Abstract：
:Acrylonitrile (ACN) is a widely used intermediate in the manufacture of plastics, acrylic fibers, synthetic rubbers and resins that are used in a variety of products including food containers and medical devices. ACN is a possible human carcinogen and a documented animal carcinogen, with the stomach being an important target of its toxicity. ACN has been previously reported to require metabolic activation to reactive intermediates and finally to cyanide (CN⁻). The current study aimed at exploring the potential role of neutrophils in ACN-induced gastric damage in rats. Experimental neutropenia was attained by injecting rats with methotrexate. This significantly ameliorated gastric mucosal injury induced by ACN. This is evidenced by protection against the increase in gastric ulcer index, myeloperoxidase (MPO) activity and CN⁻ level. Also, neutropenia guarded against the decrease in prostaglandin E2 (PGE2), induction of oxidative stress and reduction of total nitrites and alleviated histopathological alterations in rat stomachs. These data indicate that neutrophil infiltration is, at least partly, involved in ACN-induced gastric damage in rats.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Hamdy NM,Al-Abbasi FA,Alghamdi HA,Tolba MF,Esmat A,Abdel-Naim ABdoi
10.1016/j.toxlet.2011.10.018subject
Has Abstractpub_date
2012-01-25 00:00:00pages
108-14issue
2eissn
0378-4274issn
1879-3169pii
S0378-4274(11)01593-1journal_volume
208pub_type
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