a class of extremely toxic environmentally persistent pollutant, comprised of halogenated dibenzo-p-dioxins, dibenzofurans and biphenyls. Despite significant human exposure via multiple routes, very little is known about toxicity induced by dibenzofuran (DF). Current study shed lights on the potential toxi...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2012.08.014
更新日期：2012-10-17 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2019.09.015
更新日期：2019-12-15 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
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更新日期：2003-11-30 00:00:00
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journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2011.10.013
更新日期：2012-01-05 00:00:00
abstract：:Localization of specific mRNA and protein molecules within cells and tissues can provide important information on the effects of a drug within a biological test system and help elucidate mechanisms of drug-induced toxicity and organ dysfunction. The most widely used techniques for measuring the cellular and tissue dis...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/s0378-4274(99)00204-0
更新日期：2000-03-15 00:00:00
